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- Search Terms:ISSN: 15537366AndISSN: 15537374AndVolume Number: 7AndIssue Number: 12AndStart Page: e1002442AndDate: 2011 Revise Search
- 1From: PLoS Pathogens. (Vol. 7, Issue 12) Peer-ReviewedVaccinia virus (VACV) protein N1 is an intracellular virulence factor and belongs to a family of VACV B-cell lymphoma (Bcl)-2-like proteins whose members inhibit apoptosis or activation of pro-inflammatory transcription...
- 2From: PLoS Pathogens. (Vol. 7, Issue 12) Peer-ReviewedHuman cytomegalovirus (CMV) exerts diverse and complex effects on the immune system, not all of which have been attributed to viral genes. Acute CMV infection results in transient restrictions in T cell proliferative...
- 3From: PLoS Pathogens. (Vol. 7, Issue 12) Peer-ReviewedAfter oral exposure, prions are thought to enter Peyer's patches via M cells and accumulate first upon follicular dendritic cells (FDCs) before spreading to the nervous system. How prions are actually initially acquired...
- 4From: PLoS Pathogens. (Vol. 7, Issue 12) Peer-ReviewedThe transmissible agent of prion disease consists of a prion protein in its abnormal, [beta]-sheet rich state ([PrP.sup.Sc]), which is capable of replicating itself according to the template-assisted mechanism. This...
- 5From: PLoS Pathogens. (Vol. 7, Issue 12) Peer-ReviewedCandida sp. are opportunistic fungal pathogens that colonize the skin and oral cavity and, when overgrown under permissive conditions, cause inflammation and disease. Previously, we identified a central role for the...
- 6From: PLoS Pathogens. (Vol. 7, Issue 12) Peer-ReviewedInfected animals will produce reactive oxygen species (ROS) and other inflammatory molecules that help fight pathogens, but can inadvertently damage host tissue. Therefore specific responses, which protect and repair...
- 7From: PLoS Pathogens. (Vol. 7, Issue 12) Peer-ReviewedHantavirus pulmonary syndrome (HPS), also referred to as hantavirus cardiopulmonary syndrome (HCPS), is a rare but frequently fatal disease caused by New World hantaviruses. In humans HPS is associated with severe...
- 8From: PLoS Pathogens. (Vol. 7, Issue 12) Peer-ReviewedThe adaptation of Chikungunya virus (CHIKV) to a new vector, the Aedes albopictus mosquito, is a major factor contributing to its ongoing re-emergence in a series of large-scale epidemics of arthritic disease in many...
- 9From: PLoS Pathogens. (Vol. 7, Issue 12) Peer-ReviewedChikungunya virus (CHIKV) is an alphavirus responsible for numerous epidemics throughout Africa and Asia, causing infectious arthritis and reportedly linked with fatal infections in newborns and elderly. Previous...
- 10From: PLoS Pathogens. (Vol. 7, Issue 12) Peer-ReviewedEffectors of the bacterial type III secretion system provide invaluable molecular probes to elucidate the molecular mechanisms of plant immunity and pathogen virulence. In this report, we focus on the AvrBs2 effector...
- 11From: PLoS Pathogens. (Vol. 7, Issue 12) Peer-ReviewedAutophagy is a conserved degradative pathway used as a host defense mechanism against intracellular pathogens. However, several viruses can evade or subvert autophagy to insure their own replication. Nevertheless, the...
- 12From: PLoS Pathogens. (Vol. 7, Issue 12) Peer-ReviewedWhile the contribution of [CD8.SUP.+] cytotoxic T lymphocytes to early containment of HIV-1 spread is well established, a role for NK cells in controlling HIV-1 replication during primary infection has been uncertain....
- 13From: PLoS Pathogens. (Vol. 7, Issue 12) Peer-ReviewedCytotoxic T lymphocytes (CTLs) are the major killer of virus-infected cells. Granzyme B (GrB) from CTLs induces apoptosis in target cells by cleavage and activation of substrates like caspase-3 and Bid. However, while...
- 14From: PLoS Pathogens. (Vol. 7, Issue 12) Peer-ReviewedAnthrax is a potentially fatal disease resulting from infection with Bacillus anthracis. The outcome of infection is influenced by pathogen-encoded virulence factors such as lethal toxin (LT), as well as by genetic...
- 15From: PLoS Pathogens. (Vol. 7, Issue 12) Peer-ReviewedCellular receptors can act as molecular switches, regulating the sensitivity of microbial proteins to conformational changes that promote cellular entry. The activities of these receptor-based switches are only...
- 16From: PLoS Pathogens. (Vol. 7, Issue 12) Peer-ReviewedA previous study identified MoRgs1 as an RGS protein that negative regulates G-protein signaling to control developmental processes such as conidiation and appressorium formation in Magnaporthe oryzae. Here, we...
- 17From: PLoS Pathogens. (Vol. 7, Issue 12) Peer-ReviewedSpatial and numerical regulation of flagellar biosynthesis results in different flagellation patterns specific for each bacterial species. Campylobacter jejuni produces amphitrichous (bipolar) flagella to result in a...
- 18From: PLoS Pathogens. (Vol. 7, Issue 12) Peer-ReviewedSARS coronavirus (SCoV) nonstructural protein (nsp) 1, a potent inhibitor of host gene expression, possesses a unique mode of action: it binds to 40S ribosomes to inactivate their translation functions and induces host...
- 19From: PLoS Pathogens. (Vol. 7, Issue 12) Peer-ReviewedVirus assembly and interaction with host-cell proteins occur at length scales below the diffraction limit of visible light. Novel super-resolution microscopy techniques achieve nanometer resolution of fluorescently...
- 20From: PLoS Pathogens. (Vol. 7, Issue 12) Peer-ReviewedHighly pathogenic avian influenza viruses of the H5N1 subtype continue to threaten agriculture and human health. Here, we use biochemistry and x-ray crystallography to reveal how amino-acid variations in the...