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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 7AndIssue Number: 4AndStart Page: e1001366AndDate: 2011 Revise Search
- 1From: PLoS Genetics. (Vol. 7, Issue 4) Peer-ReviewedHumans inhabit a remarkably diverse range of environments, and adaptation through natural selection has likely played a central role in the capacity to survive and thrive in extreme climates. Unlike numerous studies that...
- 2From: PLoS Genetics. (Vol. 7, Issue 4) Peer-ReviewedApproximately 80% of human breast carcinomas present as oestrogen receptor a-positive (ER+ve) disease, and ER status is a critical factor in treatment decision-making. Recently, single nucleotide polymorphisms (SNPs) in...
- 3From: PLoS Genetics. (Vol. 7, Issue 4) Peer-ReviewedThe morphogenetic transition between yeast and filamentous forms of the human fungal pathogen Candida albicans is regulated by a variety of signaling pathways. How these pathways interact to orchestrate morphogenesis,...
- 4From: PLoS Genetics. (Vol. 7, Issue 4) Peer-ReviewedSoluble ICAM-1 (sICAM-1) is an endothelium-derived inflammatory marker that has been associated with diverse conditions such as myocardial infarction, diabetes, stroke, and malaria. Despite evidence for a heritable...
- 5From: PLoS Genetics. (Vol. 7, Issue 4) Peer-ReviewedAutosomal dominant polycystic kidney disease (ADPKD) is characterized by formation of renal cysts that destroy the kidney. Mutations in PKD1 and PKD2, encoding polycystins-1 and -2, cause ADPKD. Polycystins are thought...
- 6From: PLoS Genetics. (Vol. 7, Issue 4) Peer-ReviewedAlbeit genetically highly heterogeneous, muscular dystrophies (MDs) share a convergent pathology leading to muscle wasting accompanied by proliferation of fibrous and fatty tissue, suggesting a common...
- 7From: PLoS Genetics. (Vol. 7, Issue 4) Peer-ReviewedMetachondromatosis (MC) is a rare, autosomal dominant, incompletely penetrant combined exostosis and enchondromatosis tumor syndrome. MC is clinically distinct from other multiple exostosis or multiple enchondromatosis...
- 8From: PLoS Genetics. (Vol. 7, Issue 4) Peer-ReviewedWhile genome-wide association studies (GWAS) have primarily examined populations of European ancestry, more recent studies often involve additional populations, including admixed populations such as African Americans...
- 9From: PLoS Genetics. (Vol. 7, Issue 4) Peer-ReviewedHeterochromatin silencing is pivotal for genome stability in eukaryotes. In Arabidopsis, a plant-specific mechanism called RNA-directed DNA methylation (RdDM) is involved in heterochromatin silencing. Histone...
- 10From: PLoS Genetics. (Vol. 7, Issue 4) Peer-ReviewedSignificant advances have been made in the discovery of genes affecting bone mineral density (BMD);however, our understanding of its genetic basis remains incomplete. In the current study, genome-wide association (GWA)...
- 11From: PLoS Genetics. (Vol. 7, Issue 4) Peer-ReviewedTransient Receptor Potential (TRP) channels serve as temperature receptors in a wide variety of animals and must have played crucial roles in thermal adaptation. The TRP vanilloid (TRPV) subfamily contains several...
- 12From: PLoS Genetics. (Vol. 7, Issue 4) Peer-ReviewedPrevious genetic studies have suggested a history of sub-Saharan African gene flow into some West Eurasian populations after the initial dispersal out of Africa that occurred at least 45,000 years ago. However, there...
- 13From: PLoS Genetics. (Vol. 7, Issue 4) Peer-ReviewedEukaryotic cells have evolved to use complex pathways for DNA damage signaling and repair to maintain genomic integrity. RNF168 is a novel E3 ligase that functions downstream of ATM,[gamma]-H2A.X, MDC1, and RNF8. It has...
- 14From: PLoS Genetics. (Vol. 7, Issue 4) Peer-Reviewed
Incorporating biological pathways via a Markov random field model in genome-wide association studies
Genome-wide association studies (GWAS) examine a large number of markers across the genome to identify associations between genetic variants and disease. Most published studies examine only single markers, which may be... - 15From: PLoS Genetics. (Vol. 7, Issue 4) Peer-ReviewedChromosome instability (CIN) is observed in most solid tumors and is linked to somatic mutations in genome integrity maintenance genes. The spectrum of mutations that cause CIN is only partly known and it is not...
- 16From: PLoS Genetics. (Vol. 7, Issue 4) Peer-ReviewedMouse embryonic stem (ES) cells are defined by their capacity to self-renew and their ability to differentiate into all adult tissues including the germ line. Along with efficient clonal propagation, these properties...
- 17From: PLoS Genetics. (Vol. 7, Issue 4) Peer-ReviewedPlants rely heavily on receptor-like kinases (RLKs) for perception and integration of external and internal stimuli. The Arabidopsis regulatory leucine-rich repeat RLK (LRR-RLK) BAK1 is involved in steroid hormone...
- 18From: PLoS Genetics. (Vol. 7, Issue 4) Peer-ReviewedThe ribosomal rDNA gene array is an epigenetically-regulated repeated gene locus. While rDNA copy number varies widely between and within species, the functional consequences of subtle copy number polymorphisms have...
- 19From: PLoS Genetics. (Vol. 7, Issue 4) Peer-ReviewedRecent large genome-wide association studies (GWAS) have identified multiple loci which harbor genetic variants associated with type 2 diabetes mellitus (T2D), many of which encode proteins not previously suspected to...
- 20From: PLoS Genetics. (Vol. 7, Issue 4) Peer-ReviewedThe establishment of the germline is a critical, yet surprisingly evolutionarily labile, event in the development of sexually reproducing animals. In the fly Drosophila, germ cells acquire their fate early during...