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- 1From: Retrovirology. (Vol. 7) Peer-ReviewedBackground HIV-1 envelope diversity remains a significant challenge for the development of an efficacious vaccine. The evolutionary forces that shape the diversity of envelope are incompletely understood. HIV-1...
- 2From: Retrovirology. (Vol. 7) Peer-ReviewedBackground The p51 subunit of the HIV-1 reverse transcriptase (RT) p66/p51 heterodimer arises from proteolytic cleavage of the RT p66 subunit C-terminal ribonuclease H (RNH) domain during virus maturation. Our...
- 3From: Retrovirology. (Vol. 7) Peer-ReviewedBreast milk transmission remains a major mode of infant HIV acquisition, yet anatomic and immunologic forces shaping virus quasispecies in milk are not well characterized. In this study, phylogenic analysis of envelope...
- 4From: Retrovirology. (Vol. 7) Peer-ReviewedBackground The zinc-finger antiviral protein (ZAP) specifically inhibits the replication of certain viruses, including murine leukemia virus (MLV), by preventing the accumulation of viral mRNA in the cytoplasm. ZAP...
- 5From: Retrovirology. (Vol. 7) Peer-ReviewedBackground HIV reservoirs are rapidly established after infection, and the effect of HAART initiated very early during acute infection on HIV reservoirs remains poorly documented, particularly in tissue known to...
- 6From: Retrovirology. (Vol. 7) Peer-ReviewedBackground We previously described a potent recombinant HIV-1 neutralizing protein, sCD4-17b, composed of soluble CD4 attached via a flexible polypeptide linker to an SCFv of the 17b human monoclonal antibody...
- 7From: Retrovirology. (Vol. 7) Peer-ReviewedBackground The foamy virus Pol protein is translated independently from Gag using a separate mRNA. Thus, in contrast to orthoretroviruses no Gag-Pol precursor protein is synthesized. Only the integrase domain is...
- 8From: Retrovirology. (Vol. 7) Peer-ReviewedBackground The impact of the products of the pol gene, specifically, reverse transcriptase (RT) on HIV-1 replication, evolution, and acquisition of drug resistance has been thoroughly characterized for subtype B. For...
- 9From: Retrovirology. (Vol. 7) Peer-ReviewedBackground There have been no previous studies of the long-term survival and temporal changes in plasma viral load among HIV-2 infected subjects. Methods 133 HIV-2 infected and 158 HIV-uninfected subjects from...
- 10From: Retrovirology. (Vol. 7) Peer-ReviewedBackground Platelets are associated with HIV in the blood of infected individuals and might modulate viral dissemination, particularly if the virus is directly transmitted into the bloodstream. The C-type lectin...
- 11From: Retrovirology. (Vol. 7) Peer-ReviewedBackground Enveloped viruses including the simian immunodeficiency virus (SIV) replicating within host cells acquire host proteins upon egress from the host cells. A number of studies have catalogued such host...
- 12From: Retrovirology. (Vol. 7) Peer-ReviewedBackground The HIV pandemic disseminated globally from Central West Africa, beginning in the second half of the twentieth century. To elucidate the virologic origins of the pandemic, a cross-sectional study was...
- 13From: Retrovirology. (Vol. 7) Peer-ReviewedBackground The maturation inhibitor bevirimat (BVM) potently inhibits human immunodeficiency virus type 1 (HIV-1) replication by blocking capsid-spacer peptide 1 (CA-SP1) cleavage. Recent clinical trials demonstrated...
- 14From: Retrovirology. (Vol. 7) Peer-ReviewedRetroviral induced malignancies serve as ideal models to help us better understand the molecular mechanisms associated with the initiation and progression of leukemogenesis. Numerous retroviruses including AEV, FLV,...
- 15From: Retrovirology. (Vol. 7) Peer-ReviewedBackground During HIV infection and/or antiretroviral therapy (ART), monocytes and macrophages exhibit a wide range of dysfunctions which contribute significantly to HIV pathogenesis and therapy-associated...
- 16From: Retrovirology. (Vol. 7) Peer-ReviewedBackground The ability to efficiently and selectively target gene delivery vectors to specific cell types in vitro and in vivo remains one of the formidable challenges in gene therapy. We pursued two different...
- 17From: Retrovirology. (Vol. 7) Peer-ReviewedThe xenotropic/polytropic subgroup of mouse leukemia viruses (MLVs) all rely on the XPR1 receptor for entry, but these viruses vary in tropism, distribution among wild and laboratory mice, pathogenicity, strategies used...
- 18From: Retrovirology. (Vol. 7) Peer-ReviewedBackground Inter-subtype recombinants dominate the HIV epidemics in three geographical regions. To better understand the role of HIV recombinants in shaping the current HIV epidemic, we here present the results of a...
- 19From: Retrovirology. (Vol. 7) Peer-Reviewed
- 20From: Retrovirology. (Vol. 7) Peer-ReviewedBackground Using the FIV model, we reported previously that CD4.sup.+.sup.CD25.sup.+ .sup.T regulatory (Treg) cells from FIV.sup.+ .sup.cats are constitutively activated and suppress CD4.sup.+.sup.CD25.sup.- .sup.and...