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- 1From: AIDS Research and Therapy. (Vol. 8) Peer-ReviewedBackground Combinatorial RNA interference (co-RNAi) approaches are needed to account for viral variability in treating HIV-1 with RNAi, as single short hairpin RNAs (shRNA) are rapidly rendered ineffective by...
- 2From: AIDS Research and Therapy. (Vol. 8) Peer-ReviewedBackground HAART has significantly reduced AIDS-related morbidity in children. However, limited evidence is available from developing countries regarding patterns of opportunistic illnesses. We describe these events...
- 3From: AIDS Research and Therapy. (Vol. 8) Peer-ReviewedBackground Effective interventions to prevent mother-to-child HIV transmission (PMTCT) exist and when properly applied reduce the risk of vertical HIV transmission. As part of optimizing PMTCT in the Dutch Caribbean...
- 4From: AIDS Research and Therapy. (Vol. 8) Peer-ReviewedBackground We aimed to determine the reliability and validity of a hepatitis symptom inventory and to identify predictors of hepatitis C (HCV) treatment initiation in a cohort of HIV-infected patients. Methods...
- 5From: AIDS Research and Therapy. (Vol. 8) Peer-ReviewedBackground RC-101, a cationic peptide retrocyclin analog, has in vitro activity against HIV-1. Peptide drugs are commonly prone to conformational changes, oxidation and hydrolysis when exposed to excipients in a...
- 6From: AIDS Research and Therapy. (Vol. 8) Peer-ReviewedBackground Genotype-derived drug resistance profiles are a valuable asset in HIV-1 therapy decisions. Therapy decisions could be further improved, both in terms of predicting length of current therapy success and in...
- 7From: AIDS Research and Therapy. (Vol. 8) Peer-ReviewedBackground CD4+ T lymphocyte counts are the most important indicator of disease progression and success of antiretroviral treatment in HIV infection in resource limited settings. The nationwide reference range of...
- 8From: AIDS Research and Therapy. (Vol. 8) Peer-ReviewedBackground Separately, chronic alcohol ingestion and HIV-1 infection are associated with severe skeletal muscle derangements, including atrophy and wasting, weakness, and fatigue. One prospective cohort study...
- 9From: AIDS Research and Therapy. (Vol. 8) Peer-ReviewedBackground Highly Active Antiretroviral Therapy (HAART) has been available free of charge in Tanga, Tanzania since 2005. However we have found that a high percentage of women referred from prevention of...
- 10From: AIDS Research and Therapy. (Vol. 8) Peer-ReviewedBackground Minocycline is a tetracycline antibiotic that has been shown to attenuate central nervous system (CNS) lentivirus infection, immune activation, and brain injury in model systems. To initiate assessment of...
- 11From: AIDS Research and Therapy. (Vol. 8) Peer-ReviewedWe describe two patients who did not experience a viral rebound after cessation of HAART which was initiated for progressive disease. CD4 T-cell count remained stable in one patient and progressively declined in the...
- 12From: AIDS Research and Therapy. (Vol. 8) Peer-ReviewedBackground High early mortality rate among HIV infected patients following initiation of antiretroviral therapy (ART) in resource limited settings may indicate high pre-treatment mortality among ART-eligible...
- 13From: AIDS Research and Therapy. (Vol. 8) Peer-ReviewedBackground Rifampicin reduces the plasma concentrations of nevirapine in human immunodeficiency virus (HIV) and tuberculosis (TB) co-infected patients, who are administered these drugs concomitantly. We conducted a...
- 14From: AIDS Research and Therapy. (Vol. 8) Peer-ReviewedBackground There have been few reports of long-term survival of HIV-infected patients on antiretroviral therapy (ART) in Africa managed under near normal health service conditions. Methods Participants starting...
- 15From: AIDS Research and Therapy. (Vol. 8) Peer-ReviewedIn HIV-1 infected patients, increase of liver enzymes may be mainly due to viral coinfections, alcohol intake, hepatotoxic drugs or autoimmune diseases. Three cases of aminotransferase elevation occurred during a phase...
- 16From: AIDS Research and Therapy. (Vol. 8) Peer-ReviewedBackground CD8+ T cells may play an important role in protecting against HIV. However, the changes of CD8+ T cell subsets during early period of ART have not been fully studied. Methods Twenty-one asymptomatic...
- 17From: AIDS Research and Therapy. (Vol. 8) Peer-ReviewedBackground Early diagnosis of HIV infection can prevent morbidity and mortality as well as reduce HIV transmission. The aim of the present study was to assess prevalence, describe trends and identify factors...
- 18From: AIDS Research and Therapy. (Vol. 8) Peer-ReviewedBackground Drug resistance testing before initiation of, or during, antiretroviral therapy (ART) is not routinely performed in resource-limited settings. High levels of viral resistance circulating within the...
- 19From: AIDS Research and Therapy. (Vol. 8) Peer-ReviewedBackground Behaviour change which is highly influenced by risk perception is a major challenge that HIV prevention efforts need to confront. In this study, we examined the validity of self-reported likelihood of HIV...
- 20From: AIDS Research and Therapy. (Vol. 8) Peer-ReviewedSexual behavior of HIV-positive youths, whether infected perinatally, through risky behavior or other ways, is not substantially different from that of HIV-uninfected peers. Because of highly active antiretroviral...