Showing Results for
- Academic Journals (86)
Search Results
- 86
Academic Journals
- 86
- Search Terms:
- 1From: Molecular Pain. (Vol. 8) Peer-ReviewedBackground Paw carrageenan induces activation of phosphatidylinositol 3-kinase (PI-3K) and Akt in dorsal horn neurons in addition to induction of pain behavior. Spinal PI-3K activation is also thought to be required...
- 2From: Molecular Pain. (Vol. 8, Issue 1) Peer-ReviewedBackground The 5% Lidocaine patch is used for treating chronic neuropathic pain conditions such as chronic back pain (CBP), diabetic neuropathy and complex regional pain syndrome, but is effective in a variable...
- 3From: Molecular Pain. (Vol. 8, Issue 1) Peer-ReviewedBackground A small proportion of lamina I neurons of the spinal cord project upon the hindbrain and are thought to engage descending pathways that modulate the behavioural response to peripheral injury. Early...
- 4From: Molecular Pain. (Vol. 8, Issue 1) Peer-ReviewedBackground Our previous studies have shown that complete Freund's adjuvant (CFA)-induced masseter inflammation and microinjection of the pro-inflammatory cytokine interleukin-1[beta] (IL-1[beta]) into the subnucleus...
- 5From: Molecular Pain. (Vol. 8, Issue 1) Peer-ReviewedThe subcutaneous and systemic injection of serotonin reduces cutaneous and visceral pain thresholds and increases responses to noxious stimuli. Different subtypes of 5-hydroxytryptamine (5-HT) receptors are suggested to...
- 6From: Molecular Pain. (Vol. 8, Issue 1) Peer-ReviewedBackground Galanin is a key modulator of nociception, and it is also required for the developmental survival of a subset of C-fibre sensory neurons which are critical to the mediation of neuropathic and inflammatory...
- 7From: Molecular Pain. (Vol. 8, Issue 1) Peer-ReviewedBackground To determine the effects of inferior alveolar nerve transection (IAN-X) on masticatory movements in freely moving rats and to test if microglial cells in the trigeminal principal sensory nucleus (prV) or...
- 8From: Molecular Pain. (Vol. 8, Issue 1) Peer-ReviewedBackground Itch is one of the major somatosensory modalities. Some recent findings have proposed that gastrin releasing peptide (Grp) is expressed in a subset of dorsal root ganglion (DRG) neurons and functions as a...
- 9From: Molecular Pain. (Vol. 8, Issue 1) Peer-ReviewedBackground 5-hydroxytryptamine (5-HT) is one of the major neurotransmitters widely distributed in the CNS. Several 5-HT receptor subtypes have been identified in the spinal dorsal horn which act on both pre- and...
- 10From: Molecular Pain. (Vol. 8, Issue 1) Peer-ReviewedBackground Sickle cell disease (SCD) is associated with both acute vaso-occlusive painful events as well as chronic pain syndromes, including heightened sensitivity to touch. We have previously shown that mice with...
- 11From: Molecular Pain. (Vol. 8, Issue 1) Peer-ReviewedBackground The ubiquity of protein-protein interactions in biological signaling offers ample opportunities for therapeutic intervention. We previously identified a peptide, designated CBD3, that suppressed...
- 12From: Molecular Pain. (Vol. 8, Issue 1) Peer-ReviewedBackground Chemotherapeutic agents produce dose-limiting peripheral neuropathy through mechanisms that remain poorly understood. We previously showed that AM1710, a cannabilactone CB.sub.2 agonist, produces...
- 13From: Molecular Pain. (Vol. 8, Issue 1) Peer-ReviewedBackground Essential oils are often used in alternative medicine as analgesic and anti-inflammatory remedies. However, the specific compounds that confer the effects of essential oils and the molecular mechanisms are...
- 14From: Molecular Pain. (Vol. 8) Peer-ReviewedBackground Painful neuropathy is a common complication of diabetes. Previous studies have identified significant increases in the amount of voltage gated sodium channel isoforms Na.sub.V 1.7 and Na.sub.V 1.3 protein...
- 15From: Molecular Pain. (Vol. 8, Issue 1) Peer-ReviewedBackground Inflammation-induced sensitization of primary afferents is associated with a decrease in K.sup.+ current. However, the type of K.sup.+ current and basis for the decrease varies as a function of target of...
- 16From: Molecular Pain. (Vol. 8) Peer-ReviewedBackground Oxaliplatin is an important drug used in the treatment of colorectal cancer. However, it frequently causes severe acute and chronic peripheral neuropathies. We recently reported that repeated...
- 17From: Molecular Pain. (Vol. 8, Issue 1) Peer-ReviewedBackground There is evidence for augmented processing of pain and impaired endogenous pain inhibition in Fibromyalgia syndrome (FM). In order to fully understand the mechanisms involved in FM pathology, there is a...
- 18From: Molecular Pain. (Vol. 8, Issue 1) Peer-ReviewedBackground Although neuroimaging techniques have provided insights into the function of brain regions involved in Trigeminal Neuropathic Pain (TNP) in humans, there is little understanding of the molecular mechanisms...
- 19From: Molecular Pain. (Vol. 8) Peer-ReviewedBackground The purinergic P2X3 receptor (P2X3R) expressed in the dorsal root ganglion (DRG) sensory neuron and the P2X7 receptor (P2X7R) expressed in the surrounding satellite glial cell (SGC) are two major receptors...
- 20From: Molecular Pain. (Vol. 8) Peer-ReviewedBackground Despite advances in our understanding of basic mechanisms driving post-surgical pain, treating incision-induced pain remains a major clinical challenge. Moreover, surgery has been implicated as a major...