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- 1From: PLoS Pathogens. (Vol. 7, Issue 7) Peer-ReviewedBorrelia burgdorferi, the spirochetal agent of Lyme disease, is a vector-borne pathogen that cycles between a mammalian host and tick vector. This complex life cycle requires that the spirochete modulate its gene...
- 2From: PLoS Pathogens. (Vol. 7, Issue 7) Peer-ReviewedCutaneous beta human papillomavirus (HPV) types appear to be involved in the development of non-melanoma skin cancer (NMSC);however, it is not entirely clear whether they play a direct role. We have previously shown...
- 3From: PLoS Pathogens. (Vol. 7, Issue 7) Peer-ReviewedPathogens have evolved sophisticated mechanisms to evade detection and destruction by the host immune system. Large DNA viruses encode homologues of chemokines and their receptors, as well as chemokine-binding proteins...
- 4From: PLoS Pathogens. (Vol. 7, Issue 7) Peer-ReviewedClosely related pathogens may differ dramatically in host range, but the molecular, genetic, and evolutionary basis for these differences remains unclear. In many Gram- negative bacteria, including the phytopathogen...
- 5From: PLoS Pathogens. (Vol. 7, Issue 7) Peer-ReviewedRhinovirus infections are the major cause of asthma exacerbations. We hypothesised that IL-15, a cytokine implicated in innate and acquired antiviral immunity, may be deficient in asthma and important in the...
- 6From: PLoS Pathogens. (Vol. 7, Issue 7) Peer-ReviewedStudies of the 1918 H1N1 influenza pandemic, the H5N1 avian influenza outbreak, and the 2009 H1N1 pandemic illustrate that sex and pregnancy contribute to severe outcome from infection, suggesting a role for sex...
- 7From: PLoS Pathogens. (Vol. 7, Issue 7) Peer-ReviewedThe vascular wilt fungi Verticillium dahliae and V. albo-atrum infect over 200 plant species, causing billions of dollars in annual crop losses. The characteristic wilt symptoms are a result of colonization and...
- 8From: PLoS Pathogens. (Vol. 7, Issue 7) Peer-ReviewedEffective population size (Ne) determines the strength of genetic drift and the frequency of co-infection by multiple genotypes, making it a key factor in viral evolution. Experimental estimates of Ne for different...
- 9From: PLoS Pathogens. (Vol. 7, Issue 7) Peer-ReviewedMycobacterium tuberculosis (Mtb) has evolved into a highly successful human pathogen. It deftly subverts the bactericidal mechanisms of alveolar macrophages, ultimately inducing granuloma formation and establishing...
- 10From: PLoS Pathogens. (Vol. 7, Issue 7) Peer-ReviewedViruses rely on the metabolic network of the host cell to provide energy and macromolecular precursors to fuel viral replication. Here we used mass spectrometry to examine the impact of two related herpesviruses, human...
- 11From: PLoS Pathogens. (Vol. 7, Issue 7) Peer-ReviewedRANTES (CCL5) is a chemokine expressed by many hematopoietic and non-hematopoietic cell types that plays an important role in homing and migration of effector and memory T cells during acute infections. The RANTES...
- 12From: PLoS Pathogens. (Vol. 7, Issue 7) Peer-ReviewedChlamydia trachomatis is an obligate intracellular bacterium that alternates between two metabolically different developmental forms. We performed fluorescence lifetime imaging (FLiM) of the metabolic coenzymes, reduced...
- 13From: PLoS Pathogens. (Vol. 7, Issue 7) Peer-ReviewedThe hTREX complex mediates cellular bulk mRNA nuclear export by recruiting the nuclear export factor, TAP, via a direct interaction with the export adaptor, Aly. Intriguingly however, depletion of Aly only leads to a...
- 14From: PLoS Pathogens. (Vol. 7, Issue 7) Peer-ReviewedSmall RNAs (sRNAs) are becoming increasingly recognized as important regulators in bacteria. To investigate the contribution of sRNA mediated regulation to virulence in Vibrio cholerae, we performed high throughput...
- 15From: PLoS Pathogens. (Vol. 7, Issue 7) Peer-ReviewedHepatitis C virus (HCV) assembly remains a poorly understood process. Lipid droplets (LDs) are thought to act as platforms for the assembly of viral components. The JFH1 HCV strain replicates and assembles in...
- 16From: PLoS Pathogens. (Vol. 7, Issue 7) Peer-ReviewedNoroviruses, an important cause of acute gastroenteritis in humans, recognize the histo-blood group antigens (HBGAs) as host susceptible factors in a strain-specific manner. The crystal structures of the HBGA-binding...
- 17From: PLoS Pathogens. (Vol. 7, Issue 7) Peer-ReviewedAlthough an existential threat from the microbial world might seem like science fiction, a catastrophic decline in amphibian populations with the extinction of dozens of species has been attributed to a chytrid fungus...
- 18From: PLoS Pathogens. (Vol. 7, Issue 7) Peer-ReviewedThe Mycobacterium tuberculosis Ser/Thr kinase PknB has been implicated in the regulation of cell growth and morphology in this organism. The extracytoplasmic domain of this membrane protein comprises four penicillin...
- 19From: PLoS Pathogens. (Vol. 7, Issue 7) Peer-ReviewedIntroduction Rather than being slowly eroded and destroyed, countless numbers of varied forms of life adapt to the diverse aspects of an ever changing environment. However, the amount of variation is maintained at a...
- 20From: PLoS Pathogens. (Vol. 7, Issue 7) Peer-ReviewedThe inhibitory receptor programmed death-1 (PD-1) has the capacity to maintain peripheral tolerance and limit immunopathological damage; however, its precise role in fulminant viral hepatitis (FH) has yet to be...