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- 1From: PLoS Pathogens. (Vol. 8, Issue 1) Peer-ReviewedThe hemagglutinin-esterases (HEs), envelope glycoproteins of corona-, toro- and orthomyxoviruses, mediate reversible virion attachment to O-acetylated sialic acids (O-Ac-Sias). They do so through concerted action of...
- 2From: PLoS Pathogens. (Vol. 8, Issue 1) Peer-ReviewedThe rymv1-2 and rymv1-3 alleles of the RYMV1 resistance to Rice yellow mottle virus (RYMV), coded by an eIF(iso)4G1 gene, occur in a few cultivars of the Asiatic (Oryza sativa) and African (O. glaberrima) rice species,...
- 3From: PLoS Pathogens. (Vol. 8, Issue 1) Peer-ReviewedThe Mitochondrial Carrier Family (MCF) is a signature group of integral membrane proteins that transport metabolites across the mitochondrial inner membrane in eukaryotes. MCF proteins are characterized by six...
- 4From: PLoS Pathogens. (Vol. 8, Issue 1) Peer-ReviewedKaposi's sarcoma-associated herpesvirus (KSHV) is tightly linked to at least two lymphoproliferative disorders, primary effusion lymphoma (PEL) and multicentric Castleman's disease (MCD). However, the development of...
- 5From: PLoS Pathogens. (Vol. 8, Issue 1) Peer-ReviewedVibrio cholera is a bacterial pathogen that colonizes the chitinous exoskeleton of zooplankton as well as the human gastrointestinal tract. Colonization of these different niches involves an N-acetylglucosamine binding...
- 6From: PLoS Pathogens. (Vol. 8, Issue 1) Peer-ReviewedThe availability of genome sequences for some of the most devastating eukaryotic plant pathogens has led a revolution in our understanding of how these parasites cause disease, and how their hosts respond to invasion...
- 7From: PLoS Pathogens. (Vol. 8, Issue 1) Peer-ReviewedNK cells are important immune effectors for preventing microbial invasion and dissemination, through natural cytotoxicity and cytokine secretion. Bacillus anthracis spores can efficiently drive IFN-[gamma] production by...
- 8From: PLoS Pathogens. (Vol. 8, Issue 1) Peer-ReviewedEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus linked to a number of B cell cancers and lymphoproliferative disorders. During latent infection, EBV expresses 25 viral pre-microRNAs (miRNAs) and induces the...
- 9From: PLoS Pathogens. (Vol. 8, Issue 1) Peer-ReviewedHuman interferon (IFN)-inducible IFI16 protein, an innate immune sensor of intracellular DNA, modulates various cell functions, however, its role in regulating virus growth remains unresolved. Here, we adopt two...
- 10From: PLoS Pathogens. (Vol. 8, Issue 1) Peer-ReviewedHCV infection is a major risk factor for liver cancer and liver transplantation worldwide. Overstimulation of host lipid metabolism in the liver by HCV-encoded proteins during viral infection creates a favorable...
- 11From: PLoS Pathogens. (Vol. 8, Issue 1) Peer-ReviewedHighly active antiretroviral therapy (HAART) can suppress HIV-1 replication and normalize the chronic immune activation associated with infection, but restoration of naive [CD4.SUP.+] T cell populations is slow and...
- 12From: PLoS Pathogens. (Vol. 8, Issue 1) Peer-ReviewedIn schistosomiasis patients, parasite eggs trapped in hepatic sinusoids become foci for [CD4.sup.+] T cell-orchestrated granulomatous cellular infiltrates. Since the immune response is unable to clear the infection, the...
- 13From: PLoS Pathogens. (Vol. 8, Issue 1) Peer-ReviewedType 1 interferons (T1-IFNs) play a major role in antiviral defense, but when or how they protect during infections that spread through the lympho-hematogenous route is not known. Orthopoxviruses, including those that...
- 14From: PLoS Pathogens. (Vol. 8, Issue 1) Peer-ReviewedThe clinicopathological features of the hamster model of visceral leishmaniasis (VL) closely mimic active human disease. Studies in humans and hamsters indicate that the inability to control parasite replication in VL...
- 15From: PLoS Pathogens. (Vol. 8, Issue 1) Peer-ReviewedUpon attachment to their respective receptor, human rhinoviruses (HRVs) are internalized into the host cell via different pathways but undergo similar structural changes. This ultimately results in the delivery of the...
- 16From: PLoS Pathogens. (Vol. 8, Issue 1) Peer-ReviewedHuman Cytomegalovirus (HCMV) infection induces several metabolic activities that have been found to be important for viral replication. The cellular AMP-activated protein kinase (AMPK) is a metabolic stress response...
- 17From: PLoS Pathogens. (Vol. 8, Issue 1) Peer-Reviewed
Two-drug antimicrobial chemotherapy: a mathematical model and experiments with Mycobacterium marinum
Multi-drug therapy is the standard-of-care treatment for tuberculosis. Despite this, virtually all studies of the pharmacodynamics (PD) of mycobacterial drugs employed for the design of treatment protocols are... - 18From: PLoS Pathogens. (Vol. 8, Issue 1) Peer-ReviewedThe current model of hepatitis C virus (HCV) production involves the assembly of virions on or near the surface of lipid droplets, envelopment at the ER in association with components of VLDL synthesis, and egress via...
- 19From: PLoS Pathogens. (Vol. 8, Issue 1) Peer-ReviewedType 1 interferons (IFNs) were the first cytokines discovered and include IFN[beta], >ten forms of IFN[alpha], and several other related molecules that all bind to the same type 1 IFN receptor (IFN1R). Type 1 IFNs are...
- 20From: PLoS Pathogens. (Vol. 8, Issue 1) Peer-ReviewedDissemination of HIV in the host involves transit of the virus and virus-infected cells across the lymphatic endothelium. HIV may alter lymphatic endothelial permeability to foster dissemination, but the mechanism is...