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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 8AndIssue Number: 1AndStart Page: e1002457AndDate: 2012 Revise Search
- 1From: PLoS Genetics. (Vol. 8, Issue 1) Peer-ReviewedBile possesses antibacterial activity because bile salts disrupt membranes, denature proteins, and damage DNA. This study describes mechanisms employed by the bacterium Salmonella enterica to survive bile. Sublethal...
- 2From: PLoS Genetics. (Vol. 8, Issue 1) Peer-ReviewedChanges in the spatial positioning of genes within the mammalian nucleus have been associated with transcriptional differences and thus have been hypothesized as a mode of regulation. In particular, the localization of...
- 3From: PLoS Genetics. (Vol. 8, Issue 1) Peer-ReviewedGene expression is subject to random perturbations that lead to fluctuations in the rate of protein production. As a consequence, for any given protein, genetically identical organisms living in a constant environment...
- 4From: PLoS Genetics. (Vol. 8, Issue 1) Peer-ReviewedPerennial questions of evolutionary biology can be applied to gene regulatory systems using the abundance of experimental data addressing gene regulation in a comparative context. What is the tempo (frequency, rate) and...
- 5From: PLoS Genetics. (Vol. 8, Issue 1) Peer-ReviewedIdentifying the genes that influence levels of pro-inflammatory molecules can help to elucidate the mechanisms underlying this process. We first conducted a two-stage genome-wide association scan (GWAS) for the key...
- 6From: PLoS Genetics. (Vol. 8, Issue 1) Peer-ReviewedThe Arabidopsis thaliana Somatic Embryogenesis Receptor Kinases (SERKs) consist of five members, SERK1 to SERK5, of the leucine-rich repeat receptor-like kinase subfamily II (LRR-RLK II). SERK3 was named BRI1-Associated...
- 7From: PLoS Genetics. (Vol. 8, Issue 1) Peer-ReviewedAlthough bacteria with multipartite genomes are prevalent, our knowledge of the mechanisms maintaining their genome is very limited, and much remains to be learned about the structural and functional interrelationships...
- 8From: PLoS Genetics. (Vol. 8, Issue 1) Peer-ReviewedThe domestic dog (Canis familiaris) segregates more naturally-occurring diseases and phenotypic variation than any other species and has become established as an unparalled model with which to study the genetics of...
- 9From: PLoS Genetics. (Vol. 8, Issue 1) Peer-ReviewedRecent studies have revealed an important role for hormones in plant immunity. We are now beginning to understand the contribution of crosstalk among different hormone signaling networks to the outcome of plant-pathogen...
- 10From: PLoS Genetics. (Vol. 8, Issue 1) Peer-ReviewedNorth African populations are distinct from sub-Saharan Africans based on cultural, linguistic, and phenotypic attributes; however, the time and the extent of genetic divergence between populations north and south of...
- 11From: PLoS Genetics. (Vol. 8, Issue 1) Peer-ReviewedChromatin undergoes major remodeling around DNA double-strand breaks (DSB) to promote repair and DNA damage response (DDR) activation. We recently reported a high-resolution map of [gamma]H2AX around multiple breaks on...
- 12From: PLoS Genetics. (Vol. 8, Issue 1) Peer-ReviewedAdaptation to novel environments is often associated with changes in gene regulation. Nevertheless, few studies have been able both to identify the genetic basis of changes in regulation and to demonstrate why these...
- 13From: PLoS Genetics. (Vol. 8, Issue 1) Peer-ReviewedAn important function of all organisms is to ensure that their genetic material remains intact and unaltered through generations. This is an extremely challenging task since the cell's DNA is constantly under assault by...
- 14From: PLoS Genetics. (Vol. 8, Issue 1) Peer-ReviewedPink1 is a mitochondrial kinase involved in Parkinson's disease, and loss of Pink1 function affects mitochondrial morphology via a pathway involving Parkin and components of the mitochondrial remodeling machinery. Pink1...
- 15From: PLoS Genetics. (Vol. 8, Issue 1) Peer-ReviewedIn 1962, Hamilton Smith abandoned a career in medicine to follow his passion for the emerging field of molecular biology; within six years, he had made the discovery of a lifetime. As a new Johns Hopkins faculty member,...
- 16From: PLoS Genetics. (Vol. 8, Issue 1) Peer-ReviewedAn important follow-up step after genetic markers are found to be associated with a disease outcome is a more detailed analysis investigating how the implicated gene or chromosomal region and an established environment...
- 17From: PLoS Genetics. (Vol. 8, Issue 1) Peer-ReviewedAll eukaryotes have the ability to detect and respond to environmental and hormonal signals. In many cases these signals evoke cellular changes that are incompatible and must therefore be orchestrated by the responding...
- 18From: PLoS Genetics. (Vol. 8, Issue 1) Peer-ReviewedMicroRNAs (miRNAs) are ~21 nt small RNAs that regulate gene expression in animals and plants. They can be grouped into families comprising different genes encoding similar or identical mature miRNAs. Several miRNA...
- 19From: PLoS Genetics. (Vol. 8, Issue 1) Peer-ReviewedThe prevalence of type 2 diabetes in the United States is projected to double or triple by 2050. We reasoned that the genes that modulate insulin production might be new targets for diabetes therapeutics. Therefore, we...
- 20From: PLoS Genetics. (Vol. 8, Issue 1) Peer-ReviewedSecretion of neurotransmitters and neuropeptides is mediated by exocytosis of distinct secretory organelles, synaptic vesicles (SVs) and dense core vesicles (DCVs) respectively. Relatively little is known about factors...