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- Search Terms:ISSN: 1553734XAndISSN: 15537358AndVolume Number: 7AndIssue Number: 7AndStart Page: e1002119AndDate: 2011 Revise Search
- 1From: PLoS Computational Biology. (Vol. 7, Issue 7) Peer-ReviewedIndirect reciprocity, in which individuals help others with a good reputation but not those with a bad reputation, is a mechanism for cooperation in social dilemma situations when individuals do not repeatedly interact...
- 2From: PLoS Computational Biology. (Vol. 7, Issue 7) Peer-ReviewedAn important problem in neuronal computation is to discern how features of stimuli control the timing of action potentials. One aspect of this problem is to determine how an action potential, or spike, can be elicited...
- 3From: PLoS Computational Biology. (Vol. 7, Issue 7) Peer-ReviewedPrevious studies have shown that neurons within the vestibular nuclei (VN) can faithfully encode the time course of sensory input through changes in firing rate in vivo. However, studies performed in vitro have shown...
- 4From: PLoS Computational Biology. (Vol. 7, Issue 7) Peer-ReviewedDynamic properties are functionally important in many proteins, including the enzyme adenylate kinase (AK), for which the open/closed transition limits the rate of catalytic turnover. Here, we compare our previously...
- 5From: PLoS Computational Biology. (Vol. 7, Issue 7) Peer-ReviewedWe use a novel normal mode analysis of an elastic network model drawn from configurations generated during microsecond all-atom molecular dynamics simulations to analyze the mechanism of auto-inhibition of AMP-activated...
- 6From: PLoS Computational Biology. (Vol. 7, Issue 7) Peer-ReviewedAlthough many of the core components of the embryonic cell-cycle network have been elucidated, the question of how embryos achieve robust, synchronous cellular divisions post-fertilization remains unexplored. What are...
- 7From: PLoS Computational Biology. (Vol. 7, Issue 7) Peer-ReviewedThere is a body of literature that describes the geometry and the physics of filopodia using either stochastic models or partial differential equations and elasticity and coarse-grained theory. Comparatively, there is a...
- 8From: PLoS Computational Biology. (Vol. 7, Issue 7) Peer-ReviewedChromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) is rapidly replacing chromatin immunoprecipitation combined with genome-wide tiling array analysis (ChIP-chip) as the preferred approach...
- 9From: PLoS Computational Biology. (Vol. 7, Issue 7) Peer-ReviewedThe breast cancer suppressor BRCA2 controls the recombinase RAD51 in the reactions that mediate homologous DNA recombination, an essential cellular process required for the error-free repair of DNA double-stranded...
- 10From: PLoS Computational Biology. (Vol. 7, Issue 7) Peer-ReviewedThe flexibility in the structure of calmodulin (CaM) allows its binding to over 300 target proteins in the cell. To investigate the structure-function relationship of CaM, we combined methods of computer simulation and...
- 11From: PLoS Computational Biology. (Vol. 7, Issue 7) Peer-ReviewedThe question whether fatty acids can be converted into glucose in humans has a long standing tradition in biochemistry, and the expected answer is "No". Using recent advances in Systems Biology in the form of...
- 12From: PLoS Computational Biology. (Vol. 7, Issue 7) Peer-ReviewedThe thick-tufted layer 5b pyramidal cell extends its dendritic tree to all six layers of the mammalian neocortex and serves as a major building block for the cortical column. L5b pyramidal cells have been the subject of...
- 13From: PLoS Computational Biology. (Vol. 7, Issue 7) Peer-ReviewedAdvances in reporters for gene expression have made it possible to document and quantify expression patterns in 2D-4D. in contrast to microarrays, which provide data for many genes but averaged and/or at low resolution,...
- 14From: PLoS Computational Biology. (Vol. 7, Issue 7) Peer-ReviewedVector-borne diseases are emerging and re-emerging in urban environments throughout the world, presenting an increasing challenge to human health and a major obstacle to development. Currently, more than half of the...
- 15From: PLoS Computational Biology. (Vol. 7, Issue 7) Peer-ReviewedThe reciprocal differentiation of T helper 17 ([T.sub.H]17) cells and induced regulatory T ([iT.sub.reg]) cells plays a critical role in both the pathogenesis and resolution of diverse human inflammatory diseases....
- 16From: PLoS Computational Biology. (Vol. 7, Issue 7) Peer-ReviewedOver the last decade, and especially after the advent of fluorescent in situ hybridization imaging and chromosome conformation capture methods, the availability of experimental data on genome three-dimensional...
- 17From: PLoS Computational Biology. (Vol. 7, Issue 7) Peer-ReviewedRealistic, individual-based models based on detailed census data are increasingly used to study disease transmission. Whether the rich structure of such models improves predictions is debated. This is studied here for...
- 18From: PLoS Computational Biology. (Vol. 7, Issue 7) Peer-ReviewedAdvances in proteomic technologies continue to substantially accelerate capability for generating experimental data on protein levels, states, and activities in biological samples. For example, studies on receptor...
- 19From: PLoS Computational Biology. (Vol. 7, Issue 7) Peer-ReviewedCell penetrating peptides (CPPs) are those peptides that can transverse cell membranes to enter cells. Once inside the cell, different CPPs can localize to different cellular components and perform different roles. Some...
- 20From: PLoS Computational Biology. (Vol. 7, Issue 7) Peer-ReviewedCo-localization of networks of genes in the nucleus is thought to play an important role in determining gene expression patterns. Based upon experimental data, we built a dynamical model to test whether pure diffusion...