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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 7AndIssue Number: 2AndStart Page: e1001308AndDate: 2011 Revise Search
- 1From: PLoS Genetics. (Vol. 7, Issue 2) Peer-Reviewedoronary heart disease (CHD) is the leading cause of mortality in African Americans. To identify common genetic polymorphisms associated with CHD and its risk factors (LDL- and HDL-cholesterol (LDL-C and HDL-C),...
- 2From: PLoS Genetics. (Vol. 7, Issue 2) Peer-ReviewedHomologous recombination in meiosis is initiated by the programmed induction of double strand breaks (DSBs). Although the Drosophila Spo11 ortholog Mei-W68 is required for the induction of DSBs during meiotic prophase,...
- 3From: PLoS Genetics. (Vol. 7, Issue 2) Peer-ReviewedHuman intervention has subjected the yeast Saccharomyces cerevisiae to multiple rounds of independent domestication and thousands of generations of artificial selection. As a result, this species comprises a genetically...
- 4From: PLoS Genetics. (Vol. 7, Issue 2) Peer-ReviewedPrimary open angle glaucoma (POAG) is a leading cause of blindness worldwide, with elevated intraocular pressure as an important risk factor. Increased resistance to outflow of aqueous humor through the trabecular...
- 5From: PLoS Genetics. (Vol. 7, Issue 2) Peer-ReviewedPreterm birth is the major cause of neonatal death and serious morbidity. Most preterm births are due to spontaneous onset of labor without a known cause or effective prevention. Both maternal and fetal genomes...
- 6From: PLoS Genetics. (Vol. 7, Issue 2) Peer-ReviewedThe protein complex known as cohesin binds pericentric regions and other sites of eukaryotic genomes to mediate cohesion of sister chromatids. In budding yeast Saccharomyces cerevisiae, cohesin also binds silent...
- 7From: PLoS Genetics. (Vol. 7, Issue 2) Peer-ReviewedThe glaucomas comprise a genetically complex group of retinal neuropathies that typically occur late in life and are characterized by progressive pathology of the optic nerve head and degeneration of retinal ganglion...
- 8From: PLoS Genetics. (Vol. 7, Issue 2) Peer-ReviewedLipids are constantly shuttled through the body to redistribute energy and metabolites between sites of absorption, storage, and catabolism in a complex homeostatic equilibrium. In Drosophila, lipids are transported...
- 9From: PLoS Genetics. (Vol. 7, Issue 2) Peer-ReviewedEpidemiology and candidate gene studies indicate a shared genetic basis for celiac disease (CD) and rheumatoid arthritis (RA), but the extent of this sharing has not been systematically explored. Previous studies...
- 10From: PLoS Genetics. (Vol. 7, Issue 2) Peer-ReviewedHow epigenetic information is propagated during somatic cell divisions is still unclear but is absolutely critical for preserving gene expression patterns and cellular identity. Here we show an unanticipated mechanism...
- 11From: PLoS Genetics. (Vol. 7, Issue 2) Peer-ReviewedDuring Alzheimer's Disease, sustained exposure to amyloid-[[beta].sub.42] oligomers perturbs metabolism of ether-linked glycerophospholipids defined by a saturated 16 carbon chain at the sn-1 position. The intraneuronal...
- 12From: PLoS Genetics. (Vol. 7, Issue 2) Peer-ReviewedRapid advances in sequencing technologies set the stage for the large-scale medical sequencing efforts to be performed in the near future, with the goal of assessing the importance of rare variants in complex diseases....
- 13From: PLoS Genetics. (Vol. 7, Issue 2) Peer-ReviewedLeaf-cutter ants are one of the most important herbivorous insects in the Neotropics, harvesting vast quantities of fresh leaf material. The ants use leaves to cultivate a fungus that serves as the colony's primary food...
- 14From: PLoS Genetics. (Vol. 7, Issue 2) Peer-ReviewedSystemic lupus erythematosus (SLE) is a genetically complex disease with heterogeneous clinical manifestations. Recent studies have greatly expanded the number of established SLE risk alleles, but the distribution of...
- 15From: PLoS Genetics. (Vol. 7, Issue 2) Peer-ReviewedThe modification of DNA by methylation is an important epigenetic mechanism that affects the spatial and temporal regulation of gene expression. Methylation patterns have been described in many contexts within and...
- 16From: PLoS Genetics. (Vol. 7, Issue 2) Peer-ReviewedSeed development in angiosperms is dependent on the interplay among different transcriptional programs operating in the embryo, the endosperm, and the maternally-derived seed coat. In angiosperms, the embryo and the...
- 17From: PLoS Genetics. (Vol. 7, Issue 2) Peer-ReviewedThe surface proteins of human influenza A viruses experience positive selection to escape both human immunity and, more recently, antiviral drug treatments. In bacteria and viruses, immune-escape and drug-resistant...
- 18From: PLoS Genetics. (Vol. 7, Issue 2) Peer-ReviewedRecent research has provided mechanistic insight into the important contributions of the gut microbiota to vertebrate biology, but questions remain about the evolutionary processes that have shaped this symbiosis. In...
- 19From: PLoS Genetics. (Vol. 7, Issue 2) Peer-ReviewedCell-to-cell communication is crucial for the development of multicellular organisms, especially during the generation of new tissues and organs. Secondary growth--the lateral expansion of plant growth axes--is a highly...
- 20From: PLoS Genetics. (Vol. 7, Issue 2) Peer-ReviewedTranscription of the switch (S) regions of immunoglobulin genes in B cells generates stable R-loops that are targeted by Activation Induced Cytidine Deaminase (AID), triggering class switch recombination (CSR), as well...