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Academic Journals
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- Search Terms:ISSN: 15537366AndISSN: 15537374AndVolume Number: 6AndIssue Number: 9AndStart Page: e1001090AndDate: 2010 Revise Search
- 1From: PLoS Pathogens. (Vol. 6, Issue 9) Peer-ReviewedToll-like receptor signaling requires functional ToN/interleukin-1 (IL-1) receptor (TIR) domains to activate innate immunity. By producing TIR homologous proteins, microbes inhibit host response induction and improve...
- 2From: PLoS Pathogens. (Vol. 6, Issue 9) Peer-ReviewedMany enteropathogenic bacteria target the mammalian gut. The mechanisms protecting the host from infection are poorly understood. We have studied the protective functions of secretory antibodies (sIgA) and the...
- 3From: PLoS Pathogens. (Vol. 6, Issue 9) Peer-ReviewedCoevolutionary interactions, such as those between host and parasite, predator and prey, or plant and pollinator, evolve subject to the genes of both interactors. It is clear, for example, that the evolution of...
- 4From: PLoS Pathogens. (Vol. 6, Issue 9) Peer-ReviewedHuman infections with subtype H7 avian influenza viruses have been reported as early as 1979. In 1996, a genetically stable 24-nucleotide deletion emerged in North American H7 influenza virus hemagglutinins, resulting...
- 5From: PLoS Pathogens. (Vol. 6, Issue 9) Peer-ReviewedThe high-risk HPV E6 and E7 proteins cooperate to immortalize primary human cervical cells and the E7 protein can independently transform fibroblasts in vitro, primarily due to its ability to associate with and degrade...
- 6From: PLoS Pathogens. (Vol. 6, Issue 9) Peer-Reviewed[CD8.sup.+] T cells can exert both protective and harmful effects on the virus-infected host. However, there is no systematic method to identify the attributes of a protective [CD8.sup.+] T cell response. Here, we...
- 7From: PLoS Pathogens. (Vol. 6, Issue 9) Peer-ReviewedApoptosis in HIV-1-infected CD4+ primary T cells is triggered by the alteration of the PI3K and p53 pathways, which converge on the FOXO3a transcriptional activator. Tat alone can cause activation of FOXO3a and of its...
- 8From: PLoS Pathogens. (Vol. 6, Issue 9) Peer-ReviewedAlthough there is tremendous interest in understanding the evolutionary roles of horizontal gene transfer (HGT) processes that occur during chronic polyclonal infections, to date there have been few studies that...
- 9From: PLoS Pathogens. (Vol. 6, Issue 9) Peer-ReviewedMetal hyperaccumulation, in which plants store exceptional concentrations of metals in their shoots, is an unusual trait whose evolutionary and ecological significance has prompted extensive debate. Hyperaccumulator...
- 10From: PLoS Pathogens. (Vol. 6, Issue 9) Peer-ReviewedViruses have evolved several strategies to modify cellular processes and evade the immune response in order to successfully infect, replicate, and persist in the host. By utilizing in-silico testing of a transmembrane...
- 11From: PLoS Pathogens. (Vol. 6, Issue 9) Peer-ReviewedThe onset of human cytomegalovirus (HCMV) lytic infection is strictly synchronized with the host cell cycle. Infected G0/ G1 cells support viral immediate early (IE) gene expression and proceed to the G1/S boundary...
- 12From: PLoS Pathogens. (Vol. 6, Issue 9) Peer-ReviewedPlasmodesmata (PD) are essential but poorly understood structures in plant cell walls that provide symplastic continuity and intercellular communication pathways between adjacent cells and thus play fundamental roles in...
- 13From: PLoS Pathogens. (Vol. 6, Issue 9) Peer-ReviewedThe mucosal immune system identifies and fights invading pathogens, while allowing non-pathogenic organisms to persist. Mechanisms of pathogen/non-pathogen discrimination are poorly understood, as is the contribution of...
- 14From: PLoS Pathogens. (Vol. 6, Issue 9) Peer-ReviewedThe human membrane cofactor protein (MCP, CD46) is a central component of the innate immune system. CD46 protects autologous cells from complement attack by binding to complement proteins C3b and C4b and serving as a...
- 15From: PLoS Pathogens. (Vol. 6, Issue 9) Peer-ReviewedArenaviridae synthesize viral mRNAs using short capped primers presumably acquired from cellular transcripts by a 'cap-snatching' mechanism. Here, we report the crystal structure and functional characterization of the...
- 16From: PLoS Pathogens. (Vol. 6, Issue 9) Peer-ReviewedMicrobial pathogens exploit the clathrin endocytic machinery to enter host cells. Vesicular stomatitis virus (VSV), an enveloped virus with bullet-shaped virions that measure 70x200 nm, enters cells by...
- 17From: PLoS Pathogens. (Vol. 6, Issue 9) Peer-ReviewedThe ability of the tubercle bacillus to arrest phagosome maturation is considered one major mechanism that allows its survival within host macrophages. To identify mycobacterial genes involved in this process, we...
- 18From: PLoS Pathogens. (Vol. 6, Issue 9) Peer-ReviewedDNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian gene regulation. In general, cytosine-phosphatidyl-guanosine (CpG)-methylated promoters are transcriptionally...
- 19From: PLoS Pathogens. (Vol. 6, Issue 9) Peer-ReviewedMany viruses alter expression of proteins on the surface of infected cells including molecules important for immune recognition, such as the major histocompatibility complex (MHC) class I and II molecules. Virus-induced...
- 20From: PLoS Pathogens. (Vol. 6, Issue 9) Peer-ReviewedAlthough polymicrobial infections, caused by combinations of viruses, bacteria, fungi and parasites, are being recognized with increasing frequency, little is known about the occurrence of within-species diversity in...