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- 1From: PLoS Pathogens. (Vol. 6, Issue 7) Peer-ReviewedBats are reservoirs for a wide range of zoonotic agents including lyssa-, henipah-, SARS-like corona-, Marburg-, Ebola-, and astroviruses. In an effort to survey for the presence of other infectious agents, known and...
- 2From: PLoS Pathogens. (Vol. 6, Issue 7) Peer-ReviewedBiological signaling processes may be mediated by complex networks in which network components and network sectors interact with each other in complex ways. Studies of complex networks benefit from approaches in which...
- 3From: PLoS Pathogens. (Vol. 6, Issue 7) Peer-ReviewedSalmonella enterica serovar Typhimurium is a common food-borne pathogen that induces inflammatory diarrhea and invades intestinal epithelial cells using a type three secretion system (T3SS) encoded within Salmonella...
- 4From: PLoS Pathogens. (Vol. 6, Issue 7) Peer-ReviewedInfluenza viruses elude immune responses and antiviral chemotherapeutics through genetic drift and reassortment. As a result, the development of new strategies that attack a highly conserved viral function to prevent...
- 5From: PLoS Pathogens. (Vol. 6, Issue 7) Peer-ReviewedA large number of medically important viruses, including HIV, hepatitis C virus, and influenza, have RNA genomes. These viruses replicate with extremely high mutation rates and exhibit significant genetic diversity....
- 6From: PLoS Pathogens. (Vol. 6, Issue 7) Peer-ReviewedSince the concentration of free iron in the human host is low, efficient iron-acquisition mechanisms constitute important virulence factors for pathogenic bacteria. In Gram-negative bacteria, TonB-dependent outer...
- 7From: PLoS Pathogens. (Vol. 6, Issue 7) Peer-ReviewedThe neuraminidase (NA) inhibitor oseltamivir offers an important immediate option for the control of influenza, and its clinical use has increased substantially during the recent H1N1 pandemic. In view of the high...
- 8From: PLoS Pathogens. (Vol. 6, Issue 7) Peer-ReviewedBacterial growth in multicellular communities, or biofilms, offers many potential advantages over single-cell growth, including resistance to antimicrobial factors. Here we describe the interaction between the...
- 9From: PLoS Pathogens. (Vol. 6, Issue 7) Peer-ReviewedThe Polyomaviridae constitute a family of small DNA viruses infecting a variety of hosts. In humans, polyomaviruses can cause infections of the central nervous system, urinary tract, skin, and possibly the respiratory...
- 10From: PLoS Pathogens. (Vol. 6, Issue 7) Peer-Reviewed[CD4.sup.+] T cell loss is central to HIV pathogenesis. In the initial weeks post-infection, the great majority of dying cells are uninfected [CD4.sup.+] T cells. We previously showed that the 3S motif of HIV-1 gp41...
- 11From: PLoS Pathogens. (Vol. 6, Issue 7) Peer-ReviewedSequence analysis of the genome of the strict intracellular pathogen Chlamydia trachomatis revealed the presence of a SET domain containing protein, proteins that primarily function as histone methyltransferases. In...
- 12From: PLoS Pathogens. (Vol. 6, Issue 7) Peer-ReviewedComplement forms an important arm of innate immunity against invasive meningococcal infections. Binding of the alternative complement pathway inhibitor factor H (fH) to fH-binding protein (fHbp) is one mechanism...
- 13From: PLoS Pathogens. (Vol. 6, Issue 7) Peer-ReviewedEpigenetic modifications of the herpesviral genome play a key role in the transcriptional control of latent and lytic genes during a productive viral lifecycle. In this study, we describe for the first time a...
- 14From: PLoS Pathogens. (Vol. 6, Issue 7) Peer-ReviewedViral infection of the central nervous system (CNS) poses unique challenges to the immune system with regards to controlling and eliminating the invading pathogen. These obstacles include the presence of a blood-brain...
- 15From: PLoS Pathogens. (Vol. 6, Issue 7) Peer-ReviewedReovirus infection leads to apoptosis in both cultured cells and the murine central nervous system (CNS). NF-[kappa]B- driven transcription of proapoptotic cellular genes is required for the effector phase of the...
- 16From: PLoS Pathogens. (Vol. 6, Issue 7) Peer-ReviewedUpon viral infection, the mitochondrial antiviral signaling (MAVS)-IKK[beta] pathway is activated to restrict viral replication. Manipulation of immune signaling events by pathogens has been an outstanding theme of...
- 17From: PLoS Pathogens. (Vol. 6, Issue 7) Peer-ReviewedHepatitis C Virus (HCV) is a major public health concern, with no effective vaccines currently available and 3% of the world's population being infected. Despite the existence of both B- and T-cell immunity in...
- 18From: PLoS Pathogens. (Vol. 6, Issue 7) Peer-ReviewedMany species of arthropod are infected by deleterious inherited micro-organisms. Typically these micro-organisms are inherited maternally. Consequently, some, particularly bacteria of the genus Wolbachia, employ a...
- 19From: PLoS Pathogens. (Vol. 6, Issue 7) Peer-ReviewedAs with many viruses, rabies virus (RABV) infection induces type I interferon (IFN) production within the infected host cells. However, RABV has evolved mechanisms by which to inhibit IFN production in order to sustain...
- 20From: PLoS Pathogens. (Vol. 6, Issue 7) Peer-ReviewedRadiation-attenuated Plasmodium sporozoites (RAS) are the only vaccine shown to induce sterilizing protection against malaria in both humans and rodents. Importantly, these "whole-parasite" vaccines are currently under...