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- Search Terms:ISSN: 1553734XAndISSN: 15537358AndVolume Number: 7AndIssue Number: 10AndStart Page: e1002225AndDate: 2011 Revise Search
- 1From: PLoS Computational Biology. (Vol. 7, Issue 10) Peer-ReviewedOne of the hallmarks of biological organisms is their ability to integrate disparate information sources to optimize their behavior in complex environments. How this capability can be quantified and related to the...
- 2From: PLoS Computational Biology. (Vol. 7, Issue 10) Peer-ReviewedOur ability to recreate complex biochemical mechanisms in designed, artificial systems provides a stringent test of our understanding of these mechanisms and opens the door to their exploitation in artificial...
- 3From: PLoS Computational Biology. (Vol. 7, Issue 10) Peer-ReviewedSparse coding algorithms trained on natural images can accurately predict the features that excite visual cortical neurons, but it is not known whether such codes can be learned using biologically realistic plasticity...
- 4From: PLoS Computational Biology. (Vol. 7, Issue 10) Peer-ReviewedA scientific community consists of scientists working in a particular field of science and, most importantly, of their relationships and interactions. Beyond the traditional publication of research projects, discussions...
- 5From: PLoS Computational Biology. (Vol. 7, Issue 10) Peer-ReviewedTransmembrane [alpha]-helices play a key role in many receptors, transmitting a signal from one side to the other of the lipid bilayer membrane. Bacterial chemoreceptors are one of the best studied such systems, with a...
- 6From: PLoS Computational Biology. (Vol. 7, Issue 10) Peer-ReviewedSomitogenesis, the formation of the body's primary segmental structure common to all vertebrate development, requires coordination between biological mechanisms at several scales. Explaining how these mechanisms...
- 7From: PLoS Computational Biology. (Vol. 7, Issue 10) Peer-ReviewedMessenger RNA splicing is an essential and complex process for the removal of intron sequences. Whereas the composition of the splicing machinery is mostly known, the kinetics of splicing, the catalytic activity of...
- 8From: PLoS Computational Biology. (Vol. 7, Issue 10) Peer-ReviewedThe motion of ions, molecules or proteins in dendrites is restricted by cytoplasmic obstacles such as organelles, microtubules and actin network. To account for molecular crowding, we study the effect of diffusion...
- 9From: PLoS Computational Biology. (Vol. 7, Issue 10) Peer-ReviewedNetwork analysis became a powerful tool giving new insights to the understanding of cellular behavior. Heat shock, the archetype of stress responses, is a well-characterized and simple model of cellular dynamics. S....
- 10From: PLoS Computational Biology. (Vol. 7, Issue 10) Peer-ReviewedThe main adaptive immune response to bacteria is mediated by B cells and CD4+ T-cells. However, some bacterial proteins reach the cytosol of host cells and are exposed to the host CD8+ T-cells response. Both...
- 11From: PLoS Computational Biology. (Vol. 7, Issue 10) Peer-ReviewedMonoamine transporters are responsible for termination of synaptic signaling and are involved in depression, control of appetite, and anxiety amongst other neurological processes. Despite extensive efforts, the...
- 12From: PLoS Computational Biology. (Vol. 7, Issue 10) Peer-ReviewedTurnover of regulatory sequence and function is an important part of molecular evolution. But what are the modes of sequence evolution leading to rapid formation and loss of regulatory sites? Here we show that a large...
- 13From: PLoS Computational Biology. (Vol. 7, Issue 10) Peer-ReviewedReinforcement learning (RL) provides an influential characterization of the brain's mechanisms for learning to make advantageous choices. An important problem, though, is how complex tasks can be represented in a way...
- 14From: PLoS Computational Biology. (Vol. 7, Issue 10) Peer-ReviewedConventional methods used to characterize multidimensional neural feature selectivity, such as spike-triggered covariance (STC) or maximally informative dimensions (MID), are limited to Gaussian stimuli or are only able...
- 15From: PLoS Computational Biology. (Vol. 7, Issue 10) Peer-ReviewedFarnesylation is an important post-translational modification catalyzed by farnesyltransferase (FTase). Until recently it was believed that a C-terminal CaaX motif is required for farnesylation, but recent experiments...
- 16From: PLoS Computational Biology. (Vol. 7, Issue 10) Peer-ReviewedThe current article suggests that deterministic chaos self-organized in cortical dynamics could be responsible for the generation of spontaneous action sequences. Recently, various psychological observations have...
- 17From: PLoS Computational Biology. (Vol. 7, Issue 10) Peer-ReviewedThe tumor suppressor protein p53 can lose its function upon single-point missense mutations in the core DNA-binding domain ("cancer mutants"). Activity can be restored by second-site suppressor mutations ("rescue...
- 18From: PLoS Computational Biology. (Vol. 7, Issue 10) Peer-ReviewedRecent evidence from serum metabolomics indicates that specific metabolic disturbances precede [beta]-cell autoimmunity in humans and can be used to identify those children who subsequently progress to type 1 diabetes....
- 19From: PLoS Computational Biology. (Vol. 7, Issue 10) Peer-ReviewedExtensive experimental information supports the formation of ligand-specific conformations of G protein-coupled receptors (GPCRs) as a possible molecular basis for their functional selectivity for signaling pathways....
- 20From: PLoS Computational Biology. (Vol. 7, Issue 10) Peer-ReviewedReperfusion injury results from pathologies of cardiac myocyte physiology that develop when previously ischemic myocardium experiences a restoration of normal perfusion. Events in the development of reperfusion injury...