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- 1From: Nature Methods. (Vol. 7, Issue 7) Peer-ReviewedThe misfolded form of the prion protein, PrP.sup.Sc, can be quantified in a variety of tissues and fluids using a quantitative version of the popular protein misfolding cyclic amplification (PMCA) assay. Prions, the...
- 2From: Nature Methods. (Vol. 7, Issue 7) Peer-ReviewedAs proteome-wide C-terminal sequence analysis has been largely intractable, we developed a polymer-based enrichment approach to profile protein C-terminal peptides by mass spectrometry and identified hundreds of...
- 3From: Nature Methods. (Vol. 7, Issue 7) Peer-ReviewedRaw data of millions of sequences used to assemble the reference genomes of ten organisms are analyzed in search of mismatches indicative of editing events. Findings include candidate sites for in vivo DNA and RNA...
- 4From: Nature Methods. (Vol. 7, Issue 7) Peer-ReviewedTo the Editor: Structural variants constitute the largest portion of nucleotide variation in genomes, yet their comprehensive characterization based on high-throughput sequencing technologies is still challenging (1)....
- 5From: Nature Methods. (Vol. 7, Issue 7) Peer-ReviewedRecent studies using high-throughput sequencing protocols have uncovered the complexity of mammalian transcription by RNA polymerase II, helping to define several initiation patterns in which transcription start sites...
- 6From: Nature Methods. (Vol. 7, Issue 7) Peer-ReviewedResearchers synthesized the first functional synthetic bacterial genome; repeating this feat with different bacteria will require further methodological development. Recently, scientists from the J. Craig Venter...
- 7From: Nature Methods. (Vol. 7, Issue 7) Peer-ReviewedLive-cell time-lapse imaging of somatic cells undergoing reprogramming raises interesting questions about the mechanism of the process. One of the problems that continues to both bedevil and tantalize those studying...
- 8From: Nature Methods. (Vol. 7, Issue 7) Peer-ReviewedAlthough genome-wide association studies have uncovered single-nucleotide polymorphisms (SNPs) associated with complex disease, these variants account for a small portion of heritability. Some contribution to this...
- 9From: Nature Methods. (Vol. 7, Issue 7) Peer-ReviewedWe describe a positional proteomics approach to simultaneously analyze N- and C-terminal peptides and used it to screen for human protein substrates of granzyme B and carboxypeptidase A4 in human cell lysates. This...
- 10From: Nature Methods. (Vol. 7, Issue 7) Peer-ReviewedWith a combination of microscopic and computational methods, the lineage of cells produced by divisions in the meristems of growing plants can now be tracked over time. Plant growth is a fine example of how a system...
- 11From: Nature Methods. (Vol. 7, Issue 7) Peer-ReviewedThe enzyme-linked immunosorbent assay, ELISA, is not sensitive enough to detect proteins found in very low concentrations in biological samples. Rissin et al. describe a 'digital ELISA', which can be used to detect...
- 12From: Nature Methods. (Vol. 7, Issue 7) Peer-ReviewedLarge-scale sequencing projects have revealed an unexpected complexity in the origins, structures and functions of mammalian transcripts. Many loci are known to produce overlapping coding and noncoding RNAs with capped...
- 13From: Nature Methods. (Vol. 7, Issue 7) Peer-ReviewedDamage to mechanosensitive sensory hair cells found in the mammalian inner ear can result in permanent hearing loss and balance problems because these cells do not regenerate. Oshima et al. report a protocol to generate...
- 14From: Nature Methods. (Vol. 7, Issue 7) Peer-ReviewedSometimes an aerospace engineer feels compelled to watch fruit flies walk on tiny foam balls. Actually, Vivek Jayaraman is not the only one watching. In his laboratory at Janelia Farms, researchers have manipulated both...
- 15From: Nature Methods. (Vol. 7, Issue 7) Peer-ReviewedSimplified methods to map transcription start sites allow the exploration of transcription-initiation landscapes in rare cell types. The initiation of transcription by RNA polymerase II is a defining event in...
- 16From: Nature Methods. (Vol. 7, Issue 7) Peer-ReviewedWe expressed SID-1, a transmembrane protein from Caenorhabditis elegans that is required for systemic R interference (RNAi), in C. elegans neurons. This expression increased the response of neurons to double-stranded...
- 17From: Nature Methods. (Vol. 7, Issue 7) Peer-ReviewedGeert Hamer, Olli Matilainen & Carina I Holmberg Nat. Methods 7, 473-478 (2010); published online 9 May 2010; corrected after print 17 June 2010. In the version of this paper originally published, a reference to...
- 18From: Nature Methods. (Vol. 7, Issue 7) Peer-ReviewedA technique combining laser and electron pulses is used to achieve nanometer and femtosecond resolution in biological imaging. Researchers who hope to see fine cell details often must resort to techniques that...
- 19From: Nature Methods. (Vol. 7, Issue 7) Peer-ReviewedTo the Editor: In their correspondence in Nature Methods, Adler et al. claim to present the first high-resolution topography of plasma membranes in living cells (1). Using hopping-probe ion conductance microscopy...
- 20From: Nature Methods. (Vol. 7, Issue 7) Peer-ReviewedIn their struggle to help data processing keep up with data production, members of genomics laboratories are venturing into cloud computing (p. 495). First launched commercially about four years ago by Amazon, cloud...