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- 1From: PLoS Genetics. (Vol. 7, Issue 9) Peer-ReviewedThe application of genome-wide association study (GWAS) approaches for the study of genetic determinants of common diseases has propelled human genetics forward, resulting in a surfeit of genomic data. With the...
- 2From: PLoS Genetics. (Vol. 7, Issue 9) Peer-ReviewedQuantitative genetic analysis has long been used to study how natural variation of genotype can influence an organism's phenotype. While most studies have focused on genetic determinants of phenotypic average, it is...
- 3From: PLoS Genetics. (Vol. 7, Issue 9) Peer-ReviewedTwo highly similar RNA polymerase sigma subunits, [[sigma].sup.F] and [[sigma].sup.G,] govern the early and late phases of forespore-specific gene expression during spore differentiation in Bacillus subtilis....
- 4From: PLoS Genetics. (Vol. 7, Issue 9) Peer-ReviewedNeither genetic nor environmental factors fully account for variability in individual longevity: genetically identical invertebrates in homogenous environments often experience no less variability in lifespan than...
- 5From: PLoS Genetics. (Vol. 7, Issue 9) Peer-ReviewedDrosophila melanogaster is emerging as an important model of non-pathogenic host-microbe interactions. The genetic and experimental tractability of Drosophila has led to significant gains in our understanding of...
- 6From: PLoS Genetics. (Vol. 7, Issue 9) Peer-ReviewedIn vertebrates, left-right (LR) axis specification is determined by a ciliated structure in the posterior region of the embryo. Fluid flow in this ciliated structure is responsible for the induction of unilateral...
- 7From: PLoS Genetics. (Vol. 7, Issue 9) Peer-ReviewedPMEL is an amyloidogenic protein that appears to be exclusively expressed in pigment cells and forms intralumenal fibrils within early stage melanosomes upon which eumelanins deposit in later stages. PMEL is well...
- 8From: PLoS Genetics. (Vol. 7, Issue 9) Peer-ReviewedMonozygotic (MZ) twin pair discordance for childhood-onset Type 1 Diabetes (T1D) is ~50%, implicating roles for genetic and non-genetic factors in the aetiology of this complex autoimmune disease. Although significant...
- 9From: PLoS Genetics. (Vol. 7, Issue 9) Peer-ReviewedMicroRNAs regulate networks of genes to orchestrate cellular functions. MiR-125b, the vertebrate homologue of the Caenorhabditis elegans microRNA lin-4, has been implicated in the regulation of neural and hematopoietic...
- 10From: PLoS Genetics. (Vol. 7, Issue 9) Peer-ReviewedImmense diversity of prion strains is observed, but its underlying mechanism is less clear. Three [PSI] prion strains-named VH, VK, and VL-were previously isolated in the wild-type yeast genetic background. Here we...
- 11From: PLoS Genetics. (Vol. 7, Issue 9) Peer-ReviewedMeiosis is a specialized form of cellular division that results in the precise halving of the genome to produce gametes for sexual reproduction. Checkpoints function during meiosis to detect errors and subsequently to...
- 12From: PLoS Genetics. (Vol. 7, Issue 9) Peer-Reviewed
PCNA ubiquitination is important, but not essential for translesion DNA synthesis in mammalian cells
Translesion DNA synthesis (TLS) is a DNA damage tolerance mechanism in which specialized low-fidelity DNA polymerases bypass replication-blocking lesions, and it is usually associated with mutagenesis. In Saccharomyces... - 13From: PLoS Genetics. (Vol. 7, Issue 9) Peer-ReviewedThe premature fusion of the paired frontal bones results in metopic craniosynostosis (MC) and gives rise to the clinical phenotype of trigonocephaly. Deletions of chromosome 9p22.3 are well described as a cause of MC...
- 14From: PLoS Genetics. (Vol. 7, Issue 9) Peer-ReviewedPMEL is a pigment cell-specific protein that forms physiological amyloid fibrils upon which melanins ultimately deposit in the lumen of the pigment organelle, the melanosome. Whereas hypomorphic PMEL mutations in...
- 15From: PLoS Genetics. (Vol. 7, Issue 9) Peer-Reviewed
Retrotransposon-lnduced heterochromatin spreading in the mouse revealed by insertional polymorphisms
The "arms race" relationship between transposable elements (TEs) and their host has promoted a series of epigenetic silencing mechanisms directed against TEs. Retrotransposons, a class of TEs, are often located in... - 16From: PLoS Genetics. (Vol. 7, Issue 9) Peer-ReviewedThe multifunctional Mre11-Rad50-Nbs1 (MRN) protein complex recruits ATM/Tel1 checkpoint kinase and CtIP/Ctp1 homologous recombination (HR) repair factor to double-strand breaks (DSBs). HR repair commences with the...
- 17From: PLoS Genetics. (Vol. 7, Issue 9) Peer-ReviewedSaccharomyces cerevisiae has been a powerful model for uncovering the landscape of binary gene interactions through whole-genome screening. Complex heterozygous interactions are potentially important to human genetic...
- 18From: PLoS Genetics. (Vol. 7, Issue 9) Peer-ReviewedMeiotic DNA double-strand breaks (DSBs) initiate crossover (CO) recombination, which is necessary for accurate chromosome segregation, but DSBs may also repair as non-crossovers (NCOs). Multiple recombination pathways...
- 19From: PLoS Genetics. (Vol. 7, Issue 9) Peer-ReviewedFamily studies suggest a genetic component to the etiology of chronic kidney disease (CKD) and end stage renal disease (ESRD). Previously, we identified 16 loci for eGFR in genome-wide association studies, but the...
- 20From: PLoS Genetics. (Vol. 7, Issue 9) Peer-ReviewedThe sequence and timing of permanent tooth eruption is thought to be highly heritable and can have important implications for the risk of malocclusion, crowding, and periodontal disease. We conducted a genome-wide...