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- Search Terms:ISSN: 15537366AndISSN: 15537374AndVolume Number: 7AndIssue Number: 9AndStart Page: e1002255AndDate: 2011 Revise Search
- 1From: PLoS Pathogens. (Vol. 7, Issue 9) Peer-ReviewedAntiretroviral therapy (ART) has reduced morbidity and mortality in HIV-1 infection; however HIV-1-associated neurocognitive disorders (HAND) persist despite treatment. The reasons for the limited efficacy of ART in the...
- 2From: PLoS Pathogens. (Vol. 7, Issue 9) Peer-ReviewedPhagocytosis of bacteria by innate immune cells is a primary method of bacterial clearance during infection. However, the mechanisms by which the host cell recognizes bacteria and consequentially initiates phagocytosis...
- 3From: PLoS Pathogens. (Vol. 7, Issue 9) Peer-ReviewedThe liver removes quickly the great bulk of virus circulating in blood, leaving only a small fraction to infect the host, in a manner characteristic of each virus. The scavenger cells of the liver sinusoids are...
- 4From: PLoS Pathogens. (Vol. 7, Issue 9) Peer-ReviewedNeisseria meningitidis (Nm) and N. gonorrhoeae (Ng) are adapted to different environments within their human host. If the basis of this difference has not yet been fully understood, previous studies (including our own...
- 5From: PLoS Pathogens. (Vol. 7, Issue 9) Peer-ReviewedToll-like receptor 3 (TLR3) and cytosolic RIG-I-like helicases (RIG-I and MDA5) sense viral RNAs and activate innate immune signaling pathways that induce expression of interferon (IFN) through specific adaptor...
- 6From: PLoS Pathogens. (Vol. 7, Issue 9) Peer-ReviewedPathogens switching to new hosts can result in the emergence of new infectious diseases, and determining which species are likely to be sources of such host shifts is essential to understanding disease threats to both...
- 7From: PLoS Pathogens. (Vol. 7, Issue 9) Peer-ReviewedAlteration of early haematopoietic development is thought to be responsible for the onset of immature leukemias and lymphomas. We have previously demonstrated that [Tax.sub.HTLV-1] interferes with [beta]-selection, an...
- 8From: PLoS Pathogens. (Vol. 7, Issue 9) Peer-ReviewedChikungunya virus (CHIKV) is a worldwide emerging pathogen. In humans it causes a syndrome characterized by high fever, polyarthritis, and in some cases lethal encephalitis. Growing evidence indicates that the innate...
- 9From: PLoS Pathogens. (Vol. 7, Issue 9) Peer-ReviewedUnder normal conditions the immune system has limited access to the brain;however, during toxoplasmic encephalitis (TE), large numbers of T cells and APCs accumulate within this site. A combination of real time imaging,...
- 10From: PLoS Pathogens. (Vol. 7, Issue 9) Peer-ReviewedThe cell wall is a vital and multi-functional part of bacterial cells. For Staphylococcus aureus, an important human bacterial pathogen, surface proteins and cell wall polymers are essential for adhesion, colonization...
- 11From: PLoS Pathogens. (Vol. 7, Issue 9) Peer-ReviewedWest Nile (WNV), dengue (DENV) and yellow fever (YFV) viruses are (re)emerging, mosquito-borne flaviviruses that cause human disease and mortality worldwide. Alterations in mosquito gene expression common and unique to...
- 12From: PLoS Pathogens. (Vol. 7, Issue 9) Peer-ReviewedCervical carcinomas result from cellular transformation by the human papillomavirus (HPV) E6 and E7 oncogenes which are constitutively expressed in cancer cells. The E6 oncogene degrades p53 thereby modulating a large...
- 13From: PLoS Pathogens. (Vol. 7, Issue 9) Peer-ReviewedIn the search for new drug targets, we evaluated the biotin synthetic pathway of Mycobacterium tuberculosis (Mtb) and constructed an Mtb mutant lacking the biotin biosynthetic enzyme 7,8- diaminopelargonic acid...
- 14From: PLoS Pathogens. (Vol. 7, Issue 9) Peer-ReviewedCompetence stimulating peptide (CSP) is a 17-amino acid peptide pheromone secreted by Streptococcus pneumoniae. Upon binding of CSP to its membrane-associated receptor kinase ComD, a cascade of signaling events is...
- 15From: PLoS Pathogens. (Vol. 7, Issue 9) Peer-ReviewedNematode-trapping fungi are "carnivorous" and attack their hosts using specialized trapping devices. The morphological development of these traps is the key indicator of their switch from saprophytic to predacious...
- 16From: PLoS Pathogens. (Vol. 7, Issue 9) Peer-Reviewed
Burkholderia cenocepacia BC2L-C is a super lectin with dual specificity and proinflammatory activity
Lectins and adhesins are involved in bacterial adhesion to host tissues and mucus during early steps of infection. We report the characterization of BC2L-C, a soluble lectin from the opportunistic pathogen Burkholderia... - 17From: PLoS Pathogens. (Vol. 7, Issue 9) Peer-ReviewedChlamydiae are obligate intracellular bacteria that propagate in a cytosolic vacuole. Recent work has shown that growth of Chlamydia induces the fragmentation of the Golgi apparatus (GA) into ministacks, which...
- 18From: PLoS Pathogens. (Vol. 7, Issue 9) Peer-ReviewedTuberculosis (TB) treatment is hampered by the long duration of antibiotic therapy required to achieve cure. This indolent response has been partly attributed to the ability of subpopulations of less metabolically...
- 19From: PLoS Pathogens. (Vol. 7, Issue 9) Peer-ReviewedNidoviruses with large genomes (26.3-31.7 kb;'large nidoviruses'), including Coronaviridae and Roniviridae, are the most complex positive-sense single-stranded RNA (ssRNA+) viruses. Based on genome size, they are far...
- 20From: PLoS Pathogens. (Vol. 7, Issue 9) Peer-ReviewedCD36 is the major receptor mediating nonopsonic phagocytosis of Plasmodium falciparum-parasitized erythrocytes by macrophages. Its expression on macrophages is mainly controlled by the nuclear receptor PPAR[gamma]....