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- 1From: PLoS Genetics. (Vol. 7, Issue 1) Peer-ReviewedGenome-wide association studies (GWAS) have defined over 150 genomic regions unequivocally containing variation predisposing to immune-mediated disease. Inferring disease biology from these observations, however, hinges...
- 2From: PLoS Genetics. (Vol. 7, Issue 1) Peer-ReviewedEven within a defined cell type, the expression level of a gene differs in individual samples. The effects of genotype, measured factors such as environmental conditions, and their interactions have been explored in...
- 3From: PLoS Genetics. (Vol. 7, Issue 1) Peer-ReviewedSugars are evolutionarily conserved signaling molecules that regulate the growth and development of both unicellular and multicellular organisms. As sugar-producing photosynthetic organisms, plants utilize glucose as...
- 4From: PLoS Genetics. (Vol. 7, Issue 1) Peer-ReviewedGene duplication followed by neo- or sub-functionalization deeply impacts the evolution of protein families and is regarded as the main source of adaptive functional novelty in eukaryotes. While there is ample evidence...
- 5From: PLoS Genetics. (Vol. 7, Issue 1) Peer-ReviewedLoss of retinoblastoma (Rb) tumor suppressor function is associated with human malignancies. Molecular and genetic mechanisms responsible for tumorigenic Rb downregulation are not fully defined. Through a forward...
- 6From: PLoS Genetics. (Vol. 7, Issue 1) Peer-ReviewedThe application of deep sequencing to map 5' capped transcripts has confirmed the existence of at least two distinct promoter classes in metazoans: "focused" promoters with transcription start sites (TSSs) that occur in...
- 7From: PLoS Genetics. (Vol. 7, Issue 1) Peer-ReviewedGenetic variants altering cis-regulation of normal gene expression (cis-eQTLs) have been extensively mapped in human cells and tissues, but the extent by which controlled, environmental perturbation influences cis-eQTLs...
- 8From: PLoS Genetics. (Vol. 7, Issue 1) Peer-ReviewedGenome-wide association studies (GWAS) have identified more than 2,000 trait-SNP associations, and the number continues to increase. GWAS have focused on traits with potential consequences for human fitness, including...
- 9From: PLoS Genetics. (Vol. 7, Issue 1) Peer-ReviewedIn contrast to large GWA studies based on thousands of individuals and large meta-analyses combining GWAS results, we analyzed a small case/control sample for uric acid nephrolithiasis. Our cohort of closely related...
- 10From: PLoS Genetics. (Vol. 7, Issue 1) Peer-ReviewedNucleosomes in heterochromatic regions bear histone modifications that distinguish them from euchromatic nucleosomes. Among those, histone H3 lysine 9 methylation (H3K9me) and hypoacetylation have been evolutionarily...
- 11From: PLoS Genetics. (Vol. 7, Issue 1) Peer-ReviewedMetarhizium spp. are being used as environmentally friendly alternatives to chemical insecticides, as model systems for studying insect-fungus interactions, and as a resource of genes for biotechnology. We present a...
- 12From: PLoS Genetics. (Vol. 7, Issue 1) Peer-ReviewedIn somatic cells of female placental mammals, one of the two X chromosomes is transcriptionally silenced to accomplish an equal dose of X-encoded gene products in males and females. Initiation of random X chromosome...
- 13From: PLoS Genetics. (Vol. 7, Issue 1) Peer-ReviewedExpansions of trinucleotide GAA*TTC tracts are associated with the human disease Friedreich's ataxia, and long GAA*TTC tracts elevate genome instability in yeast. We show that tracts of [(GAA).sub.230]*[(TTC).sub.230]...
- 14From: PLoS Genetics. (Vol. 7, Issue 1) Peer-ReviewedCrohn's disease (CD) and celiac disease (CelD) are chronic intestinal inflammatory diseases, involving genetic and environmental factors in their pathogenesis. The two diseases can co-occur within families, and studies...
- 15From: PLoS Genetics. (Vol. 7, Issue 1) Peer-ReviewedPlacental mammals compensate the dosage imbalance of X-linked genes between males (XY) and females (XX) by silencing one randomly chosen X chromosome in females. This process is initiated during early embryonic...
- 16From: PLoS Genetics. (Vol. 7, Issue 1) Peer-ReviewedThe molecular mechanism for meiotic entry remains largely elusive in flowering plants. Only Arabidopsis SWI1/DYAD and maize AM1, both of which are the coiled-coil protein, are known to be required for the initiation of...
- 17From: PLoS Genetics. (Vol. 7, Issue 1) Peer-ReviewedRecent studies have established that the highly condensed and transcriptionally silent heterochromatic domains in budding yeast are virtually dynamic structures. The underlying mechanisms for heterochromatin dynamics,...
- 18From: PLoS Genetics. (Vol. 7, Issue 1) Peer-ReviewedHypoxia Inducible Factor-1 (HIF-1) is essential for mammalian development and is the principal transcription factor activated by low oxygen tensions. [HIF]-[alpha] subunit quantities and their associated activity are...
- 19From: PLoS Genetics. (Vol. 7, Issue 1) Peer-ReviewedNeisseria meningitidis is the primary causative agent of bacterial meningitis. The genome is rich in repetitive DNA and almost 2% is occupied by a diminutive transposon called the Correia element. Here we report a...
- 20From: PLoS Genetics. (Vol. 7, Issue 1) Peer-ReviewedThe phenotype produced by a given genotype can be strongly modulated by environmental conditions. Therefore, natural populations continuously adapt to environment heterogeneity to maintain optimal phenotypes. It...