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Academic Journals
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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 6AndIssue Number: 8AndStart Page: e1001065AndDate: 2010 Revise Search
- 1From: PLoS Genetics. (Vol. 6, Issue 8) Peer-ReviewedSaccharomyces cerevisiae Rad9 is required for an effective DNA damage response throughout the cell cycle. Assembly of Rad9 on chromatin after DNA damage is promoted by histone modifications that create docking sites for...
- 2From: PLoS Genetics. (Vol. 6, Issue 8) Peer-ReviewedEukaryotic genomes are associated with a number of proteins such as histones that constitute chromatin. Post- translational histone modifications are associated with regulatory aspects executed by chromatin and all...
- 3From: PLoS Genetics. (Vol. 6, Issue 8) Peer-ReviewedThe Helicobacter pylori cag pathogenicity island (cagPAI) encodes a type IV secretion system. Humans infected with cagPAI--carrying H. pylori are at increased risk for sequelae such as gastric cancer. Housekeeping genes...
- 4From: PLoS Genetics. (Vol. 6, Issue 8) Peer-ReviewedTo form functional neuronal connections, axon outgrowth and guidance must be tightly regulated across space as well as time. While a number of genes and pathways have been shown to control spatial features of axon...
- 5From: PLoS Genetics. (Vol. 6, Issue 8) Peer-ReviewedDeleterious mutations appearing in a population increase in frequency until stopped by natural selection. The ensuing equilibrium creates a stable frequency of deleterious mutations or the mutational load. Here I...
- 6From: PLoS Genetics. (Vol. 6, Issue 8) Peer-ReviewedAccurate chromosome segregation during meiosis requires that homologous chromosomes pair and become physically connected so that they can orient properly on the meiosis I spindle. These connections are formed by...
- 7From: PLoS Genetics. (Vol. 6, Issue 8) Peer-ReviewedPseudogenes are usually considered to be completely neutral sequences whose evolution is shaped by random mutations and chance events. It is possible, however, for disrupted genes to generate products that are...
- 8From: PLoS Genetics. (Vol. 6, Issue 8) Peer-ReviewedMitochondrial dysfunction has been observed in skeletal muscle of people with diabetes and insulin-resistant individuals. Furthermore, inherited mutations in mitochondrial DNA can cause a rare form of diabetes. However,...
- 9From: PLoS Genetics. (Vol. 6, Issue 8) Peer-ReviewedMaintenance of telomere capping is absolutely essential to the survival of eukaryotic cells. Telomere capping proteins, such as Cdc13 and POT1, are essential for the viability of budding yeast and mammalian cells,...
- 10From: PLoS Genetics. (Vol. 6, Issue 8) Peer-ReviewedOne of the challenges to understand the organization of the nervous system has been to determine how axon guidance molecules govern axon outgrowth. Through an unbiased genetic screen, we identified a conserved Wnt...
- 11From: PLoS Genetics. (Vol. 6, Issue 8) Peer-ReviewedDuring meiosis, the Msh4-Msh5 complex is thought to stabilize single-end invasion intermediates that form during early stages of recombination and subsequently bind to Holliday junctions to facilitate crossover...
- 12From: PLoS Genetics. (Vol. 6, Issue 8) Peer-ReviewedThe differentiation of cells into distinct cell types, each of which is heritable for many generations, underlies many biological phenomena. White and opaque cells of the fungal pathogen Candida albicans are two such...
- 13From: PLoS Genetics. (Vol. 6, Issue 8) Peer-ReviewedCaenorhabditis elegans SKN-1 (ortholog of mammalian Nrf1/2/3) is critical for oxidative stress resistance and promotes longevity under reduced insulin/IGF-1-like signaling (IIS), dietary restriction (DR), and normal...
- 14From: PLoS Genetics. (Vol. 6, Issue 8) Peer-ReviewedMechanisms underlying the dramatic patterns of genome size variation across the tree of life remain mysterious. Effective population size ([N.sub.e]) has been proposed as a major driver of genome size: selection is...
- 15From: PLoS Genetics. (Vol. 6, Issue 8) Peer-ReviewedRecent reports of strong selection of mitochondrial DNA (mtDNA) during transmission in animal models of mtDNA disease, and of nuclear transfer in both animal models and humans, have important scientific implications....
- 16From: PLoS Genetics. (Vol. 6, Issue 8) Peer-ReviewedThe large conductance, voltage- and calcium-dependent potassium (BK) channel serves as a major negative feedback regulator of calcium-mediated physiological processes and has been implicated in muscle dysfunction and...
- 17From: PLoS Genetics. (Vol. 6, Issue 8) Peer-ReviewedHeterozygous mutations in p63 are associated with split hand/foot malformations (SHFM), orofacial clefting, and ectodermal abnormalities. Elucidation of the p63 gene network that includes target genes and regulatory...
- 18From: PLoS Genetics. (Vol. 6, Issue 8) Peer-ReviewedCrossovers mediate the accurate segregation of homologous chromosomes during meiosis. The widely conserved pch2 gene of Drosophila melanogaster is required for a pachytene checkpoint that delays prophase progression...
- 19From: PLoS Genetics. (Vol. 6, Issue 8) Peer-ReviewedAlthough of fundamental importance in developmental biology, the genetic basis for the symmetry breaking events that polarize the vertebrate oocyte and egg are largely unknown. In vertebrates, the first morphological...
- 20From: PLoS Genetics. (Vol. 6, Issue 8) Peer-ReviewedGenome-wide association studies of lung cancer reported in populations of European background have identified three regions on chromosomes 5p15.33, 6p21.33, and 15q25 that have achieved genome-wide significance with...