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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 7AndIssue Number: 7AndStart Page: e1002179AndDate: 2011 Revise Search
- 1From: PLoS Genetics. (Vol. 7, Issue 7) Peer-ReviewedNon-additive interactions between genomes have important implications, not only for practical applications such as breeding, but also for understanding evolution. In extreme cases, genes from different genomic...
- 2From: PLoS Genetics. (Vol. 7, Issue 7) Peer-ReviewedLong-chain n-3 polyunsaturated fatty acids (PUFAs) can derive from diet or from a-linolenic acid (ALA) by elongation and desaturation. We investigated the association of common genetic variation with plasma phospholipid...
- 3From: PLoS Genetics. (Vol. 7, Issue 7) Peer-ReviewedThe aim of this study was to determine, through a genome-wide association study (GWAS), the genetic components contributing to different clinical sub-phenotypes of systemic sclerosis (SSc). We considered limited (lcSSc)...
- 4From: PLoS Genetics. (Vol. 7, Issue 7) Peer-ReviewedThe mammalian Cdkn2a (Ink4a-Arf) locus encodes two tumor suppressor proteins ([p16.sup.Ink4a] and [p19.sup.Arf]) that respectively enforce the anti-proliferative functions of the retinoblastoma protein (Rb) and the p53...
- 5From: PLoS Genetics. (Vol. 7, Issue 7) Peer-ReviewedType VI secretion systems (T6SS) are macromolecular machines of the cell envelope of Gram-negative bacteria responsible for bacterial killing and/or virulence towards different host cells. Here, we characterized the...
- 6From: PLoS Genetics. (Vol. 7, Issue 7) Peer-ReviewedHorizontally acquired genes typically function as autonomous units conferring new abilities when introduced into different species. However, we reasoned that proteins preexisting in an organism might constrain the...
- 7From: PLoS Genetics. (Vol. 7, Issue 7) Peer-ReviewedGenomic maps of chromatin modifications have provided evidence for the partitioning of genomes into domains of distinct chromatin states, which assist coordinated gene regulation. The maintenance of chromatin domain...
- 8From: PLoS Genetics. (Vol. 7, Issue 7) Peer-ReviewedIn humans, sexual dimorphism is associated with the presence of two X chromosomes in the female, whereas males possess only one X and a small and largely degenerate Y chromosome. How do men cope with having only a...
- 9From: PLoS Genetics. (Vol. 7, Issue 7) Peer-ReviewedThe whole-genome duplication (WGD) that occurred during yeast evolution changed the basal number of chromosomes from 8 to 16. However, the number of chromosomes in post-WGD species now ranges between 10 and 16, and the...
- 10From: PLoS Genetics. (Vol. 7, Issue 7) Peer-ReviewedSystemic sclerosis (SSc) is an orphan, complex, inflammatory disease affecting the immune system and connective tissue. SSc stands out as a severely incapacitating and life-threatening inflammatory rheumatic disease,...
- 11From: PLoS Genetics. (Vol. 7, Issue 7) Peer-ReviewedGenome-wide association studies (GWAS) are now used routinely to identify SNPs associated with complex human phenotypes. In several cases, multiple variants within a gene contribute independently to disease risk. Here...
- 12From: PLoS Genetics. (Vol. 7, Issue 7) Peer-ReviewedGlucocorticoids (GCs) mediate physiological responses to environmental stress and are commonly used as pharmaceuticals. GCs act primarily through the GC receptor (GR, a transcription factor). Despite their clear...
- 13From: PLoS Genetics. (Vol. 7, Issue 7) Peer-ReviewedStem cell dynamics in vivo are often being studied by lineage tracing methods. Our laboratory has previously developed a retrospective method for reconstructing cell lineage trees from somatic mutations accumulated in...
- 14From: PLoS Genetics. (Vol. 7, Issue 7) Peer-ReviewedDNA methylation is an evolutionarily conserved epigenetic modification that is critical for gene silencing and the maintenance of genome integrity. In Arabidopsis thaliana, the de novo DNA methyltransferase, DOMAINS...
- 15From: PLoS Genetics. (Vol. 7, Issue 7) Peer-Reviewed
Replication and explorations of high-order epistasis using a large advanced intercross line pedigree
Dissection of the genetic architecture of complex traits persists as a major challenge in biology;despite considerable efforts, much remains unclear including the role and importance of genetic interactions. This study... - 16From: PLoS Genetics. (Vol. 7, Issue 7) Peer-ReviewedWith recent advances in genomic technologies, candidate human disease genes are being mapped at an accelerated pace. There is a clear need to move forward with genetic tools that can efficiently validate these mutations...
- 17From: PLoS Genetics. (Vol. 7, Issue 7) Peer-ReviewedCircadian-regulated gene expression is predominantly controlled by a transcriptional negative feedback loop, and it is evident that chromatin modifications and chromatin remodeling are integral to this process in...
- 18From: PLoS Genetics. (Vol. 7, Issue 7) Peer-ReviewedPhotosynthesis is the final determinator for crop yield. To gain insight into genes controlling photosynthetic capacity, we selected from our large T-DNA mutant population a rice stunted growth mutant with decreased...
- 19From: PLoS Genetics. (Vol. 7, Issue 7) Peer-ReviewedThe phytohormone abscisic acid (ABA) is an important regulator of plant development and response to environmental stresses. In this study, we identified two ABA overly sensitive mutant alleles in a gene encoding Auxin...
- 20From: PLoS Genetics. (Vol. 7, Issue 7) Peer-ReviewedForkhead-box protein P2 is a transcription factor that has been associated with intriguing aspects of cognitive function in humans, non-human mammals, and song-learning birds. Heterozygous mutations of the human FOXP2...