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- 1From: Journal of Translational Medicine. (Vol. 8) Peer-ReviewedBackground Tuberous Sclerosis Complex (TSC) is an autosomal dominant tumor disorder characterized by the growth of hamartomas in various organs including the kidney, brain, skin, lungs, and heart. Rapamycin has been...
- 2From: Journal of Translational Medicine. (Vol. 8) Peer-ReviewedIntroduction While adjuvant immunotherapy with Bacille Calmette Guérin (BCG) is effective in non-muscle-invasive bladder cancer (BC), adverse events (AEs) are considerable. Monocyte-derived activated killer cells (MAK)...
- 3From: Journal of Translational Medicine. (Vol. 8) Peer-ReviewedAuthors: David F Stroncek (corresponding author) [1]; Raj K Puri [2] Editorial Cell and gene therapy clinical trials began more than 40 years ago. At some institutions cellular therapy laboratories were started to...
- 4From: Journal of Translational Medicine. (Vol. 8) Peer-Reviewed
Immune signatures in human PBMCs of idiotypic vaccine for HCV-related lymphoproliferative disorders.
Hepatitis C virus (HCV) is one of the major risk factors for chronic hepatitis, which may progress to cirrhosis and hepatocellular carcinoma, as well as for type II mixed cryoglobulinemia (MC), which may further evolve... - 5From: Journal of Translational Medicine. (Vol. 8) Peer-ReviewedBackground The current paradigm for cord blood transplantation is that HLA matching and immune suppression are strictly required to prevent graft versus host disease (GVHD). Immunological arguments and historical...
- 6From: Journal of Translational Medicine. (Vol. 8) Peer-Reviewed
- 7From: Journal of Translational Medicine. (Vol. 8) Peer-ReviewedBackground Melanoma vaccines have not been optimized. Adjuvants are added to activate dendritic cells (DCs) and to induce a favourable immunologic milieu, however, little is known about their cellular and molecular...
- 8From: Journal of Translational Medicine. (Vol. 8) Peer-ReviewedBackground Colorectal cancer can be efficiently treated when found at early stages, thus the search for novel markers is of paramount importance. Since inflammation is associated with cancer progression and...
- 9From: Journal of Translational Medicine. (Vol. 8) Peer-ReviewedIn recent years the concept of "translational medicine" has been advanced in an attempt to catalyze the medical applications of basic biomedical research. However, there has been little discussion about the readiness of...
- 10From: Journal of Translational Medicine. (Vol. 8) Peer-ReviewedCorrelative studies are a primary mechanism through which insights can be obtained about the bioactivity and potential efficacy of candidate therapeutics evaluated in early-stage clinical trials. Accordingly, well...
- 11From: Journal of Translational Medicine. (Vol. 8) Peer-ReviewedBackground Efficacy of cancer vaccines may be limited due to immune escape mechanisms like loss or mutation of target antigens. Here, we analyzed 10 HLA-A2 positive patients with acute myeloid leukemia (AML) for loss...
- 12From: Journal of Translational Medicine. (Vol. 8) Peer-ReviewedBackground Little is known about the induction of humoral responses directed against human autoantigens during acute inflammation. We utilized a highly sensitive antibody profiling technology to study autoantibodies...
- 13From: Journal of Translational Medicine. (Vol. 8) Peer-ReviewedBackground According to the scientific literature, less than 30 borderline ovarian tumors have been karyotyped and less than 100 analyzed for genomic imbalances by CGH. Methods We report a series of borderline...
- 14From: Journal of Translational Medicine. (Vol. 8) Peer-ReviewedBackground Pancreatic ductal adenocarcinoma (PDAC) remains a leading cause of cancer mortality for which novel gene therapy approaches relying on tumor-tropic adenoviruses are being tested. Methods We obtained...
- 15From: Journal of Translational Medicine. (Vol. 8) Peer-ReviewedBlocking oncogenic signaling induced by the BRAF.sup.V600E .sup.mutation is a promising approach for melanoma treatment. We tested the anti-tumor effects of a specific inhibitor of Raf protein kinases, PLX4032/RG7204,...
- 16From: Journal of Translational Medicine. (Vol. 8) Peer-ReviewedBackground Pegylated granulocyte colony-stimulating factor (G-CSF; pegfilgrastim) is a longer-acting form of G-CSF, whose effects on dendritic cell (DC) and regulatory T cell (Treg) mobilization, and on the in vivo...
- 17From: Journal of Translational Medicine. (Vol. 8) Peer-ReviewedZinc is important. It is the second most abundant trace metal with 2-4 grams in humans. It is an essential trace element, critical for cell growth, development and differentiation, DNA synthesis, RNA transcription, cell...
- 18From: Journal of Translational Medicine. (Vol. 8) Peer-ReviewedBackground Type-1 T cells are critical for effective anti-tumor immune responses. The recently discovered microRNAs (miRs) are a large family of small regulatory RNAs that control diverse aspects of cell function,...
- 19From: Journal of Translational Medicine. (Vol. 8) Peer-ReviewedBackground DNA vaccines represent an attractive approach for cancer treatment by inducing active T cell and B cell immune responses to tumor antigens. Previous studies have shown that interleukin-13 receptor [alpha]2...
- 20From: Journal of Translational Medicine. (Vol. 8) Peer-ReviewedBackground Antigen-loaded dendritic cells (DC) are capable of priming naïve T cells and therefore represent an attractive adjuvant for vaccine development in anti-tumor immunotherapy. Numerous protocols have...