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- 1From: Nature Reviews Neurology. (Vol. 8, Issue 1) Peer-ReviewedArterial spin-labeled perfusion MRI (ASL-MRI) has comparable sensitivity and specificity to fluorodeoxyglucose PET (FDG-PET) imaging to detect functional changes in the brain and provide a basis for the diagnosis of...
- 2From: Nature Reviews Neurology. (Vol. 8, Issue 1) Peer-ReviewedStatins have been shown to aid both primary and secondary stroke prevention, but little is known about the efficacy of these drugs in the acute stroke setting. Alexander Flint and his colleagues at Kaiser Permanente and...
- 3From: Nature Reviews Neurology. (Vol. 8, Issue 1) Peer-ReviewedAn RNA microarray study has demonstrated specific gene expression patterns in the blood of patients who have recently experienced a transient ischemic attack (TIA). 449 genes were found to be differentially expressed...
- 4From: Nature Reviews Neurology. (Vol. 8, Issue 1) Peer-ReviewedThe putative mitochondrial modulator dexpramipexole seems to slow functional decline and might reduce mortality in patients with amyotrophic lateral sclerosis (ALS), according to a phase II study. ALS is a fatal...
- 5From: Nature Reviews Neurology. (Vol. 8, Issue 1) Peer-ReviewedDepression occurs in around 35% of patients with Parkinson disease (PD) and is often persistent. Symptoms of depression can be evident in individuals at the time of diagnosis and might develop in the premotor stage of...
- 6From: Nature Reviews Neurology. (Vol. 8, Issue 1) Peer-ReviewedThe use of antipsychotic medication to treat people with dementia has become something of a cause celebre in recent years after an authoritative report highlighted the excess mortality associated with the use of these...
- 7From: Nature Reviews Neurology. (Vol. 8, Issue 1) Peer-ReviewedParkinson disease (PD) is a prevalent neurodegenerative disease that causes both motor and nonmotor symptoms. Over the past two decades, concern has been raised that levodopa--the gold-standard therapy for patients with...
- 8From: Nature Reviews Neurology. (Vol. 8, Issue 1) Peer-ReviewedSpinocerebellar ataxia type 1 (SCA1) is caused by a CAG repeat expansion in the ataxin-1 (ATXN1) gene. Experiments in a mouse model of SCA1 have now shown that the mutant ATXN1 protein represses transcription of the...
- 9From: Nature Reviews Neurology. (Vol. 8, Issue 1) Peer-ReviewedResearchers in Germany have shown that the green tea polyphenol epigallocatechin gallate (ECGC), administered in combination with laser irradiation, can reduce amyloid-[beta] aggregation in human neuroblastoma cells....
- 10From: Nature Reviews Neurology. (Vol. 8, Issue 1) Peer-ReviewedPostural tachycardia syndrome (PoTS) is a poorly understood but important cause of orthostatic intolerance resulting from cardiovascular autonomic dysfunction. PoTS is distinct from the syndromes of autonomic failure...
- 11From: Nature Reviews Neurology. (Vol. 8, Issue 1) Peer-ReviewedA new cross-sectional study proposes three subtypes of Alzheimer disease: hippocampal-sparing, typical and limbic-predominant, associated with average lifespans of 72, 79 and 86 years, respectively. A longitudinal view...
- 12From: Nature Reviews Neurology. (Vol. 8, Issue 1) Peer-ReviewedSpontaneous intracranial hypotension (SIH) syndrome can be difficult to diagnose, and standard MRI techniques are not particularly effective at detecting the cerebrospinal fluid (CSF) leaks that characterize this...
- 13From: Nature Reviews Neurology. (Vol. 8, Issue 1) Peer-ReviewedA Korean study involving 752 patients with acute ischemic stroke has found a significant association between high serum ferritin levels and hemorrhagic transformation, a serious complication that can counteract the...
- 14From: Nature Reviews Neurology. (Vol. 8, Issue 1) Peer-ReviewedNeurological markers are used to predict outcomes in patients resuscitated after cardiac arrest, and are crucial in informing treatment decisions in comatose patients. A multicenter study reports that therapeutic...
- 15From: Nature Reviews Neurology. (Vol. 8, Issue 1) Peer-ReviewedMultifocal motor neuropathy (MMN) is a rare inflammatory neuropathy characterized by slowly progressive, asymmetric distal limb weakness without sensory loss. The clinical presentation of MMN may mimic amyotrophic...
- 16From: Nature Reviews Neurology. (Vol. 8, Issue 1) Peer-ReviewedPrevious studies using magnetic resonance spectroscopy have shown that N-acetylaspartate (NAA) levels are reduced in the brains of patients with amyotrophic lateral sclerosis (ALS). New research indicates that this...
- 17From: Nature Reviews Neurology. (Vol. 8, Issue 1) Peer-ReviewedA solvent that is used in a wide range of household products and is present as an environmental contaminant in groundwater could increase the risk of developing Parkinson disease (PD), according to a twin study. A...
- 18From: Nature Reviews Neurology. (Vol. 8, Issue 1) Peer-ReviewedIn a new study, published in PNAS, Couthouis et al. used a yeast functional screen, in combination with biochemical, neuronal cell culture, Drosophila and human genetic studies, to identify novel candidate...
- 19From: Nature Reviews Neurology. (Vol. 8, Issue 1) Peer-ReviewedA new two-center study provides support for the use of intravenous dexamethasone in patients with acute hemorrhagic stroke--a treatment strategy that is employed routinely at the University Hospital of Heraklion, Crete...
- 20From: Nature Reviews Neurology. (Vol. 8, Issue 1) Peer-ReviewedDespite promising phase II results, a phase III trial has failed to confirm that the dopaminergic stabilizer pridopidine improves motor function in patients with Huntington disease (HD). In the randomized, double-blind,...