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- 1From: PLoS Genetics. (Vol. 7, Issue 3) Peer-ReviewedThe ubiquitous tandem kinase JIL-1 is essential for Drosophila development. Its role in defining decondensed domains of larval polytene chromosomes is well established, but its involvement in transcription regulation...
- 2From: PLoS Genetics. (Vol. 7, Issue 3) Peer-ReviewedMore than 20 human neurological and neurodegenerative diseases are caused by simple DNA repeat expansions; among these, non-coding CTG repeat expansions are the basis of myotonic dystrophy (DM1). Recent work, however,...
- 3From: PLoS Genetics. (Vol. 7, Issue 3) Peer-ReviewedSomatic mutations of mtDNA are implicated in the aging process, but there is no universally accepted method for their accurate quantification. We have used ultra-deep sequencing to study genome-wide mtDNA mutation load...
- 4From: PLoS Genetics. (Vol. 7, Issue 3) Peer-ReviewedWhether evolution is erratic due to random historical details, or is repeatedly directed along similar paths by certain constraints, remains unclear. Epistasis (i.e. non-additive interaction between mutations that...
- 5From: PLoS Genetics. (Vol. 7, Issue 3) Peer-ReviewedMild mutations in BRCA2 (FANCD1) cause Fanconi anemia (FA) when homozygous, while severe mutations cause common cancers including breast, ovarian, and prostate cancers when heterozygous. Here we report a zebrafish brca2...
- 6From: PLoS Genetics. (Vol. 7, Issue 3) Peer-ReviewedPolycomb group (PcG) proteins bind and regulate hundreds of genes. Previous evidence has suggested that long-range chromatin interactions may contribute to the regulation of PcG target genes. Here, we adapted the...
- 7From: PLoS Genetics. (Vol. 7, Issue 3) Peer-ReviewedPlants need abundant nitrogen and phosphorus for higher yield. Improving plant genetics for higher nitrogen and phosphorus use efficiency would save potentially billions of dollars annually on fertilizers and reduce...
- 8From: PLoS Genetics. (Vol. 7, Issue 3) Peer-ReviewedHistone H3 lysine-4 (H3K4) methylation is associated with transcribed genes in eukaryotes. In Drosophila and mammals, both di- and tri-methylation of H3K4 are associated with gene activation. In contrast to animals, in...
- 9From: PLoS Genetics. (Vol. 7, Issue 3) Peer-ReviewedSomatic mutations contribute to the development of age-associated disease. In earlier work, we found that, at high frequency, aging Saccharomyces cerevisiae diploid cells produce daughters without mitochondrial DNA,...
- 10From: PLoS Genetics. (Vol. 7, Issue 3) Peer-ReviewedVarious types of genetic modification and selective forces have been implicated in the process of adaptation to novel or adverse environments. However, the underlying molecular mechanisms are not well understood in most...
- 11From: PLoS Genetics. (Vol. 7, Issue 3) Peer-ReviewedAsymmetrical segregation of differentiated sister chromatids is thought to be important for cellular differentiation in higher eukaryotes. Similarly, in fission yeast, cellular differentiation involves the asymmetrical...
- 12From: PLoS Genetics. (Vol. 7, Issue 3) Peer-ReviewedGenome sequence comparisons have highlighted many novel gene families that are conserved across animal phyla but whose biological function is unknown. Here, we functionally characterize a member of one such family, the...
- 13From: PLoS Genetics. (Vol. 7, Issue 3) Peer-ReviewedZinc is an essential trace element involved in a wide range of biological processes and human diseases. Zinc excess is deleterious, and animals require mechanisms to protect against zinc toxicity. To identify genes that...
- 14From: PLoS Genetics. (Vol. 7, Issue 3) Peer-ReviewedEukaryotic chromosomes occupy discrete territories with preferred positions within the cell nucleus, and establish extensive intra- and inter-chromosomal interactions. The mechanisms underlying chromatin interactions...
- 15From: PLoS Genetics. (Vol. 7, Issue 3) Peer-ReviewedAlthough ARS-interacting multifunctional protein 2 (AIMP2, also named as MSC p38) was first found as a component for a macromolecular tRNA synthetase complex, it was recently discovered to dissociate from the complex...
- 16From: PLoS Genetics. (Vol. 7, Issue 3) Peer-ReviewedGenome-wide interaction-based association (GWIBA) analysis has the potential to identify novel susceptibility loci. These interaction effects could be missed with the prevailing approaches in genome-wide association...
- 17From: PLoS Genetics. (Vol. 7, Issue 3) Peer-ReviewedNeuroblastoma is a malignant neoplasm of the developing sympathetic nervous system that is notable for its phenotypic diversity. High-risk patients typically have widely disseminated disease at diagnosis and a poor...
- 18From: PLoS Genetics. (Vol. 7, Issue 3) Peer-ReviewedChromatin structure and gene expression are regulated by posttranslational modifications (PTMs) on the N-terminal tails of histones. Mono-, di-, or trimethylation of lysine residues by histone lysine methyltransferases...
- 19From: PLoS Genetics. (Vol. 7, Issue 3) Peer-ReviewedIn recent years the functions that the p53 tumor suppressor plays in human biology have been greatly extended beyond "guardian of the genome." Our studies of promoter response element sequences targeted by the p53...
- 20From: PLoS Genetics. (Vol. 7, Issue 3) Peer-ReviewedTelomere integrity in budding yeast depends on the CST (Cdc13-Stn1-Ten1) and shelterin-like (Rap1-Rif1-Rif2) complexes, which are thought to act independently from each other. Here we show that a specific functional...