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- 1From: Nature Reviews Rheumatology. (Vol. 6, Issue 9) Peer-ReviewedSjogren's syndrome (SS), a chronic autoimmune disorder, particularly compromises the function of exocrine glands. The involvement of these glands is characterized by focal, mononuclear cell infiltrates that surround the...
- 2From: Nature Reviews Rheumatology. (Vol. 6, Issue 9) Peer-ReviewedThe role of body weight in the pathogenesis of osteoarthritis (OA)--previously considered the sole factor in the association between obesity and OA--is being re-evaluated as the contribution of adiposity to this process...
- 3From: Nature Reviews Rheumatology. (Vol. 6, Issue 9) Peer-ReviewedPatients with rheumatoid arthritis (RA) are known to be particularly susceptible to infection owing to systemic defects in type 1 T helper ([T.sub.H]1) signaling-characterized by decreased interferon (IFN)-[gamma]...
- 4From: Nature Reviews Rheumatology. (Vol. 6, Issue 9) Peer-ReviewedThe aim of treatment for patients with gout flares is the rapid cessation of pain and inflammation. Standard anti-inflammatory treatments, such as NSAIDs and corticosteroids, might not be effective in all patients, and...
- 5From: Nature Reviews Rheumatology. (Vol. 6, Issue 9) Peer-ReviewedPatients with systemic lupus erythematosus (SLE) often require pulsed intravenous glucocorticoid therapy if oral glucocorticoids fail to control their disease. why are doses of steroids that successfully control disease...
- 6From: Nature Reviews Rheumatology. (Vol. 6, Issue 9) Peer-ReviewedExercise is a recommended nonpharmacological intervention for individuals with fibromyalgia because exercise can improve physical function and well-being, and might also decrease pain. (1) Promoting exercise in the...
- 7From: Nature Reviews Rheumatology. (Vol. 6, Issue 9) Peer-ReviewedSeveral new targeted biologic agents for treating lupus nephritis are on the horizon; however, it is important to determine the circumstances in which they should be used, and how to optimally combine these agents with...
- 8From: Nature Reviews Rheumatology. (Vol. 6, Issue 9) Peer-ReviewedSystemic lupus erythematosus (SLE) is a chronic, multisystem autoimmune disease with a highly variable clinical course. Pediatric-onset SLE (pSLE) represents 10-20% of all SLE cases, and is associated with higher...
- 9From: Nature Reviews Rheumatology. (Vol. 6, Issue 9) Peer-ReviewedA key component of Paget disease of bone is a localized increase in osteoclastic activity, which might be attributable, in part, to mutations in the sequestosome 1 gene. a study has identified three new genes that...
- 10From: Nature Reviews Rheumatology. (Vol. 6, Issue 9) Peer-ReviewedGlucocorticoids are commonly used to treat patients with autoimmune diseases, but are known to induce osteoporosis. These agents are thought to reduce bone mass via induction of apoptosis and/or suppression of...
- 11From: Nature Reviews Rheumatology. (Vol. 6, Issue 9) Peer-ReviewedNatural killer (NK) cells contribute to the bone erosion characteristic of rheumatoid arthritis (RA) by inducing the differentiation of monocytes into osteoclasts, according to new research by Soderstrom et al....
- 12From: Nature Reviews Rheumatology. (Vol. 6, Issue 9) Peer-ReviewedPatients with osteoarthritis (OA) are known to benefit from regular moderate exercise and a new study published in Arthritis Research & Therapy suggests that an increase in the concentration of the anti-inflammatory...
- 13From: Nature Reviews Rheumatology. (Vol. 6, Issue 9) Peer-ReviewedGlucosamine and chondroitin sulphate, dietary supplements popular with individuals who have osteoarthritis (OA), have been shown to be no more efficacious than placebo or the NsAID celecoxib, according to the 2-year...
- 14From: Nature Reviews Rheumatology. (Vol. 6, Issue 9) Peer-ReviewedProinflammatory cytokines such as tumor necrosis factor (TNF) have long been known to have an important role in the pathogenesis of psoriasis, a chronic inflammatory immune-mediated disease. (1) Accordingly, agents that...
- 15From: Nature Reviews Rheumatology. (Vol. 6, Issue 9) Peer-ReviewedOsteoporosis is an important and complex disorder that is highly prevalent worldwide. This disease poses a major challenge to modern medicine and its treatment is associated with high costs. Numerous studies have...
- 16From: Nature Reviews Rheumatology. (Vol. 6, Issue 9) Peer-ReviewedBelimumab, a humanized antibody against B-cell-activating factor (BAFF, also known as BLyS and tumor necrosis factor ligand superfamily, member 13b) has been hailed as a promising new agent for the treatment of systemic...
- 17From: Nature Reviews Rheumatology. (Vol. 6, Issue 9) Peer-ReviewedArising with the concept of 'evidence-based medicine', the growth of treatment guidelines has been fueled by documentation of wide variations in clinical practice that are dissociated from any benefit in clinical...
- 18From: Nature Reviews Rheumatology. (Vol. 6, Issue 9) Peer-ReviewedHuman disorders of hereditary and nonhereditary heterotopic ossification are conditions in which osteogenesis occurs outside of the skeleton, within soft tissues of the body. The resulting extraskeletal bone is normal....