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- Search Terms:ISSN: 15537366AndISSN: 15537374AndVolume Number: 7AndIssue Number: 4AndStart Page: e1001332AndDate: 2011 Revise Search
- 1From: PLoS Pathogens. (Vol. 7, Issue 4) Peer-ReviewedClostridium difficile is the main cause of antibiotic-associated diarrhea, leading to significant morbidity and mortality and putting considerable economic pressure on healthcare systems. Current knowledge of the...
- 2From: PLoS Pathogens. (Vol. 7, Issue 4) Peer-ReviewedNumerous constraints significantly hamper the experimental study of hepatitis C virus (HCV). Robust replication in cell culture occurs with only a few strains, and is invariably accompanied by adaptive mutations that...
- 3From: PLoS Pathogens. (Vol. 7, Issue 4) Peer-ReviewedFor many pathogens with environmental stages, or those carried by vectors or intermediate hosts, disease transmission is strongly influenced by pathogen, host, and vector movements across complex landscapes, and thus...
- 4From: PLoS Pathogens. (Vol. 7, Issue 4) Peer-ReviewedThe calcium-gated potassium channel SLO-1 in Caenorhabditis elegans was recently identified as key component for action of emodepside, a new anthelmintic drug with broad spectrum activity. In this study we identified...
- 5From: PLoS Pathogens. (Vol. 7, Issue 4) Peer-ReviewedHuman TRIM5[alpha] potently restricts particular strains of murine leukemia viruses (the so-called N-tropic strains) but not others (the B- or NB-tropic strains) during early stages of infection. We show that...
- 6From: PLoS Pathogens. (Vol. 7, Issue 4) Peer-ReviewedHepatitis C virus (HCV) is hepatotropic and only infects humans and chimpanzees. Consequently, an immunocompetent small animal model is lacking. The restricted tropism of HCV likely reflects specific host factor...
- 7From: PLoS Pathogens. (Vol. 7, Issue 4) Peer-ReviewedTransposon-mediated transformation was used to produce Anopheles stephensi that express single-chain antibodies (scFvs) designed to target the human malaria parasite, Plasmodium falciparum. The scFvs, m1C3, m4B7, and...
- 8From: PLoS Pathogens. (Vol. 7, Issue 4) Peer-ReviewedWe recently demonstrated that the respiratory syncytial virus (RSV) NS1 protein, an antagonist of host type I interferon (IFN-I) production and signaling, has a suppressive effect on the maturation of human dendritic...
- 9From: PLoS Pathogens. (Vol. 7, Issue 4) Peer-ReviewedPlasmodium knowlesi, a malaria parasite originally thought to be restricted to macaques in Southeast Asia, has recently been recognized as a significant cause of human malaria. Unlike the benign and morphologically...
- 10From: PLoS Pathogens. (Vol. 7, Issue 4) Peer-ReviewedActivation of I-[kappa]B kinases (IKKs) and NF-[kappa]B by the human T lymphotropic virus type 1 (HTLV-1) trans- activator/oncoprotein, Tax, is thought to promote cell proliferation and transformation. Paradoxically,...
- 11From: PLoS Pathogens. (Vol. 7, Issue 4) Peer-ReviewedThe evolution of drug resistant bacteria is a severe public health problem, both in hospitals and in the community. Currently, some countries aim at concentrating highly specialized services in large hospitals in order...
- 12From: PLoS Pathogens. (Vol. 7, Issue 4) Peer-ReviewedDuring plant-pathogen interactions, the plant may mount several types of defense responses to either block the pathogen completely or ameliorate the amount of disease. Such responses include release of reactive oxygen...
- 13From: PLoS Pathogens. (Vol. 7, Issue 4) Peer-ReviewedThe global burden of HIV-associated cryptococcal meningitis is estimated at nearly one million cases per year, causing up to a third of all AIDS-related deaths. Molecular epidemiology constitutes the main methodology...
- 14From: PLoS Pathogens. (Vol. 7, Issue 4) Peer-ReviewedMalaria threatens half the world's population and exacts a devastating human toll. The principal malaria vector in Africa, the mosquito Anopheles gambiae, encodes 24 members of a recently identified family of...
- 15From: PLoS Pathogens. (Vol. 7, Issue 4) Peer-ReviewedInfection of host cells by pathogenic microbes triggers signal transduction pathways leading to a multitude of host cell responses including actin cytoskeletal re-arrangements and transcriptional programs. The...
- 16From: PLoS Pathogens. (Vol. 7, Issue 4) Peer-ReviewedA type III secretion system (T3SS) in pathogenic Yersinia species functions to translocate Yop effectors, which modulate cytokine production and regulate cell death in macrophages. Distinct pathways of T3SS-dependent...
- 17From: PLoS Pathogens. (Vol. 7, Issue 4) Peer-ReviewedHuman cytomegalovirus (hCMV) is a highly prevalent pathogen that, upon primary infection, establishes life-long persistence in all infected individuals. Acute hCMV infections cause a variety of diseases in humans with...
- 18From: PLoS Pathogens. (Vol. 7, Issue 4) Peer-ReviewedCitrobacter rodentium is a natural mouse pathogen that causes attaching and effacing (A/E) lesions. It shares a common virulence strategy with the clinically significant human A/E pathogens enteropathogenic E. coli...
- 19From: PLoS Pathogens. (Vol. 7, Issue 4) Peer-ReviewedDNA Is a Potent Activator of Innate Immunity When a pathogen attacks, the immune system rapidly mobilizes host defenses in order to reduce the microbial burden and limit damage to the host [1]. Innate immunity is the...
- 20From: PLoS Pathogens. (Vol. 7, Issue 4) Peer-ReviewedKaposi's sarcoma (KS) lesions are complex mixtures of KS-associated herpesvirus (KSHV)-infected spindle and inflammatory cells. In order to survive the host immune responses, KSHV encodes a number of immunomodulatory...