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- 1From: Nature Reviews Molecular Cell Biology. (Vol. 7, Issue 8) Peer-ReviewedAuthor(s): Nicholas R. Cozzarelli [1, 2]; Gregory J. Cost (corresponding author) [1]; Marcelo Nöllmann [1]; Thierry Viard [1]; James E. Stray [1] The information content in a given length of DNA is limited by the...
- 2From: Nature Reviews Molecular Cell Biology. (Vol. 7, Issue 8) Peer-ReviewedAuthor(s): Robert B. Abramovitch [1]; Jeffrey C. Anderson [1]; Gregory B. Martin (corresponding author) [1, 2] Plants are a rich source of nutrients and water for microbes, and they are infected by many bacterial...
- 3From: Nature Reviews Molecular Cell Biology. (Vol. 7, Issue 8) Peer-ReviewedAuthor(s): James A. Goodrich [1]; Jennifer F. Kugel [1] A new paradigm has emerged in biology in which RNA molecules are active participants in regulating, catalysing and controlling many reactions that define...
- 4From: Nature Reviews Molecular Cell Biology. (Vol. 7, Issue 8) Peer-ReviewedAuthor(s): Ekat Kritikou More than 50 years ago, Otto Warburg showed that cancer cells downregulate their aerobic respiratory activity and preferentially use glycolytic pathways to generate energy. But how does this...
- 5From: Nature Reviews Molecular Cell Biology. (Vol. 7, Issue 8) Peer-ReviewedAuthor(s): Joerg Heineke [1]; Jeffery D. Molkentin (corresponding author) [1] Cardiovascular disease remains the number one cause of mortality in the Western world, with heart failure representing the fastest growing...
- 6From: Nature Reviews Molecular Cell Biology. (Vol. 7, Issue 8) Peer-ReviewedAuthor(s): Juan S. Bonifacino (corresponding author) [1]; Raul Rojas (corresponding author) [1] The secretory system of eukaryotic cells is organized as a series of membrane-enclosed compartments that include the...
- 7From: Nature Reviews Molecular Cell Biology. (Vol. 7, Issue 8) Peer-ReviewedAuthor(s): Shannon Amoils Although mouse embryonic stem (ES) cells were first isolated 25 years ago, many important questions about these remarkable cells remain unanswered. For instance, it's well known that ES cells...
- 8From: Nature Reviews Molecular Cell Biology. (Vol. 7, Issue 8) Peer-ReviewedAuthor(s): Arianne Heinrichs Recent studies have indicated that microRNAs (miRNAs) can reduce the levels of their target transcripts and the expression of the translated proteins. Elisa Izaurralde and colleagues now...
- 9From: Nature Reviews Molecular Cell Biology. (Vol. 7, Issue 8) Peer-ReviewedHundreds of protein factors participate in transcription and its regulation in eukaryotes. Many of these proteins regulate specific genes by targeting upstream promoter regions, whereas a smaller but mechanistically...
- 10From: Nature Reviews Molecular Cell Biology. (Vol. 7, Issue 8) Peer-ReviewedAuthor(s): Alison Rowan [1] Neurotransmitter release is well known to depend on calcium-triggered exocytosis of synaptic vesicles. But what is the mechanism that couples synaptic vesicle fusion and calcium? Giraudo...
- 11From: Nature Reviews Molecular Cell Biology. (Vol. 7, Issue 8) Peer-ReviewedAuthor(s): Arianne Heinrichs The regulation of mRNA nuclear export is crucial for accurate gene expression in eukaryotes and requires the remodelling of mRNAs into ribonucleoprotein complexes (mRNPs). The DEAD-box...
- 12From: Nature Reviews Molecular Cell Biology. (Vol. 7, Issue 8) Peer-ReviewedAuthor(s): Rachel Smallridge In Nature , Dogterom and colleagues now describe a new optical-tweezers- based method that can be used to observe the assembly dynamics of individual microtubules at molecular resolution....
- 13From: Nature Reviews Molecular Cell Biology. (Vol. 7, Issue 8) Peer-ReviewedOver the past 5 years, protein-chip technology has emerged as a useful tool for the study of many kinds of protein interactions and biochemical activities. The construction of Saccharomyces cerevisiae whole-proteome...
- 14From: Nature Reviews Molecular Cell Biology. (Vol. 7, Issue 8) Peer-ReviewedAuthor(s): Asher Mullard * http://www.natureprotocols.com/ We've all spent frustrating hours searching through the methods sections of articles to find the best way to do our experiments. And we've leafed through...
- 15From: Nature Reviews Molecular Cell Biology. (Vol. 7, Issue 8) Peer-ReviewedDNA replication Live-cell imaging reveals replication of individual replicons in eukaryotic replication factories . Kitamura, E. et al . Cell 125, 1297-1308 (2006) The authors developed a new assay to study the...
- 16From: Nature Reviews Molecular Cell Biology. (Vol. 7, Issue 8) Peer-ReviewedAuthor(s): Asher Mullard Epidermal growth factor (EGF) causes its receptor, EGFR, to dimerize and -- through a previously unknown mechanism -- become activated to effect downstream signalling, cell growth,...
- 17From: Nature Reviews Molecular Cell Biology. (Vol. 7, Issue 8) Peer-ReviewedAuthor(s): Ekat Kritikou The function of VAV proteins has been extensively characterized downstream of immune-response receptors. Now, the role of VAV proteins is expanding, as two reports show that these proteins...
- 18From: Nature Reviews Molecular Cell Biology. (Vol. 7, Issue 8) Peer-ReviewedAuthor(s): Rachel Smallridge The arginylation of [beta]-actin regulates the actin cytoskeleton and cell motility, report Kashina and colleagues in Science . The post-translational addition of an Arg residue to the N...
- 19From: Nature Reviews Molecular Cell Biology. (Vol. 7, Issue 8) Peer-ReviewedDetecting dynamics A new live-cell-imaging approach that gives insights into the dynamic nature of protein-interaction networks in intact cell nuclei is now described by Day and colleagues in Nature Methods . This...
- 20From: Nature Reviews Molecular Cell Biology. (Vol. 7, Issue 8) Peer-ReviewedCardiovascular diseases remain the number one cause of mortality in the Western world, with heart failure representing the fastest growing subclass over the past decade. In this month's article for the Series on...