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- 1From: Nature Methods. (Vol. 7, Issue 4) Peer-ReviewedBy stochastically sampling cells in groups of ten, the authors identify transcriptional programs with strong cell-to-cell expression differences thus allowing them to study endogenous heterogeneities in single cells....
- 2From: Nature Methods. (Vol. 7, Issue 4) Peer-ReviewedA side-view endoscope permits the imaging of large fields of gastrointestinal and respiratory mucosa at high resolution in the mouse. The approach is applied to imaging changes during inflammation and tumor progression...
- 3From: Nature Methods. (Vol. 7, Issue 4) Peer-ReviewedDirect observation of haplotypes is still technically challenging. Here we report a method for the determination of haplotypes through chromosome microdissection. We determined human long-range chromosomal haplotypes...
- 4From: Nature Methods. (Vol. 7, Issue 4) Peer-ReviewedProteins or small molecules designed to bind certain DNA sequences and to regulate target genes have much promise in both basic and applied research. But it is important that these tools be specific. As part of their...
- 5From: Nature Methods. (Vol. 7, Issue 4) Peer-ReviewedThe amazingly diverse roles of RNA molecules in biology are attracting increasing attention. Their varied biological functions are a result of the diversity of three-dimensional structures they adopt. However, the steps...
- 6From: Nature Methods. (Vol. 7, Issue 4) Peer-ReviewedCis-regulatory modules (CRMs) control gene expression as parts of complex regulatory networks. To experimentally validate CRMs, which are often identified based on computational predictions, Nam et al. recently...
- 7From: Nature Methods. (Vol. 7, Issue 4) Peer-ReviewedTo the Editor: Identifying disease-causing genetic variants in individual human genomes is a major challenge, even in protein-coding exons (the 'exome'). Analysis of nucleotide-level sequence conservation may help...
- 8From: Nature Methods. (Vol. 7, Issue 4) Peer-ReviewedWe extend the in vitro principle of co-immunoprecipitation to quantify dynamic protein interactions in living cells. Using a multiresolution implementation of fluorescence correlation spectroscopy to achieve maximal...
- 9From: Nature Methods. (Vol. 7, Issue 4) Peer-ReviewedBeing in the right place at the right time is a straightforward recipe for success. This also holds true for many bacteria that use syringe-like injection devices, such as the type-3 secretion system (T3SS), to deliver...
- 10From: Nature Methods. (Vol. 7, Issue 4) Peer-ReviewedPhilipp Korber from the University of Munich considers the view that there is a universal genomic code that determines nucleosome positioning a prominent hypothesis; one that he, together with colleagues and...
- 11From: Nature Methods. (Vol. 7, Issue 4) Peer-ReviewedMonitoring the behavior of single molecules in living cells is a powerful approach to investigate the details of cellular processes. Owing to their optical, chemical and biofunctional properties, semiconductor quantum...
- 12From: Nature Methods. (Vol. 7, Issue 4) Peer-ReviewedWhen Philippe Bastiaens considers the logic of cell signaling, his thoughts turn to termites. When they build nests, these insects sense where their colony-mates have dropped a sand grain and are more likely to leave...
- 13From: Nature Methods. (Vol. 7, Issue 4) Peer-ReviewedWe describe a Toxoplasma gondii strain that will permit the use of site-specific recombination to study the host-parasite interactions of this organism. This Toxoplasma strain efficiently injects a Cre fusion protein...
- 14From: Nature Methods. (Vol. 7, Issue 4) Peer-ReviewedHepatitis C virus (HCV) infects liver cells (hepatocytes) and can cause chronic hepatitis. As with other viruses, establishing a system to propagate this human pathogen in cell culture is key to better understand the...
- 15From: Nature Methods. (Vol. 7, Issue 4) Peer-ReviewedThe ability to tune the amounts of genes expressed in different cell types would permit more precise reverse genetic experiments. Schlabach et al. isolated strong synthetic enhancers by screening a library of 100-mer...
- 16From: Nature Methods. (Vol. 7, Issue 4) Peer-ReviewedBiomolecular dynamics and stability are predominantly investigated in vitro and extrapolated to explain function in the living cell. We present fast relaxation imaging (Frel), which combines fluorescence microscopy and...
- 17From: Nature Methods. (Vol. 7, Issue 4) Peer-ReviewedIt is challenging to solve the structures of large proteins by nuclear magnetic resonance (NMR) spectroscopy without resorting to deuterium labeling. Raman et al. show that protein structures of up to 25 kilodaltons can...
- 18From: Nature Methods. (Vol. 7, Issue 4) Peer-ReviewedTo the Editor: Applications of rapidly advancing sequencing technology exacerbate the need to interpret individual sequence variants. Sequencing of phenotyped clinical subjects will soon become a method of choice in...
- 19From: Nature Methods. (Vol. 7, Issue 4) Peer-ReviewedA couple years ago, Annika Enejder confronted confusing results from her studies of lipid storage in the roundworm Caenorhabditis elegans. Fluorescence microscopy images very clearly showed a decrease in signal from...
- 20From: Nature Methods. (Vol. 7, Issue 4) Peer-ReviewedIn vivo imaging of small animals offers several possibilities for studying normal and disease biology, but visualizing organs with single-cell resolution is challenging. We describe rotational side-view confocal...