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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 7AndIssue Number: 5AndStart Page: e1002083AndDate: 2011 Revise Search
- 1From: PLoS Genetics. (Vol. 7, Issue 5) Peer-ReviewedDRM is a conserved transcription factor complex that includes E2F/DP and pRB family proteins and plays important roles in development and cancer. Here we describe new aspects of DRM binding and function revealed through...
- 2From: PLoS Genetics. (Vol. 7, Issue 5) Peer-ReviewedAccurate segregation of homologous chromosomes of different parental origin (homologs) during the first division of meiosis (meiosis I) requires inter-homolog crossovers (COs). These are produced at the end of meiosis I...
- 3From: PLoS Genetics. (Vol. 7, Issue 5) Peer-ReviewedElevation of the second messenger cGMP by nitric oxide (NO) activates the cGMP-dependent protein kinase PKG, which is key in regulating cardiovascular, intestinal, and neuronal functions in mammals. The NO-cGMP-PKG...
- 4From: PLoS Genetics. (Vol. 7, Issue 5) Peer-ReviewedNeural signals are processed in nervous systems of animals responding to variable environmental stimuli. This study shows that a novel and highly conserved protein, macoilin (MACO-1), plays an essential role in diverse...
- 5From: PLoS Genetics. (Vol. 7, Issue 5) Peer-ReviewedThe discovery of expression quantitative trait loci ("eQTLs") can help to unravel genetic contributions to complex traits. We identified genetic determinants of human liver gene expression variation using two...
- 6From: PLoS Genetics. (Vol. 7, Issue 5) Peer-ReviewedThe Saccharomyces cerevisiae Dunl protein kinase is a downstream target of the conserved Mec1-Rad53 checkpoint pathway. Dun1 regulates dNTP pools during an unperturbed cell cycle and after DNA damage by modulating the...
- 7From: PLoS Genetics. (Vol. 7, Issue 5) Peer-ReviewedTy elements are high copy number, dispersed repeated sequences in the Saccharomyces cerevisiae genome known to mediate gross chromosomal rearrangements (GCRs). Here we found that introduction of Ty912, a previously...
- 8From: PLoS Genetics. (Vol. 7, Issue 5) Peer-ReviewedVertebrate mesendoderm specification requires the Nodal signaling pathway and its transcriptional effector FoxH1. However, loss of FoxH1 in several species does not reliably cause the full range of loss-of-Nodal...
- 9From: PLoS Genetics. (Vol. 7, Issue 5) Peer-ReviewedSusan Lindquist and I had been trying to intersect for an interview for about 5 years. Lindquist (Image 1), who is currently on the faculty at MIT's Whitehead Institute, is well-known for her work on protein chaperones...
- 10From: PLoS Genetics. (Vol. 7, Issue 5) Peer-ReviewedMicroRNAs (miRNAs) post-transcriptionally regulate the expression of thousands of distinct mRNAs. While some regulatory interactions help to maintain basal cellular functions, others are likely relevant in more specific...
- 11From: PLoS Genetics. (Vol. 7, Issue 5) Peer-ReviewedLong non-coding RNAs regulate various biological processes such as dosage compensation, imprinting, and chromatin organization. HOTAIR, a paradigm of this new class of RNAs, is localized within the human HOXC gene...
- 12From: PLoS Genetics. (Vol. 7, Issue 5) Peer-ReviewedGWAS of prostate cancer have been remarkably successful in revealing common genetic variants and novel biological pathways that are linked with its etiology. A more complete understanding of inherited susceptibility to...
- 13From: PLoS Genetics. (Vol. 7, Issue 5) Peer-ReviewedEpigenetic reprogramming is a critical event in the generation of induced pluripotent stem cells (iPSCs). Here, we determined the DNA methylation profiles of 22 human iPSC lines derived from five different cell types...
- 14From: PLoS Genetics. (Vol. 7, Issue 5) Peer-ReviewedChinese Erhualian is the most prolific pig breed in the world. The breed exhibits exceptionally large and floppy ears. To identify genes underlying this typical feature, we previously performed a genome scan in a large...
- 15From: PLoS Genetics. (Vol. 7, Issue 5) Peer-ReviewedThe synaptonemal complex (SC) is a proteinaceous, meiosis-specific structure that is highly conserved in evolution. During meiosis, the SC mediates synapsis of homologous chromosomes. It is essential for proper...
- 16From: PLoS Genetics. (Vol. 7, Issue 5) Peer-ReviewedSystemic lupus erythematosus (SLE), a complex polygenic autoimmune disease, is associated with increased complement activation. Variants of genes encoding complement regulator factor H (CFH) and five CFH-related...
- 17From: PLoS Genetics. (Vol. 7, Issue 5) Peer-ReviewedMuscle-eye-brain disease (MEB) and Walker Warburg Syndrome (WWS) belong to a spectrum of autosomal recessive diseases characterized by ocular dysgenesis, neuronal migration defects, and congenital muscular dystrophy....
- 18From: PLoS Genetics. (Vol. 7, Issue 5) Peer-ReviewedThe current excitement about adult stem and progenitor cells is an opportunity for developmental biologists to shed new light on old problems. Where do differentiated cells in the adult come from, and what else can...
- 19From: PLoS Genetics. (Vol. 7, Issue 5) Peer-ReviewedSphingolipids, lipids with a common sphingoid base (also termed long chain base) backbone, play essential cellular structural and signaling functions. Alterations of sphingolipid levels have been implicated in many...
- 20From: PLoS Genetics. (Vol. 7, Issue 5) Peer-ReviewedThe molecular mechanisms of plant recognition, colonization, and nutrient exchange between diazotrophic endophytes and plants are scarcely known. Herbaspirillum seropedicae is an endophytic bacterium capable of...