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- 1From: PLoS Computational Biology. (Vol. 7, Issue 12) Peer-ReviewedCombinatorial therapy is a promising strategy for combating complex disorders due to improved efficacy and reduced side effects. However, screening new drug combinations exhaustively is impractical considering all...
- 2From: PLoS Computational Biology. (Vol. 7, Issue 12) Peer-ReviewedStimulus properties, attention, and behavioral context influence correlations between the spike times produced by a pair of neurons. However, the biophysical mechanisms that modulate these correlations are poorly...
- 3From: PLoS Computational Biology. (Vol. 7, Issue 12) Peer-ReviewedCytosolic 5'-nucleotidase II (cN-II) regulates the intracellular nucleotide pools within the cell by catalyzing the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates. Beside this physiological function,...
- 4From: PLoS Computational Biology. (Vol. 7, Issue 12) Peer-ReviewedTimely, and sometimes rapid, metabolic adaptation to changes in food supply is critical for survival as an organism moves from the fasted to the fed state, and vice versa. These transitions necessitate major metabolic...
- 5From: PLoS Computational Biology. (Vol. 7, Issue 12) Peer-ReviewedBecause cytotoxic T-lymphocytes (CTLs) have been shown to play a role in controlling human immunodeficiency virus (HIV) infection and because CTL-based simian immunodeficiency virus (SIV) vaccines have proved effective...
- 6From: PLoS Computational Biology. (Vol. 7, Issue 12) Peer-ReviewedIn an active, self-ubiquitinated state, the Ring1B ligase monoubiquitinates histone H2A playing a critical role in Polycomb-mediated gene silencing. Following ubiquitination by external ligases, Ring1B is targeted for...
- 7From: PLoS Computational Biology. (Vol. 7, Issue 12) Peer-ReviewedOpen source and open data have been driving forces in bioinformatics in the past. However, privacy concerns may soon change the landscape, limiting future access to important data sets, including personal genomics data....
- 8From: PLoS Computational Biology. (Vol. 7, Issue 12) Peer-ReviewedGeneration of induced pluripotent stem cells (iPSCs) opens a new avenue in regenerative medicine. One of the major hurdles for therapeutic applications is to improve the efficiency of generating iPSCs and also to avoid...
- 9From: PLoS Computational Biology. (Vol. 7, Issue 12) Peer-ReviewedThe recognition of cryptic small molecular binding sites in protein structures is important for understanding off target side effects and for recognizing potential new indications for existing drugs. Current methods...
- 10From: PLoS Computational Biology. (Vol. 7, Issue 12) Peer-ReviewedDrug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic...
- 11From: PLoS Computational Biology. (Vol. 7, Issue 12) Peer-ReviewedLiving systems are capable of processing multiple sources of information simultaneously. This is true even at the cellular level, where not only coexisting signals stimulate the cell, but also the presence of...
- 12From: PLoS Computational Biology. (Vol. 7, Issue 12) Peer-ReviewedIllumina whole-genome expression BeadArrays are a popular choice in gene profiling studies. Aside from the vendor-provided software tools for analyzing BeadArray expression data (GenomeStudio/BeadStudio), there exists a...
- 13From: PLoS Computational Biology. (Vol. 7, Issue 12) Peer-ReviewedThe sensory-motor neuron synapse of Aplysia is an excellent model system for investigating the biochemical changes underlying memory formation. In this system, training that is separated by rest periods (spaced...
- 14From: PLoS Computational Biology. (Vol. 7, Issue 12) Peer-ReviewedInteraction between the hepatitis C virus (HCV) envelope protein E2 and the host receptor CD81 is essential for HCV entry into target cells. The number of E2-CD81 complexes necessary for HCV entry has remained difficult...
- 15From: PLoS Computational Biology. (Vol. 7, Issue 12) Peer-ReviewedShort-term presynaptic plasticity designates variations of the amplitude of synaptic information transfer whereby the amount of neurotransmitter released upon presynaptic stimulation changes over seconds as a function...
- 16From: PLoS Computational Biology. (Vol. 7, Issue 12) Peer-ReviewedFood webs, networks of feeding relationships in an ecosystem, provide fundamental insights into mechanisms that determine ecosystem stability and persistence. A standard approach in food-web analysis, and network...
- 17From: PLoS Computational Biology. (Vol. 7, Issue 12) Peer-ReviewedRed blood cells (RBCs) infected by a Plasmodium parasite in malaria may lose their membrane deformability with a relative membrane stiffening more than ten-fold in comparison with healthy RBCs leading to potential...
- 18From: PLoS Computational Biology. (Vol. 7, Issue 12) Peer-ReviewedRhinolophidae or Horseshoe bats emit long and narrowband calls. Fluttering insect prey generates echoes in which amplitude and frequency shifts are present, i.e. glints. These glints are reliable cues about the presence...
- 19From: PLoS Computational Biology. (Vol. 7, Issue 12) Peer-ReviewedConformational changes in allosteric regulation can to a large extent be described as motion along one or a few coherent degrees of freedom. The states involved are inherent to the protein, in the sense that they are...
- 20From: PLoS Computational Biology. (Vol. 7, Issue 12) Peer-ReviewedHistone tails play an important role in nucleosome structure and dynamics. Here we investigate the effect of truncation of histone tails H3, H4, H2A and H2B on nucleosome structure with 100 ns all-atom molecular...