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- 1From: PLoS Genetics. (Vol. 7, Issue 11) Peer-ReviewedArabidopsis TSO1 encodes a protein with conserved CXC domains known to bind DNA and is homologous to animal proteins that function in chromatin complexes. tso1 mutants fall into two classes due to their distinct...
- 2From: PLoS Genetics. (Vol. 7, Issue 11) Peer-ReviewedChromatin assembly mutants accumulate recombinogenic DNA damage and are sensitive to genotoxic agents. Here we have analyzed why impairment of the H3K56 acetylation-dependent CAF1 and Rtt106 chromatin assembly pathways,...
- 3From: PLoS Genetics. (Vol. 7, Issue 11) Peer-ReviewedPrevious genome-wide scans of positive natural selection in humans have identified a number of non-neutrally evolving genes that play important roles in skin pigmentation, metabolism, or immune function. Recent studies...
- 4From: PLoS Genetics. (Vol. 7, Issue 11) Peer-ReviewedEndogenous small interfering RNAs (siRNAs) are a class of naturally occuring regulatory RNAs found in fungi, plants, and animals. Some endogenous siRNAs are required to silence transposons or function in chromosome...
- 5From: PLoS Genetics. (Vol. 7, Issue 11) Peer-ReviewedEndoplasmic reticulum (ER) stress activates the Unfolded Protein Response, a compensatory signaling response that is mediated by the IRE-1, PERK/PEK-1, and ATF-6 pathways in metazoans. Genetic studies have implicated...
- 6From: PLoS Genetics. (Vol. 7, Issue 11) Peer-ReviewedThe de novo origin of a new protein-coding gene from non-coding DNA is considered to be a very rare occurrence in genomes. Here we identify 60 new protein-coding genes that originated de novo on the human lineage since...
- 7From: PLoS Genetics. (Vol. 7, Issue 11) Peer-ReviewedThe regulatory logic of time- and tissue-specific gene expression has mostly been dissected in the context of the smallest DNA fragments that, when isolated, recapitulate native expression in reporter assays. It is not...
- 8From: PLoS Genetics. (Vol. 7, Issue 11) Peer-ReviewedAs the interface between a microbe and its environment, the bacterial cell envelope has broad biological and clinical significance. While numerous biosynthesis genes and pathways have been identified and studied in...
- 9From: PLoS Genetics. (Vol. 7, Issue 11) Peer-ReviewedSodalis glossinidius, a maternally inherited endosymbiont of the tsetse fly, maintains genes encoding homologues of the PhoP-PhoQ two-component regulatory system. This two-component system has been extensively studied...
- 10From: PLoS Genetics. (Vol. 7, Issue 11) Peer-ReviewedEpigenetic variation describes heritable differences that are not attributable to changes in DNA sequence. There is the potential for pure epigenetic variation that occurs in the absence of any genetic change or for...
- 11From: PLoS Genetics. (Vol. 7, Issue 11) Peer-ReviewedMany signaling proteins including G protein-coupled receptors localize to primary cilia, regulating cellular processes including differentiation, proliferation, organogenesis, and tumorigenesis. Bardet-Biedl Syndrome...
- 12From: PLoS Genetics. (Vol. 7, Issue 11) Peer-ReviewedDuplications play a significant role in both extremes of the phenotypic spectrum of newly arising mutations: they can have severe deleterious effects (e.g. duplications underlie a variety of diseases) but can also be...
- 13From: PLoS Genetics. (Vol. 7, Issue 11) Peer-ReviewedUbiquitylation is fundamental for the regulation of the stability and function of p53 and c-Myc. The E3 ligase Pirh2 has been reported to polyubiquitylate p53 and to mediate its proteasomal degradation. Here, using...
- 14From: PLoS Genetics. (Vol. 7, Issue 11) Peer-ReviewedThe budding yeast spindle pole body (SPB) is anchored in the nuclear envelope so that it can simultaneously nucleate both nuclear and cytoplasmic microtubules. During SPB duplication, the newly formed SPB is inserted...
- 15From: PLoS Genetics. (Vol. 7, Issue 11) Peer-ReviewedWhere do new genes come from? For a long time the answer to that question has simply been "from other genes". The most prolific source of new loci in eukaryotic genomes is gene duplication in all its guises: exon...
- 16From: PLoS Genetics. (Vol. 7, Issue 11) Peer-ReviewedMost genes in bacteria are experimentally uncharacterized and cannot be annotated with a specific function. Given the great diversity of bacteria and the ease of genome sequencing, high-throughput approaches to identify...
- 17From: PLoS Genetics. (Vol. 7, Issue 11) Peer-ReviewedIn most species, crossovers (COs) are essential for the accurate segregation of homologous chromosomes at the first meiotic division. Their number and location are tightly regulated. Here, we report a detailed,...
- 18From: PLoS Genetics. (Vol. 7, Issue 11) Peer-ReviewedAltered transcriptional programs are a hallmark of diseases, yet how these are established is still ill-defined. PBX1 is a TALE homeodomain protein involved in the development of different types of cancers. The estrogen...
- 19From: PLoS Genetics. (Vol. 7, Issue 11) Peer-ReviewedThe forkhead transcription factor Foxn1 is indispensable for thymus development, but the mechanisms by which it mediates thymic epithelial cell (TEC) development are poorly understood. To examine the cellular and...
- 20From: PLoS Genetics. (Vol. 7, Issue 11) Peer-ReviewedCell proliferation and differentiation are regulated in a highly coordinated and inverse manner during development and tissue homeostasis. Terminal differentiation usually coincides with cell cycle exit and is thought...