Showing Results for
- Academic Journals (49)
Search Results
- 49
Academic Journals
- 49
- Search Terms:ISSN: 15537366AndISSN: 15537374AndVolume Number: 6AndIssue Number: 8AndStart Page: e1001028AndDate: 2010 Revise Search
- 1From: PLoS Pathogens. (Vol. 6, Issue 8) Peer-ReviewedResistance of viruses to mutagenic agents is an important problem for the development of lethal mutagenesis as an antiviral strategy. Previous studies with RNA viruses have documented that resistance to the mutagenic...
- 2From: PLoS Pathogens. (Vol. 6, Issue 8) Peer-ReviewedUpon infection of mammalian cells, enterohemorrhagic E. coli (EHEC) O157:H7 utilizes a type III secretion system to translocate the effectors Tir and Esp[F.sub.U] (aka TccP) that trigger the formation of F-actin-rich...
- 3From: PLoS Pathogens. (Vol. 6, Issue 8) Peer-ReviewedUNC93B1 associates with Toll-Like Receptor (TLR) 3, TLR7 and TLR9, mediating their translocation from the endoplasmic reticulum to the endolysosome, hence allowing proper activation by nucleic acid ligands. We found...
- 4From: PLoS Pathogens. (Vol. 6, Issue 8) Peer-ReviewedHBGAs Are an Important Factor in Norovirus Evolution Noroviruses, an important cause of acute gastroenteritis in humans, have been found to recognize the histo-blood group antigens (HBGAs) as receptors. Different...
- 5From: PLoS Pathogens. (Vol. 6, Issue 8) Peer-ReviewedChronic infections are an increasing problem due to the aging population and the increase in antibiotic resistant organisms. Therefore, understanding the host-pathogen interactions that result in chronic infection is of...
- 6From: PLoS Pathogens. (Vol. 6, Issue 8) Peer-Reviewed
Functional characterisation and drug target validation of a mitotic kinesin-13 in Trypanosoma brucei
Mitotic kinesins are essential for faithful chromosome segregation and cell proliferation. Therefore, in humans, kinesin motor proteins have been identified as anti-cancer drug targets and small molecule inhibitors are... - 7From: PLoS Pathogens. (Vol. 6, Issue 8) Peer-ReviewedIn contrast to HIV infection in humans and SIV in macaques, SIV infection of natural hosts including sooty mangabeys (SM) is non-pathogenic despite robust virus replication. We identified a novel SM CCR5 allele...
- 8From: PLoS Pathogens. (Vol. 6, Issue 8) Peer-ReviewedOnce the genome sequence of an organism is obtained, attention turns from identifying genes to understanding their function, their organization and control of metabolic pathways and networks that determine its...
- 9From: PLoS Pathogens. (Vol. 6, Issue 8) Peer-ReviewedKaposi's sarcoma (KS) is the most common cancer among HIV-positive patients. Histogenetic origin of KS has long been elusive due to a mixed expression of both blood and lymphatic endothelial markers in KS tumor cells....
- 10From: PLoS Pathogens. (Vol. 6, Issue 8) Peer-ReviewedTrans-splicing of leader sequences onto the 5'ends of mRNAs is a widespread phenomenon in protozoa, nematodes and some chordates. Using parallel sequencing we have developed a method to simultaneously map 5'splice sites...
- 11From: PLoS Pathogens. (Vol. 6, Issue 8) Peer-ReviewedBacterial pathogens causing systemic disease commonly evolve from organisms associated with localized infections but differ from their close relatives in their ability to overcome mucosal barriers by mechanisms that...
- 12From: PLoS Pathogens. (Vol. 6, Issue 8) Peer-ReviewedAlthough T cells are critical for host defense against respiratory fungal infections, they also contribute to the immunopathogenesis of Pneumocystis pneumonia (PcP). However, the precise downstream effector mechanisms...
- 13From: PLoS Pathogens. (Vol. 6, Issue 8) Peer-ReviewedIn the phytopathogenic basidiomycete Ustilago maydis, sexual and pathogenic development are tightly connected and controlled by the heterodimeric bE/bW transcription factor complex encoded by the b-mating type locus....
- 14From: PLoS Pathogens. (Vol. 6, Issue 8) Peer-ReviewedFungal pathogens exploit diverse mechanisms to survive exposure to antifungal drugs. This poses concern given the limited number of clinically useful antifungals and the growing population of immunocompromised...
- 15From: PLoS Pathogens. (Vol. 6, Issue 8) Peer-ReviewedViral replication efficiency is in large part governed by the ability of viruses to counteract pro-apoptotic signals induced by infection of the host cell. Human herpesvirus 8 (HHV-8) uses several strategies to block...
- 16From: PLoS Pathogens. (Vol. 6, Issue 8) Peer-ReviewedThree closely related bacterial species within the genus Neisseria are of importance to human disease and health. Neisseria meningitidis is a major cause of meningitis, while Neisseria gonorrhoeae is the agent of the...
- 17From: PLoS Pathogens. (Vol. 6, Issue 8) Peer-ReviewedIn this essay, I argue that unraveling the full genetic architecture (i.e., the number, position, effect, and interactions among genes underlying phenotypic variation) and molecular landscape of host-pathogen...
- 18From: PLoS Pathogens. (Vol. 6, Issue 8) Peer-ReviewedHIV-1 is present in anatomical compartments and bodily fluids. Most transmissions occur through sexual acts, making virus in semen the proximal source in male donors. We find three distinct relationships in comparing...
- 19From: PLoS Pathogens. (Vol. 6, Issue 8) Peer-ReviewedThe development of classically activated monocytic cells (Ml) is a prerequisite for effective elimination of parasites, including African trypanosomes. However, persistent activation of Ml that produce pathogenic...
- 20From: PLoS Pathogens. (Vol. 6, Issue 8) Peer-ReviewedHypervirulent strains of Clostridium difficile have emerged over the past decade, increasing the morbidity and mortality of patients infected by this opportunistic pathogen. Recent work suggested the major C. difficile...