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- 1From: Nature Reviews Molecular Cell Biology. (Vol. 8, Issue 12) Peer-ReviewedWhile the number of sequenced genomes continues to grow, experimentally verified functional annotation of whole genomes remains patchy. Structural genomics projects are yielding many protein structures that have unknown...
- 2From: Nature Reviews Molecular Cell Biology. (Vol. 8, Issue 12) Peer-ReviewedWhile studying the developmental role of E-NTPDase2, which metabolizes ATP to produce the purine ADP, Mass6 et al. unexpectedly induced ectopic eye production in Xenopus laevis. Further examination revealed that a new...
- 3From: Nature Reviews Molecular Cell Biology. (Vol. 8, Issue 12) Peer-Reviewed* http://fly-fish.ccbr.utoronto.ca Contrary to expectations, many Drosophila melanogaster mRNA transcripts appear to be localized prior to translation, report Henry Krause and colleagues in Cell. Localization of mRNA...
- 4From: Nature Reviews Molecular Cell Biology. (Vol. 8, Issue 12) Peer-ReviewedCells somehow evolved from primordial chemistry and their emergence depended on the co-evolution of the cytoplasm, a genetic system and the cell membrane. It is widely believed that the cytoplasm evolved inside a...
- 5From: Nature Reviews Molecular Cell Biology. (Vol. 8, Issue 12) Peer-ReviewedDNA double-strand breaks (DSBs) that occur in the S and G2 phases of the cell cycle are mainly repaired by homologous recombination (HR). HR is initiated by resection of the DNA strands surrounding a DSB, resulting in...
- 6From: Nature Reviews Molecular Cell Biology. (Vol. 8, Issue 12) Peer-ReviewedLigands of the transforming growth factor-β (TGFβ) superfamily of growth factors initiate signal transduction through a bewildering complexity of ligand-receptor interactions. Signalling then converges to nuclear...
- 7From: Nature Reviews Molecular Cell Biology. (Vol. 8, Issue 12) Peer-ReviewedA decade has passed since SUMO (small ubiquitin-related modifier) was discovered to be a reversible post-translational protein modifier. During this time many enzymes that participate in regulated SUMO-conjugation and...
- 8From: Nature Reviews Molecular Cell Biology. (Vol. 8, Issue 12) Peer-ReviewedResearchers have answered a longstanding question in developmental biology by revealing the driving forces of the massive cell movements that occur during early embryonic development. Gastrulation is a crucial stage in...
- 9From: Nature Reviews Molecular Cell Biology. (Vol. 8, Issue 12) Peer-ReviewedBostrom, P. et al Nature Cell Biol 9, 1286-1293 (2007) Lipid droplets are dynamic intracellular stores for neutral lipids. A team led by Sven-Olof Olofsson now shows that cytosolic lipid droplets are associated with...
- 10From: Nature Reviews Molecular Cell Biology. (Vol. 8, Issue 12) Peer-ReviewedRab proteins are members of the Ras GTPase superfamily and are known regulators of membrane-trafficking events. There is an increasing body of evidence that links Rab-regulated recycling pathways to cell polarization,...
- 11From: Nature Reviews Molecular Cell Biology. (Vol. 8, Issue 12) Peer-ReviewedLivet, J. et ol Nature 450, 56-62 (2007) Livet and colleagues describe a new method for visualizing neuronal circuits by genetically labelling neurons with a range of different colours. This methodology, which could be...
- 12From: Nature Reviews Molecular Cell Biology. (Vol. 8, Issue 12) Peer-ReviewedThe promyelocytic leukaemia (PML) tumour suppressor protein epitomizes the PML-nuclear body (PML-N B) and is crucially required for the proper assembly of this macromolecular nuclear structure. Unlike other, more...
- 13From: Nature Reviews Molecular Cell Biology. (Vol. 8, Issue 12) Peer-ReviewedVarious chemical modifications on histones and regions of associated DNA play crucial roles in genome management by binding specific factors that, in turn, serve to alter the structural properties of chromatin. These...
- 14From: Nature Reviews Molecular Cell Biology. (Vol. 8, Issue 12) Peer-ReviewedYin, H. N Lin, H. Nature 21 Oct 2007 (doi:10.1038/nature06263] Drosophila melanogaster Piwi (P-element induced wimpy testis) is a conserved regulatory protein that, together with repeat-associated small-interfering...
- 15From: Nature Reviews Molecular Cell Biology. (Vol. 8, Issue 12) Peer-ReviewedSharma, C.M. etol Genes Dev 21, 2804-2817 (2007) Enterobacterial small non-coding RNAs (sRNAs) function as stoess-response and virulence gene regulators. Many repress translation by masking the ribosome binding site...
- 16From: Nature Reviews Molecular Cell Biology. (Vol. 8, Issue 12) Peer-ReviewedThe ability of cells toad here to each other and to their surrounding extracellular matrices is essential for a multicellular existence. Adhesion provides physical support for cells, regulates cell positioning and...
- 17From: Nature Reviews Molecular Cell Biology. (Vol. 8, Issue 12) Peer-ReviewedThe chromosomal passenger complex (CPC) regulates several mitotic events, including chromosome segregation and cytokinesis. The CPC consists of Aurora-B kinase and three regulatory subunits: INCENP, survivin and...
- 18From: Nature Reviews Molecular Cell Biology. (Vol. 8, Issue 12) Peer-ReviewedThe polycomb group (PcG) gene BMI1, which is required for proliferation of both differentiated cells and adult stem cells, is overexpressed in various cancers and acts as an oncogene. Its oncogenic function has been...
- 19From: Nature Reviews Molecular Cell Biology. (Vol. 8, Issue 12) Peer-ReviewedHow tumour cells invade the surrounding tissue remains an open question in cancer biology. While various models exist, a popular concept being the epithelial-to-mesenchymal transition, Erik Sahai and colleagues now...