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- 1From: Nature Methods. (Vol. 6, Issue 7) Peer-ReviewedWang et al. describe the synthesis of quantum dots that exhibit continuous photoluminescence. Other groups have developed various strategies to suppress blinking, but none have completely eliminated blinking. Wang et al....
- 2From: Nature Methods. (Vol. 6, Issue 7) Peer-ReviewedMicro-optics are increasingly used for minimally invasive in vivo imaging, in miniaturized microscopes and in lab-on-a-chip devices. Owing to optical aberrations and lower numerical apertures, a main class of microlens,...
- 3From: Nature Methods. (Vol. 6, Issue 7) Peer-ReviewedAn engineered infrared fluorescent protein is the first member of a new class of genetically encodable probes, with special advantages over visible-wavelength fluorescent proteins for in vivo imaging. Fluorescent...
- 4From: Nature Methods. (Vol. 6, Issue 7) Peer-ReviewedCompany Web address 454 Life Sciences, a Roche http://www.454.com/ company Affymetrix http://www.affymetrix.com/ Agencourt Bioscience http://www.agencourt.com/ Corporation Agitent Technologies http://www.agitent.com/...
- 5From: Nature Methods. (Vol. 6, Issue 7) Peer-ReviewedTo the Editor: High-throughput sequencing (HTS) has proven to be an invaluable tool for the discovery of thousands of microRNA genes across multiple species (1,2). At present, the throughput of HTS platforms is...
- 6From: Nature Methods. (Vol. 6, Issue 7) Peer-ReviewedOptical signatures from organic chemicals may help scientists detect traces of life on other planets. Until somebody finally gets around to inventing warp drive, the search for life outside our solar system will...
- 7From: Nature Methods. (Vol. 6, Issue 7) Peer-ReviewedGrafting two transgenic plants triggers lateral gene transfer at the graft site but does not elicit long-distance transport of DNA into the scion or root of the graft. Initially Ralph Bock's ambition was not to develop...
- 8From: Nature Methods. (Vol. 6, Issue 7) Peer-ReviewedTo the Editor: Human genetic variation comes in a wide range of sizes, from single-nucleotide polymorphisms and very small insertions and deletions (indels) to 'structural' variants, in which large segments of the genome...
- 9From: Nature Methods. (Vol. 6, Issue 7) Peer-ReviewedThe creation of unnatural but functional DNA base pairs has been a Long-standing goal in chemical biology. Several unnatural base pairs have been developed and tested in vitro, where they have been accepted by DNA...
- 10From: Nature Methods. (Vol. 6, Issue 7) Peer-ReviewedThe direct detection of antigen-specific T cells using tetramers of soluble peptide--major histocompatibilty complex (pMHC) molecules is widely used in both basic and clinical immunology. However, the number of...
- 11From: Nature Methods. (Vol. 6, Issue 7) Peer-ReviewedThe [CD8.sup.+] cytotoxic T lymphocyte (CTL) response functions primarily to eliminate viruses and some bacteria, parasites and tumors. CTLs use on the order of 25 million different T cell receptors (TCRs) to recognize a...
- 12From: Nature Methods. (Vol. 6, Issue 7) Peer-ReviewedTo the Editor: RNA interference (RNAi) is a popular functional genomic technology for identifying genes involved in a biological process. Although higher scores for genes in an RNAi screen suggest more central roles in...
- 13From: Nature Methods. (Vol. 6, Issue 7) Peer-ReviewedBiomolecules are highly pressure-sensitive, but their dynamics upon return to ambient pressure are often too fast to observe with existing approaches. We describe a sample-efficient method capable of large and very fast...
- 14From: Nature Methods. (Vol. 6, Issue 7) Peer-ReviewedWe report the characterization of a highly germline competent C57BL/6N mouse embryonic stem cell line, JM8. To simplify breeding schemes, the dominant agouti coat color gene was restored in JM8 cells by targeted repair...
- 15From: Nature Methods. (Vol. 6, Issue 7) Peer-ReviewedIn current multiplexing strategies for high-throughput sequencing, a molecular barcode is appended to each sample, allowing the parallel analysis of dozens of specimens. Erlich et al. now expand this multiplexing...
- 16From: Nature Methods. (Vol. 6, Issue 7) Peer-ReviewedTwo groups report culture conditions for long-term in vitro growth of intestinal tissue from the mouse. The surface of the mammalian intestine renews itself very rapidly, needing only about five days for complete...
- 17From: Nature Methods. (Vol. 6, Issue 7) Peer-ReviewedIn May 2009 Applied Biosystems, a division of Life Technologies, announced the sequencing of an entire human genome at 17-fold coverage, 50 billion mappable bases, all from a single run on the company's SOLID 3...
- 18From: Nature Methods. (Vol. 6, Issue 7) Peer-ReviewedWe developed a quantitative PCR method featuring a reusable single-cell cDNA library immobilized on beads for measuring the expression of multiple genes in a single cell. We used this method to analyze multiple cDNA...
- 19From: Nature Methods. (Vol. 6, Issue 7) Peer-ReviewedTo the Editor: Currently, the most widely used method for purifying recombinant proteins for biochemical and especially structural studies is immobilized metal affinity chromatography (IMAC), in which a metal-binding...
- 20From: Nature Methods. (Vol. 6, Issue 7) Peer-ReviewedOur view of protein folding, the process by which polypeptide chains self-assemble into specific three-dimensional structures, has gone hand in hand with the resolution of the available experimental techniques. For a...