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- 1From: PLoS Genetics. (Vol. 6, Issue 7) Peer-ReviewedWe hypothesized that variants in genes expressed as a consequence of interactions between ovarian cancer cells and the host micro-environment could contribute to cancer susceptibility. We therefore used a two-stage...
- 2From: PLoS Genetics. (Vol. 6, Issue 7) Peer-ReviewedWe used an approach that we term ancestry-shift refinement mapping to investigate an association, originally discovered in a GWAS of a Chinese population, between rs2046210[T] and breast cancer susceptibility. The locus...
- 3From: PLoS Genetics. (Vol. 6, Issue 7) Peer-ReviewedSex-specific traits that lead to the production of dimorphic gametes, sperm in males and eggs in females, are fundamental for sexual reproduction and accordingly widespread among animals. Yet the sex-biased genes that...
- 4From: PLoS Genetics. (Vol. 6, Issue 7) Peer-ReviewedCalcium has a pivotal role in biological functions, and serum calcium levels have been associated with numerous disorders of bone and mineral metabolism, as well as with cardiovascular mortality. Here we report results...
- 5From: PLoS Genetics. (Vol. 6, Issue 7) Peer-ReviewedDictyostelium discoideum is a eukaryotic microbial model system for multicellular development, cell-cell signaling, and social behavior. Key models of social evolution require an understanding of genetic relationships...
- 6From: PLoS Genetics. (Vol. 6, Issue 7) Peer-ReviewedChronic kidney disease (CKD) is a worldwide public health problem that is associated with substantial morbidity and mortality. To search for sequence variants that associate with CKD, we conducted a genome-wide...
- 7From: PLoS Genetics. (Vol. 6, Issue 7) Peer-ReviewedExpansion of the lysosomal system, including cathepsin D upregulation, is an early and prominent finding in Alzheimer's disease brain. Cell culture studies, however, have provided differing perspectives on the lysosomal...
- 8From: PLoS Genetics. (Vol. 6, Issue 7) Peer-ReviewedCitation: Gitschier J (2010) Question and Answer: An Anniversary Interview with Jane Gitschier. PLoS Genet 6(7): e1001018. doi: 10.1371/journal.pgen.1001018 Introduction by Gregory P. Copenhaver Important...
- 9From: PLoS Genetics. (Vol. 6, Issue 7) Peer-ReviewedDNA double-strand breaks are repaired by multiple mechanisms that are roughly grouped into the categories of homology-directed repair and non-homologous end joining. End-joining repair can be further classified as...
- 10From: PLoS Genetics. (Vol. 6, Issue 7) Peer-ReviewedAs a field of study, genomic imprinting has grown rapidly in the last 20 years, with a growing figure of around 100 imprinted genes known in the mouse and approximately 50 in the human. The imprinted expression of genes...
- 11From: PLoS Genetics. (Vol. 6, Issue 7) Peer-ReviewedIn meiosis, programmed DNA breaks repaired by homologous recombination (HR) can be processed into inter-homolog crossovers that promote the accurate segregation of chromosomes. In general, more programmed DNA...
- 12From: PLoS Genetics. (Vol. 6, Issue 7) Peer-ReviewedLYST is a large cytosolic protein that influences the biogenesis of lysosome-related organelles, and mutation of the encoding gene, LYST, can cause Chediak-Higashi syndrome. Recently, Lyst-mutant mice were recognized to...
- 13From: PLoS Genetics. (Vol. 6, Issue 7) Peer-ReviewedAlthough tumor size and lymph node involvement are the current cornerstones of breast cancer prognosis, they have not been extensively explored in relation to tumor methylation attributes in conjunction with other tumor...
- 14From: PLoS Genetics. (Vol. 6, Issue 7) Peer-ReviewedA central goal of developmental biology is to understand the mechanisms whereby undifferentiated, pluripotent cells differentiate into mature, organized cells and tissues. Recent advances in mouse genetics, embryonic...
- 15From: PLoS Genetics. (Vol. 6, Issue 7) Peer-ReviewedSchizosaccharomyces pombe Rad3 checkpoint kinase and its human ortholog ATR are essential for maintaining genome integrity in cells treated with genotoxins that damage DNA or arrest replication forks. Rad3 and ATR also...
- 16From: PLoS Genetics. (Vol. 6, Issue 7) Peer-ReviewedDNA double-strand breaks (DSBs) can be repaired by homologous recombination (HR), which can involve Holliday junction (HJ) intermediates that are ultimately resolved by nucleolytic enzymes. An N-terminal fragment of...
- 17From: PLoS Genetics. (Vol. 6, Issue 7) Peer-ReviewedThe Dobzhansky-Muller (D-M) model of speciation by genic incompatibility is widely accepted as the primary cause of interspecific postzygotic isolation. Since the introduction of this model, there have been theoretical...
- 18From: PLoS Genetics. (Vol. 6, Issue 7) Peer-ReviewedDespite the central role of estrogen exposure in breast and endometrial cancer development and numerous studies of genes in the estrogen metabolic pathway, polymorphisms within the pathway have not been consistently...
- 19From: PLoS Genetics. (Vol. 6, Issue 7) Peer-ReviewedCHD7 is one of nine members of the chromodomain helicase DNA-binding domain family of ATP-dependent chromatin remodeling enzymes found in mammalian cells. De novo mutation of CHD7 is a major cause of CHARGE syndrome, a...
- 20From: PLoS Genetics. (Vol. 6, Issue 7) Peer-Reviewed
Microevolution of Helicobacter pylori during prolonged infection of single hosts and within families
Our understanding of basic evolutionary processes in bacteria is still very limited. For example, multiple recent dating estimates are based on a universal inter-species molecular clock rate, but that rate was...