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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 7AndIssue Number: 12AndStart Page: e1002393AndDate: 2011 Revise Search
- 1From: PLoS Genetics. (Vol. 7, Issue 12) Peer-ReviewedThree years ago, a member of my university's project management team came by my office with a set of Bose noise-canceling headphones and some advice: "You're going to need these." And indeed I did, as just outside my...
- 2From: PLoS Genetics. (Vol. 7, Issue 12) Peer-ReviewedHomeostasis of most adult tissues is maintained by balancing stem cell self-renewal and differentiation, but whether posttranscriptional mechanisms can regulate this process is unknown. Here, we identify that an RNA...
- 3From: PLoS Genetics. (Vol. 7, Issue 12) Peer-ReviewedThe grass smuts comprise a speciose group of biotrophic plant parasites, so-called Ustilaginaceae, which are specifically adapted to hosts of sweet grasses, the Poaceae family. Mating takes a central role in their life...
- 4From: PLoS Genetics. (Vol. 7, Issue 12) Peer-ReviewedSeveral highly conserved genes play a role in anterior neural plate patterning of vertebrates and in head and brain patterning of insects. However, head involution in Drosophila has impeded a systematic identification...
- 5From: PLoS Genetics. (Vol. 7, Issue 12) Peer-ReviewedComplex diseases and traits are likely influenced by many common and rare genetic variants and environmental factors. Detecting disease susceptibility variants is a challenging task, especially when their frequencies...
- 6From: PLoS Genetics. (Vol. 7, Issue 12) Peer-ReviewedThe epidermis is the largest organ of the body for most animals, and the first line of defense against invading pathogens. A breach in the epidermal cell layer triggers a variety of localized responses that in favorable...
- 7From: PLoS Genetics. (Vol. 7, Issue 12) Peer-ReviewedPituitary tumors are common intracranial neoplasms, yet few germline abnormalities have been implicated in their pathogenesis. Here we show that a single nucleotide germline polymorphism (SNP) substituting an arginine...
- 8From: PLoS Genetics. (Vol. 7, Issue 12) Peer-ReviewedIn a sample of 3,187 twins and 3,294 of their parents, we sought to investigate association of both individual variants and a genotype-based height score involving 176 of the 180 common genetic variants with adult...
- 9From: PLoS Genetics. (Vol. 7, Issue 12) Peer-ReviewedThe insulin/IGF-activated AKT signaling pathway plays a crucial role in regulating tissue growth and metabolism in multicellular animals. Although core components of the pathway are well defined, less is known about...
- 10From: PLoS Genetics. (Vol. 7, Issue 12) Peer-ReviewedTripartite Motif (TRIM) ubiquitin ligases act in the innate immune response against viruses. One of the best characterized members of this family, TRIM5[alpha], serves as a potent retroviral restriction factor with...
- 11From: PLoS Genetics. (Vol. 7, Issue 12) Peer-ReviewedMicroRNAs (miRNAs) are important components of cellular signaling pathways, acting either as pathway regulators or pathway targets. Currently, only a limited number of miRNAs have been functionally linked to specific...
- 12From: PLoS Genetics. (Vol. 7, Issue 12) Peer-ReviewedCorneal astigmatism refers to refractive abnormalities and irregularities in the curvature of the cornea, and this interferes with light being accurately focused at a single point in the eye. This ametropic condition is...
- 13From: PLoS Genetics. (Vol. 7, Issue 12) Peer-ReviewedRNA-directed DNA methylation (RdDM) is an epigenetic control mechanism driven by small interfering RNAs (siRNAs) that influence gene function. In plants, little is known of the involvement of the RdDM pathway in...
- 14From: PLoS Genetics. (Vol. 7, Issue 12) Peer-ReviewedThe Caenorhabditis elegans class A and B synthetic multivulva (synMuv) genes redundantly antagonize an EGF/Ras pathway to prevent ectopic vulval induction. We identify a class A synMuv mutation in the promoter of the...
- 15From: PLoS Genetics. (Vol. 7, Issue 12) Peer-ReviewedDNA methylation plays an important role in development and disease. The primary sites of DNA methylation in vertebrates are cytosines in the CpG dinucleotide context, which account for roughly three quarters of the...
- 16From: PLoS Genetics. (Vol. 7, Issue 12) Peer-ReviewedCommon genetic variants have been shown to explain a fraction of the inherited variation for many common diseases and quantitative traits, including height, a classic polygenic trait. The extent to which common...
- 17From: PLoS Genetics. (Vol. 7, Issue 12) Peer-ReviewedNeuronal degeneration is a hallmark of many DNA repair syndromes. Yet, how DNA damage causes neuronal degeneration and whether defects in different repair systems affect the brain differently is largely unknown. Here,...
- 18From: PLoS Genetics. (Vol. 7, Issue 12) Peer-ReviewedCaenorhabditis elegans ftn-1 and ftn-2, which encode the iron-storage protein ferritin, are transcriptionally inhibited during iron deficiency in intestine. Intestinal specific transcription is dependent on binding of...
- 19From: PLoS Genetics. (Vol. 7, Issue 12) Peer-ReviewedThe ribosome is critical for all aspects of cell growth due to its essential role in protein synthesis. Paradoxically, many Ribosomal proteins (Rps) act as tumour suppressors in Drosophila and vertebrates. To examine...
- 20From: PLoS Genetics. (Vol. 7, Issue 12) Peer-ReviewedEukaryotic genomes are partitioned into active and inactive domains called euchromatin and heterochromatin, respectively. In Neurospora crassa, heterochromatin formation requires methylation of histone H3 at lysine 9...