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Academic Journals
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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 8AndIssue Number: 11AndStart Page: e1003077AndDate: 2012 Revise Search
- 1From: PLoS Genetics. (Vol. 8, Issue 11) Peer-ReviewedEscherichia coli pol V (UmuD'[sub.2]C), the main translesion DNA polymerase, ensures continued nascent strand extension when the cellular replicase is blocked by unrepaired DNA lesions. Pol V is characterized by low...
- 2From: PLoS Genetics. (Vol. 8, Issue 11) Peer-ReviewedChloroquine (CQ) and other quinoline-containing antimalarials are important drugs with many therapeutic benefits as well as adverse effects. However, the molecular targets underlying most such effects are largely...
- 3From: PLoS Genetics. (Vol. 8, Issue 11) Peer-ReviewedCHTF18 (chromosome transmission fidelity factor 18) is an evolutionarily conserved subunit of the Replication Factor C-like complex, CTF18-RLC. CHTF18 is necessary for the faithful passage of chromosomes from one...
- 4From: PLoS Genetics. (Vol. 8, Issue 11) Peer-ReviewedMyotonic dystrophy type 1 (DM1) is caused by an unstable CTG repeat expansion in the 3'UTR of the DM protein kinase (DMPK) gene. DMPK transcripts carrying CUG expansions form nuclear foci and affect splicing regulation...
- 5From: PLoS Genetics. (Vol. 8, Issue 11) Peer-ReviewedH2A.Z is an essential histone variant that has been implicated to have multiple chromosomal functions. To understand how H2A.Z participates in such diverse activities, we sought to identify downstream effector proteins...
- 6From: PLoS Genetics. (Vol. 8, Issue 11) Peer-ReviewedFusion and fission of mitochondria maintain the functional integrity of mitochondria and protect against neurodegeneration, but how mitochondrial dysfunctions trigger neuronal loss remains ill-defined. Prohibitins form...
- 7From: PLoS Genetics. (Vol. 8, Issue 11) Peer-ReviewedDimethylation of histone H3 lysine 9 (H3K9m2) and trimethylation of histone H3 lysine 27 (H3K27m3) are two hallmarks of transcriptional repression in many organisms. In Arabidopsis thaliana, H3K27m3 is targeted by...
- 8From: PLoS Genetics. (Vol. 8, Issue 11) Peer-ReviewedDNA polymerase [beta] (Pol[beta]) is recognized as an essential DNA repair protein [1,2]. Although the smallest of the human DNA polymerases [3,4], this 335-amino-acid protein is the primary DNA polymerase in the base...
- 9From: PLoS Genetics. (Vol. 8, Issue 11) Peer-ReviewedGenomes contain tandem repeats that are at risk of internal rearrangements and a threat to genome integrity. Here, we investigated the behavior of the human subtelomeric minisatellites HRAS1, CEB1, and CEB25 in...
- 10From: PLoS Genetics. (Vol. 8, Issue 11) Peer-ReviewedNasopharyngeal carcinoma (NPC) is an epithelial malignancy facilitated by Epstein-Barr Virus infection. Here we resolve the major genetic influences for NPC incidence using a genome-wide association study (GWAS),...
- 11From: PLoS Genetics. (Vol. 8, Issue 11) Peer-ReviewedCaenorhabditis elegans male copulation requires coordinated temporal-spatial execution of different motor outputs. During mating, a cloacal circuit consisting of cholinergic sensory-motor neurons and sex muscles...
- 12From: PLoS Genetics. (Vol. 8, Issue 11) Peer-ReviewedThe Dobzhansky-Muller model of incompatibilities explains reproductive isolation between species by incorrect epistatic interactions. Although the mechanisms of speciation are of great interest, no incompatibility has...
- 13From: PLoS Genetics. (Vol. 8, Issue 11) Peer-ReviewedA Drosophila transgenic RNAi screen targeting the glycan genome, including all N/O/GAG-glycan biosynthesis/modification enzymes and glycan-binding lectins, was conducted to discover novel glycan functions in...
- 14From: PLoS Genetics. (Vol. 8, Issue 11) Peer-ReviewedThe procambium and cambium are meristematic tissues from which vascular tissue is derived. Vascular initials differentiate into phloem towards the outside of the stem and xylem towards the inside. A small peptide...
- 15From: PLoS Genetics. (Vol. 8, Issue 11) Peer-Reviewed[SNAP.sub.c] is one of a few basal transcription factors used by both RNA polymerase (pol) II and pol III. To define the set of active [SNAP.sub.c]-dependent promoters in human cells, we have localized genome-wide four...
- 16From: PLoS Genetics. (Vol. 8, Issue 11) Peer-ReviewedCardiac aging is a complex process, which is influenced by both environmental and genetic factors. Deciphering the mechanisms involved in heart senescence therefore requires identifying the molecular pathways that are...
- 17From: PLoS Genetics. (Vol. 8, Issue 11) Peer-ReviewedGenetically tractable model organisms from phages to mice have taught us invaluable lessons about fundamental biological processes and disease-causing mutations. Owing to technological and computational advances, human...
- 18From: PLoS Genetics. (Vol. 8, Issue 11) Peer-ReviewedUnderstanding the relationship between genetic and phenotypic variation is one of the great outstanding challenges in biology. To meet this challenge, comprehensive genomic variation maps of human as well as of model...
- 19From: PLoS Genetics. (Vol. 8, Issue 11) Peer-ReviewedHereditary spastic paraplegias (HSPs) comprise a group of genetically heterogeneous neurodegenerative disorders characterized by spastic weakness of the lower extremities. We have generated a Drosophila model for HSP...
- 20From: PLoS Genetics. (Vol. 8, Issue 11) Peer-ReviewedThe seed maturation program only occurs during late embryogenesis, and repression of the program is pivotal for seedling development. However, the mechanism through which this repression is achieved in vegetative...