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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 7AndIssue Number: 8AndStart Page: e1002245AndDate: 2011 Revise Search
- 1From: PLoS Genetics. (Vol. 7, Issue 8) Peer-ReviewedIn many animal species the meiosis I spindle in oocytes is anastral and lacks centrosomes. Previous studies of Drosophila oocytes failed to detect the native form of the germline-specific [gamma]-tubulin ([gamma]Tub37C)...
- 2From: PLoS Genetics. (Vol. 7, Issue 8) Peer-ReviewedPlants have a profound capacity to regenerate organs from differentiated somatic tissues, based on which propagating plants in vitro was made possible. Beside its use in biotechnology, in vitro shoot regeneration is...
- 3From: PLoS Genetics. (Vol. 7, Issue 8) Peer-ReviewedBacterial contact-dependent growth inhibition (CDI) is mediated by the CdiA/CdiB family of two-partner secretion proteins. Each CdiA protein exhibits a distinct growth inhibition activity, which resides in the...
- 4From: PLoS Genetics. (Vol. 7, Issue 8) Peer-ReviewedThe methylation of cytosines in CpG dinucleotides is essential for cellular differentiation and the progression of many cancers, and it plays an important role in gametic imprinting. To assess variation and inheritance...
- 5From: PLoS Genetics. (Vol. 7, Issue 8) Peer-ReviewedFor many complex traits, genetic variants have been found associated. However, it is still mostly unclear through which downstream mechanism these variants cause these phenotypes. Knowledge of these intermediate steps...
- 6From: PLoS Genetics. (Vol. 7, Issue 8) Peer-ReviewedThe endemic cichlid fishes in Lake Victoria are a model system for speciation through adaptive radiation. Although the evolution of the sex-determination system may also play a role in speciation, little is known about...
- 7From: PLoS Genetics. (Vol. 7, Issue 8) Peer-ReviewedCopy-number variations (CNVs) constitute very common differences between individual humans and possibly all genomes and may therefore be important fuel for evolution, yet how they form remains elusive. In starving...
- 8From: PLoS Genetics. (Vol. 7, Issue 8) Peer-ReviewedThe appearance of new mutations within a population provides the raw material for evolution. The consistent decline in fitness observed in classical mutation accumulation studies has provided support for the long-held...
- 9From: PLoS Genetics. (Vol. 7, Issue 8) Peer-ReviewedAging and longevity are considered to be highly complex genetic traits. In order to gain insight into aging as a polygenic trait, we employed an outbred Saccharomyces cerevisiae model, generated by crossing a vineyard...
- 10From: PLoS Genetics. (Vol. 7, Issue 8) Peer-ReviewedGene expression analysis has become a ubiquitous tool for studying a wide range of human diseases. In a typical analysis we compare distinct phenotypic groups and attempt to identify genes that are, on average,...
- 11From: PLoS Genetics. (Vol. 7, Issue 8) Peer-ReviewedExposure to influenza viruses is necessary, but not sufficient, for healthy human hosts to develop symptomatic illness. The host response is an important determinant of disease progression. In order to delineate host...
- 12From: PLoS Genetics. (Vol. 7, Issue 8) Peer-ReviewedMutations in the SOD1 and TARDBP genes have been commonly identified in Amyotrophic Lateral Sclerosis (ALS). Recently, mutations in the Fused in sarcoma gene (FUS) were identified in familial (FALS) ALS cases and...
- 13From: PLoS Genetics. (Vol. 7, Issue 8) Peer-ReviewedThe identity of the specific molecules required for the process of retinal circuitry formation is largely unknown. Here we report a newly identified zebrafish mutant in which the absence of the atypical cadherin,...
- 14From: PLoS Genetics. (Vol. 7, Issue 8) Peer-ReviewedProtein phosphatase 2A (PP2A) plays a major role in dephosphorylating the targets of the major mitotic kinase Cdk1 at mitotic exit, yet how it is regulated in mitotic progression is poorly understood. Here we show that...
- 15From: PLoS Genetics. (Vol. 7, Issue 8) Peer-ReviewedOur aim was to identify genes that influence the inverse association of coffee with the risk of developing Parkinson's disease (PD). We used genome-wide genotype data and lifetime caffeinated-coffee-consumption data on...
- 16From: PLoS Genetics. (Vol. 7, Issue 8) Peer-ReviewedT-box proteins are conserved transcription factors that play crucial roles in development of all metazoans;and, in humans, mutations affecting T-box genes are associated with a variety of congenital diseases and...
- 17From: PLoS Genetics. (Vol. 7, Issue 8) Peer-Reviewed
Distinct Cdkl requirements during single-strand annealing, noncrossover, and crossover recombination
Repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) in haploid cells is generally restricted to S/ G2 cell cycle phases, when DNA has been replicated and a sister chromatid is available as a... - 18From: PLoS Genetics. (Vol. 7, Issue 8) Peer-ReviewedGenome-wide association (GWA) studies have identified numerous, replicable, genetic associations between common single nucleotide polymorphisms (SNPs) and risk of common autoimmune and inflammatory (immune-mediated)...
- 19From: PLoS Genetics. (Vol. 7, Issue 8) Peer-ReviewedAs organisms adaptively evolve to a new environment, selection results in the improvement of certain traits, bringing about an increase in fitness. Trade-offs may result from this process if function in other traits is...
- 20From: PLoS Genetics. (Vol. 7, Issue 8) Peer-ReviewedDuring early meiotic prophase, a nucleus-wide reorganization leads to sorting of chromosomes into homologous pairs and to establishing associations between homologous chromosomes along their entire lengths. Here, we...