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- 1From: PLoS Pathogens. (Vol. 7, Issue 3) Peer-ReviewedA new variant of Creutzfeldt Jacob Disease (vCJD) was identified in humans and linked to the consumption of Bovine Spongiform Encephalopathy (BSE)-infected meat products. Recycling of ruminant tissue in meat and bone...
- 2From: PLoS Pathogens. (Vol. 7, Issue 3) Peer-ReviewedThe fungal pathogen Candida glabrata has risen from an innocuous commensal to a major human pathogen that causes life-threatening infections with an associated mortality rate of up to 50%. The dramatic rise in the...
- 3From: PLoS Pathogens. (Vol. 7, Issue 3) Peer-ReviewedPseudomonas syringae pv. phaseolicola is the causative agent of halo blight in the common bean, Phaseolus vulgaris. P. syringae pv. phaseolicola race 4 strain 1302A contains the avirulence gene avrPphB (syn. hopAR1),...
- 4From: PLoS Pathogens. (Vol. 7, Issue 3) Peer-ReviewedHighly pathogenic avian influenza (HPAI) H5N1 was first encountered in 1996 in Guangdong province (China) and started spreading throughout Asia and the western Palearctic in 2004-2006. Compared to several other...
- 5From: PLoS Pathogens. (Vol. 7, Issue 3) Peer-ReviewedMany pathogenic bacteria, fungi, and protozoa achieve chronic infection through an immune evasion strategy known as antigenic variation. In the human malaria parasite Plasmodium falciparum, this involves transcriptional...
- 6From: PLoS Pathogens. (Vol. 7, Issue 3) Peer-ReviewedThe presence of bacteria in the midgut of mosquitoes antagonizes infectious agents, such as Dengue and Plasmodium, acting as a negative factor in the vectorial competence of the mosquito. Therefore, knowledge of the...
- 7From: PLoS Pathogens. (Vol. 7, Issue 3) Peer-ReviewedListeria monocytogenes is a facultative intracellular bacterial pathogen that can infect the placenta, a chimeric organ made of maternal and fetal cells. Extravillous trophoblasts (EVT) are specialized fetal cells that...
- 8From: PLoS Pathogens. (Vol. 7, Issue 3) Peer-ReviewedPrion strains are characterized by differences in the outcome of disease, most notably incubation period and neuropathological features. While it is established that the disease specific isoform of the prion protein,...
- 9From: PLoS Pathogens. (Vol. 7, Issue 3) Peer-ReviewedHere we present the first global functional analysis of cellular responses to pore-forming toxins (PFTs). PFTs are uniquely important bacterial virulence factors, comprising the single largest class of bacterial protein...
- 10From: PLoS Pathogens. (Vol. 7, Issue 3) Peer-ReviewedIn Toxoplasma gondii, cis-acting elements present in promoter sequences of genes that are stage-specifically regulated have been described. However, the nuclear factors that bind to these c/s-acting elements and...
- 11From: PLoS Pathogens. (Vol. 7, Issue 3) Peer-ReviewedIxodid ticks are notorious blood-sucking ectoparasites and are completely dependent on blood-meals from hosts. In addition to the direct severe effects on health and productivity, ixodid ticks transmit various deadly...
- 12From: PLoS Pathogens. (Vol. 7, Issue 3) Peer-ReviewedHost defense against the intracellular pathogen Listeria monocytogenes (Lm) requires innate and adaptive immunity. Here, we directly imaged immune cell dynamics at Lm foci established by dendritic cells in the...
- 13From: PLoS Pathogens. (Vol. 7, Issue 3) Peer-ReviewedJaagsiekte sheep retrovirus (JSRV) is a unique oncogenic virus with distinctive biological properties. JSRV is the only virus causing a naturally occurring lung cancer (ovine pulmonary adenocarcinoma, OPA) and...
- 14From: PLoS Pathogens. (Vol. 7, Issue 3) Peer-ReviewedMalaria parasites must undergo a round of sexual reproduction in the blood meal of a mosquito vector to be transmitted between hosts. Developing a transmission-blocking intervention to prevent parasites from mating is a...
- 15From: PLoS Pathogens. (Vol. 7, Issue 3) Peer-ReviewedThe apicomplexan moving junction (MJ) is a highly conserved structure formed during host cell entry that anchors the invading parasite to the host cell and serves as a molecular sieve of host membrane proteins that...
- 16From: PLoS Pathogens. (Vol. 7, Issue 3) Peer-ReviewedTRIM proteins play important roles in the innate immune defense against retroviral infection, including human immunodeficiency virus type-1 (HIV-1). Rhesus macaque TRIM5[alpha] ([TRIM5[alpha].sub.rh]) targets the HIV-1...
- 17From: PLoS Pathogens. (Vol. 7, Issue 3) Peer-ReviewedMolecular interactions between killer immunoglobulin-like receptors (KIRs) and their MHC class I ligands play a central role in the regulation of natural killer (NK) cell responses to viral pathogens and tumors. Here we...
- 18From: PLoS Pathogens. (Vol. 7, Issue 3) Peer-ReviewedEncephalomyelitis Is an Unusual Complication of Infection with Encephalitic Viruses Viral encephalomyelitis is an important cause of morbidity and mortality worldwide, and many encephalitic viruses are emerging and...
- 19From: PLoS Pathogens. (Vol. 7, Issue 3) Peer-ReviewedThe host innate immune response to viral infections often involves the activation of parallel pattern recognition receptor (PRR) pathways that converge on the induction of type I interferons (IFNs). Several viruses have...
- 20From: PLoS Pathogens. (Vol. 7, Issue 3) Peer-ReviewedBotulinum neurotoxins (BoNTs) include seven bacterial toxins (BoNT/A-G) that target presynaptic terminals and act as proteases cleaving proteins required for synaptic vesicle exocytosis. Here we identified synaptic...