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- 1From: PLoS Computational Biology. (Vol. 8, Issue 10) Peer-ReviewedWe describe methods for rapid sequencing of the entire human mitochondrial genome (mtgenome), which involve long-range PCR for specific amplification of the mtgenome, pyrosequencing, quantitative mapping of sequence...
- 2From: PLoS Computational Biology. (Vol. 8, Issue 10) Peer-Reviewed
Coding and decoding with adapting neurons: a population approach to the Peri-Stimulus time histogram
The response of a neuron to a time-dependent stimulus, as measured in a Peri-Stimulus-Time-Histogram (PSTH), exhibits an intricate temporal structure that reflects potential temporal coding principles. Here we analyze... - 3From: PLoS Computational Biology. (Vol. 8, Issue 10) Peer-ReviewedThe ability to examine the behavior of biological systems in silico has the potential to greatly accelerate the pace of discovery in diseases, such as stroke, where in vivo analysis is time intensive and costly. In this...
- 4From: PLoS Computational Biology. (Vol. 8, Issue 10) Peer-ReviewedBone is a common site for cancer metastasis. To create space for their growth, cancer cells stimulate bone resorbing osteoclasts. Cytokine RANKL is a key osteoclast activator, while osteoprotegerin (OPG) is a RANKL...
- 5From: PLoS Computational Biology. (Vol. 8, Issue 10) Peer-ReviewedThere is accumulating evidence that prior knowledge about expectations plays an important role in perception. The Bayesian framework is the standard computational approach to explain how prior knowledge about the...
- 6From: PLoS Computational Biology. (Vol. 8, Issue 10) Peer-ReviewedWith much trepidation I accepted the great honor and responsibility of becoming Editor-in-Chief of PLOS Computational Biology. I am fully aware of how hard it will be to step into the shoes of Philip Bourne, the...
- 7From: PLoS Computational Biology. (Vol. 8, Issue 10) Peer-ReviewedRecent serological studies of seasonal influenza A in humans suggest a striking characteristic profile of immunity against age, which holds across different countries and against different subtypes of influenza. For...
- 8From: PLoS Computational Biology. (Vol. 8, Issue 10) Peer-ReviewedPlace cells in the hippocampus of higher mammals are critical for spatial navigation. Recent modeling clarifies how this may be achieved by how grid cells in the medial entorhinal cortex (MEC) input to place cells. Grid...
- 9From: PLoS Computational Biology. (Vol. 8, Issue 10) Peer-ReviewedWhile sensory neurons carry behaviorally relevant information in responses that often extend over hundreds of milliseconds, the key units of neural information likely consist of much shorter and temporally precise spike...
- 10From: PLoS Computational Biology. (Vol. 8, Issue 10) Peer-ReviewedThere is ample empirical evidence revealing that fitness landscapes are often complex: the fitness effect of a newly arisen mutation can depend strongly on the allelic state at other loci. However, little is known about...
- 11From: PLoS Computational Biology. (Vol. 8, Issue 10) Peer-ReviewedThe effects of disease mutations on protein structure and function have been extensively investigated, and many predictors of the functional impact of single amino acid substitutions are publicly available. The majority...
- 12From: PLoS Computational Biology. (Vol. 8, Issue 10) Peer-ReviewedGauging the systemic effects of non-synonymous single nucleotide polymorphisms (nsSNPs) is an important topic in the pursuit of personalized medicine. However, it is a non-trivial task to understand how a change at the...
- 13From: PLoS Computational Biology. (Vol. 8, Issue 10) Peer-ReviewedWe are interested in how intragenic recombination contributes to the evolution of proteins and how this mechanism complements and enhances the diversity generated by random mutation. Experiments have revealed that...
- 14From: PLoS Computational Biology. (Vol. 8, Issue 10) Peer-ReviewedThe healing of a fracture depends largely on the development of a new blood vessel network (angiogenesis) in the callus. During angiogenesis tip cells lead the developing sprout in response to extracellular signals,...
- 15From: PLoS Computational Biology. (Vol. 8, Issue 10) Peer-ReviewedEfforts to reduce the viral load of human immunodeficiency virus type 1 (HIV-1) during long-term treatment are challenged by the evolution of anti-viral resistance mutants. Recent studies have shown that gene therapy...
- 16From: PLoS Computational Biology. (Vol. 8, Issue 10) Peer-ReviewedViral replication relies on host metabolic machinery and precursors to produce large numbers of progeny--often very rapidly. A fundamental example is the infection of Escherichia coli by bacteriophage T7. The resource...
- 17From: PLoS Computational Biology. (Vol. 8, Issue 10) Peer-ReviewedAfter seven years as the Editor-in-Chief of PLOS Computational Biology, I have decided to step to the side. It's time to bring in new leadership and a new vision. As scientists we generally do not learn a lot of...
- 18From: PLoS Computational Biology. (Vol. 8, Issue 10) Peer-ReviewedThe pre-fibrillar stages of amyloid formation have been implicated in cellular toxicity, but have proved to be challenging to study directly in experiments and simulations. Rational strategies to suppress the formation...
- 19From: PLoS Computational Biology. (Vol. 8, Issue 10) Peer-ReviewedWe examined an eye-hand coordination task where optimal visual search and hand movement strategies were inter-related. Observers were asked to find and touch a target among five distractors on a touch screen. Their...
- 20From: PLoS Computational Biology. (Vol. 8, Issue 10) Peer-ReviewedA next generation approach to cancer envisions developing preventative vaccinations to stimulate a person's immune cells, particularly cytotoxic T lymphocytes (CTLs), to eliminate incipient tumors before clinical...