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- 1From: PLoS Computational Biology. (Vol. 6, Issue 9) Peer-ReviewedSubjects typically choose to be presented with stimuli that predict the existence of future reinforcements. This so-called 'observing behavior' is evident in many species under various experimental conditions, including...
- 2From: PLoS Computational Biology. (Vol. 6, Issue 9) Peer-ReviewedFly lobula plate tangential cells are known to perform wide-field motion integration. It is assumed that the shape of these neurons, and in particular the shape of the subclass of VS cells, is responsible for this type...
- 3From: PLoS Computational Biology. (Vol. 6, Issue 9) Peer-ReviewedA neural field model is presented that captures the essential non-linear characteristics of activity dynamics across several millimeters of visual cortex in response to local flashed and moving stimuli. We account for...
- 4From: PLoS Computational Biology. (Vol. 6, Issue 9) Peer-ReviewedDrug perturbations of human cells lead to complex responses upon target binding. One of the known mechanisms is a (positive or negative) feedback loop that adjusts the expression level of the respective target protein....
- 5From: PLoS Computational Biology. (Vol. 6, Issue 9) Peer-ReviewedRecent advances in structural bioinformatics have enabled the prediction of protein-drug off-targets based on their ligand binding sites. Concurrent developments in systems biology allow for prediction of the functional...
- 6From: PLoS Computational Biology. (Vol. 6, Issue 9) Peer-ReviewedContemporary theory of spiking neuronal networks is based on the linear response of the integrate-and-fire neuron model derived in the diffusion limit. We find that for non-zero synaptic weights, the response to...
- 7From: PLoS Computational Biology. (Vol. 6, Issue 9) Peer-ReviewedThe scientific literature represents a rich source for retrieval of knowledge on associations between biomedical concepts such as genes, diseases and cellular processes. A commonly used method to establish relationships...
- 8From: PLoS Computational Biology. (Vol. 6, Issue 9) Peer-ReviewedRecently developed atrophic non-union models are a good representation of the clinical situation in which many non-unions develop. Based on previous experimental studies with these atrophic non-union models, it was...
- 9From: PLoS Computational Biology. (Vol. 6, Issue 9) Peer-ReviewedMalaria epidemics in regions with seasonal windows of transmission can vary greatly in size from year to year. A central question has been whether these interannual cycles are driven by climate, are instead generated by...
- 10From: PLoS Computational Biology. (Vol. 6, Issue 9) Peer-ReviewedCatalysis of ADP-ATP exchange by nucleotide exchange factors (NEFs) is central to the activity of Hsp70 molecular chaperones. Yet, the mechanism of interaction of this family of chaperones with NEFs is not well...
- 11From: PLoS Computational Biology. (Vol. 6, Issue 9) Peer-ReviewedCollective decision making and especially leadership in groups are among the most studied topics in natural, social, and political sciences. Previous studies have shown that some individuals are more likely to be...
- 12From: PLoS Computational Biology. (Vol. 6, Issue 9) Peer-ReviewedProtein folding dynamics is often described as diffusion on a free energy surface considered as a function of one or few reaction coordinates. However, a growing number of experiments and models show that, when...
- 13From: PLoS Computational Biology. (Vol. 6, Issue 9) Peer-ReviewedExpanded polyglutamine (polyQ) proteins are known to be the causative agents of a number of human neurodegenerative diseases but the molecular basis of their cytoxicity is still poorly understood. PolyQ tracts may...
- 14From: PLoS Computational Biology. (Vol. 6, Issue 9) Peer-ReviewedMany zoonotic, novel infectious diseases in humans appear as sporadic infections with spatially and temporally restricted outbreaks, as seen with influenza A(H5N1). Adaptation is often a key factor for successfully...
- 15From: PLoS Computational Biology. (Vol. 6, Issue 9) Peer-ReviewedThe var gene encoded hyper-variable Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family mediates cytoadhesion of infected erythrocytes to human endothelium. Antibodies blocking cytoadhesion are...
- 16From: PLoS Computational Biology. (Vol. 6, Issue 9) Peer-ReviewedQuantitative models of cis-regulatory activity have the potential to improve our mechanistic understanding of transcriptional regulation. However, the few models available today have been based on simplistic assumptions...
- 17From: PLoS Computational Biology. (Vol. 6, Issue 9) Peer-ReviewedFast-spiking (FS) cells in the neocortex are interconnected both by inhibitory chemical synapses and by electrical synapses, or gap-junctions. Synchronized firing of FS neurons is important in the generation of gamma...
- 18From: PLoS Computational Biology. (Vol. 6, Issue 9) Peer-ReviewedWikipedia is the world's most successful online encyclopedia, now containing over 3.3 million English language articles. It is probably the largest collection of knowledge ever assembled, and is certainly the most...
- 19From: PLoS Computational Biology. (Vol. 6, Issue 9) Peer-Reviewed
Regression analysis for constraining free parameters in electrophysiological models of cardiac cells
A major challenge in computational biology is constraining free parameters in mathematical models. Adjusting a parameter to make a given model output more realistic sometimes has unexpected and undesirable effects on... - 20From: PLoS Computational Biology. (Vol. 6, Issue 9) Peer-ReviewedGenetic interactions occur when a combination of mutations results in a surprising phenotype. These interactions capture functional redundancy, and thus are important for predicting function, dissecting protein...