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- 1From: Nature Reviews Endocrinology. (Vol. 7, Issue 8) Peer-ReviewedSystematic screening studies performed mainly in patients with diabetes mellitus have revealed an unexpectedly high prevalence of occult Cushing syndrome. Such studies may provide a rationale for systematically...
- 2From: Nature Reviews Endocrinology. (Vol. 7, Issue 8) Peer-ReviewedA recent retrospective study assessed the use of adrenal vein sampling (AVS) in conjunction with CT to help in the diagnosis of primary aldosteronism subtypes. On the basis of their findings, Sarlon-Bartoli et al....
- 3From: Nature Reviews Endocrinology. (Vol. 7, Issue 8) Peer-ReviewedTreatment options for osteoporosis are limited for older individuals with chronic kidney disease. A secondary analysis of the FREEDOM trial sheds light on the efficacy and safety of denosumab in patients with impaired...
- 4From: Nature Reviews Endocrinology. (Vol. 7, Issue 8) Peer-ReviewedAntibacterial effects of vitamin D Martin Hewison Hewison, M. Nat. Rev. Endocrinol. 7, 337-345 (2011); doi:10.1038/nrendo.2010.226 In the online and print versions of this article initially published, the...
- 5From: Nature Reviews Endocrinology. (Vol. 7, Issue 8) Peer-ReviewedNonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) frequently coexist as they share the pathogenic abnormalities of excess adiposity and insulin resistance. Although type 1 diabetes mellitus...
- 6From: Nature Reviews Endocrinology. (Vol. 7, Issue 8) Peer-ReviewedTherapy with risedronate increases BMD in women with anorexia nervosa, show the results of a randomized placebo-controlled study performed at the Massachusetts General Hospital Clinical Research Center. Anorexia...
- 7From: Nature Reviews Endocrinology. (Vol. 7, Issue 8) Peer-ReviewedNPY in the dorsomedial hypothalamus (DMH) might play a critical part in the regulation of body weight via effects on food intake, body adiposity, thermogenesis, energy expenditure and physical activity. Adipose tissue...
- 8From: Nature Reviews Endocrinology. (Vol. 7, Issue 8) Peer-ReviewedAdults aged [greater than or equal to] 70 years treated with levothyroxine have a significantly increased risk of fractures, with a strong dose-response relationship, a Canadian research group has found. Thyroid...
- 9From: Nature Reviews Endocrinology. (Vol. 7, Issue 8) Peer-Reviewed
Roux-en-Y gastric bypass corrects hyperinsulinemia implications for the remission of type 2 diabetes
In patients with T2DM after RYGB, fasting insulin levels decrease to those found in lean control individuals, and T2DM is reversed (fasting blood glucose <125 mg/dl). Reed et al. suggest that exclusion of food from the... - 10From: Nature Reviews Endocrinology. (Vol. 7, Issue 8) Peer-ReviewedLower rather than higher concentrations of circulating androgens contribute to symptoms of depression in women with polycystic ovary syndrome (PCOS), according to a study published in Psychoneuroendocrinology. A...
- 11From: Nature Reviews Endocrinology. (Vol. 7, Issue 8) Peer-ReviewedA recent report has found an association between the methylation status of specific genes in human fetal tissue and the subsequent development of childhood adiposity in two longitudinal cohorts. Would epigenetic...
- 12From: Nature Reviews Endocrinology. (Vol. 7, Issue 8) Peer-ReviewedPrimary aldosteronism is much more common than previously thought. The high prevalence of primary aldosteronism, the damage this condition does to the heart, blood vessels and kidneys (which causes a high rate of...
- 13From: Nature Reviews Endocrinology. (Vol. 7, Issue 8) Peer-ReviewedMetformin therapy can reduce the occurrence of the metabolic syndrome among overweight patients with hyperinsulinemic polycystic ovarian syndrome (PCOS) presenting with nonalcoholic fatty liver disease (NAFLD),...
- 14From: Nature Reviews Endocrinology. (Vol. 7, Issue 8) Peer-Reviewed18-Oxocortisol measurement from adrenal vein blood samples may provide a helpful biomarker for the subtype differentiation of primary aldosteronism. Distinguishing primary aldosteronism caused by an...
- 15From: Nature Reviews Endocrinology. (Vol. 7, Issue 8) Peer-ReviewedRNA interference (RNAi) is a robust gene silencing mechanism that degrades mRNAs complementary to the antisense strands of double-stranded, short interfering RNAs (siRNAs). As a therapeutic strategy, RNAi has an...
- 16From: Nature Reviews Endocrinology. (Vol. 7, Issue 8) Peer-ReviewedWomen with gestational diabetes mellitus (GDM) have an increased risk of hypertension after the pregnancy, even after adjustment for major risk factors for hypertension, new data reveal. GDM is associated with an...
- 17From: Nature Reviews Endocrinology. (Vol. 7, Issue 8) Peer-ReviewedThe use of gonadotropin-releasing hormone analogs (GnRHa) to suppress puberty in adolescents with gender dysphoria is a fairly new intervention in the field of gender identity disorders or transsexualism. GnRHa are used...
- 18From: Nature Reviews Endocrinology. (Vol. 7, Issue 8) Peer-ReviewedTwo novel mutations in the CASR gene illustrate the varying clinical effects of genetic disorders of calcium metabolism. A 16-year-old patient with mild hypercalcemia, low-normal urinary calcium excretion and...
- 19From: Nature Reviews Endocrinology. (Vol. 7, Issue 8) Peer-ReviewedThe frequency of papillary thyroid carcinoma (PTC) is increased in patients with nodular Hashimoto thyroiditis, report researchers from the University of Pisa. They also show that increased TSH levels contribute to...
- 20From: Nature Reviews Endocrinology. (Vol. 7, Issue 8) Peer-ReviewedSoluble Fms-like tyrosine kinase 1 (sFlt1)--a splice variant of the vascular endothelial growth factor receptor 1--could act as a paracrine, antiangiogenic factor to inhibit adipose tissue growth. In human...