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- 1From: PLoS Neglected Tropical Diseases. (Vol. 6, Issue 9) Peer-ReviewedBackground: Emergence of human fascioliasis prompted a worldwide control initiative including a pilot study in a few countries. Two hyperendemic areas were chosen: Huacullani, Northern Altiplano, Bolivia, representing...
- 2From: PLoS Neglected Tropical Diseases. (Vol. 6, Issue 9) Peer-ReviewedA Standardized Approach to Early-Phase, Proof-of-Concept Therapeutic Trials in Dengue This Perspective article reflects discussions held at the 1st International Dengue Therapeutics Workshop, held in Ho Chi Minh...
- 3From: PLoS Neglected Tropical Diseases. (Vol. 6, Issue 9) Peer-ReviewedEntamoeba histolytica, a microaerophilic enteric protozoan parasite, causes amebic colitis and extra intestinal abscesses in millions of inhabitants of endemic areas. Trophozoites of E. histolytica are exposed to a...
- 4From: PLoS Neglected Tropical Diseases. (Vol. 6, Issue 9) Peer-ReviewedA Schistosoma mansoni cercarial antigen preparation (cercarial transformation fluid--SmCTF) was evaluated for detection of anti-schistosome antibodies in human sera in 4 collaborating laboratories. The performance of...
- 5From: PLoS Neglected Tropical Diseases. (Vol. 6, Issue 9) Peer-ReviewedBackground: Each year millions of travelers visit Southeast Asia where rabies is still prevalent. This study aimed to assess the risk of rabies exposure, i.e., by being bitten or licked by an animal, among travelers in...
- 6From: PLoS Neglected Tropical Diseases. (Vol. 6, Issue 9) Peer-ReviewedBackground: After many years of neglect, schistosomiasis control is going to scale. The strategy of choice is preventive chemotherapy, that is the repeated large-scale administration of praziquantel (a safe and highly...
- 7From: PLoS Neglected Tropical Diseases. (Vol. 6, Issue 9) Peer-ReviewedBackground: In northern Ethiopia the prevalence of visceral leishmaniasis is steadily rising posing an increasing public health concern. In order to develop effective control strategies on the transmission of the...
- 8From: PLoS Neglected Tropical Diseases. (Vol. 6, Issue 9) Peer-ReviewedBackground: Studies have shown that a bacterial fibronectin attachment protein (FAP) is able to stimulate strong systemic and mucosal antibody responses when it is used alone or co-administrated with other antigens...
- 9From: PLoS Neglected Tropical Diseases. (Vol. 6, Issue 9) Peer-ReviewedBuruli or Bairnsdale Ulcer (BU) is a neglected infectious disease caused by Mycobacterium ulcerans and is characterized by necrotic cutaneous lesions. Infection is challenging to treat, and the ideal combination of...
- 10From: PLoS Neglected Tropical Diseases. (Vol. 6, Issue 9) Peer-ReviewedBackground: The presence in Morocco of Argasid ticks of the Ornithodoros erraticus complex, the vector of tick-borne relapsing fever (TBRF) in North Africa, has been known since 1919, but the disease is rarely diagnosed...
- 11From: PLoS Neglected Tropical Diseases. (Vol. 6, Issue 9) Peer-ReviewedBackground: Urogenital schistosomiasis is caused by the helminth parasite Schistosoma haematobium. In high transmission areas, children acquire schistosome infection early in life with infection levels peaking in early...
- 12From: PLoS Neglected Tropical Diseases. (Vol. 6, Issue 9) Peer-ReviewedBackground: Lassa fever is a viral hemorrhagic fever endemic in West Africa. However, none of the hospitals in the endemic areas of Nigeria has the capacity to perform Lassa virus diagnostics. Case identification and...
- 13From: PLoS Neglected Tropical Diseases. (Vol. 6, Issue 9) Peer-ReviewedBackground: Dengue is an emerging health problem in several coastlines along the Red Sea. The objective of the present work is to elucidate spatial and temporal patterns of dengue transmission in Port Sudan....
- 14From: PLoS Neglected Tropical Diseases. (Vol. 6, Issue 9) Peer-ReviewedBackground: Chemotherapy for leishmaniasis, a disease caused by Leishmania parasites, is expensive and causes side effects. Furthermore, parasite resistance constitutes an increasing problem, and new drugs against this...
- 15From: PLoS Neglected Tropical Diseases. (Vol. 6, Issue 9) Peer-ReviewedSchistosoma japonicum is endemic in the Philippines, China and Indonesia, and infects more than 40 mammalian host species, all of which can act as reservoirs of infection. In China, water buffaloes have been shown to be...
- 16From: PLoS Neglected Tropical Diseases. (Vol. 6, Issue 9) Peer-ReviewedBackground: Giardia duodenalis is a widespread intestinal protozoan of both humans and mammals. To date, few epidemiological studies have assessed the potential and importance of zoonotic transmission; and the human...
- 17From: PLoS Neglected Tropical Diseases. (Vol. 6, Issue 9) Peer-ReviewedBackground: The global distribution map of schistosomiasis shows a large overlap of Schistosoma haematobium- and S. mansoni-endemic areas in Africa. Yet, little is known about the consequences of mixed Schistosoma...
- 18From: PLoS Neglected Tropical Diseases. (Vol. 6, Issue 9) Peer-ReviewedBackground: Despite several leprosy control measures in Nigeria, child proportion and disability grade 2 cases remain high while new cases have not significantly reduced, suggesting continuous spread of the disease....
- 19From: PLoS Neglected Tropical Diseases. (Vol. 6, Issue 9) Peer-ReviewedThe incidence of dengue fever and dengue hemorrhagic fever in Brazil experienced a significant increase since the emergence of dengue virus type-3 (DENV-3) at the early 2000s. Despite the major public health concerns,...
- 20From: PLoS Neglected Tropical Diseases. (Vol. 6, Issue 9) Peer-ReviewedBackground: Genotype I (GI) Japanese encephalitis virus (JEV) that replaced GIII virus has become the dominant circulating virus in Asia. Currently, all registered live and inactivated JEV vaccines are derived from...