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Academic Journals
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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 6AndIssue Number: 6AndStart Page: e1000990AndDate: 2010 Revise Search
- 1From: PLoS Genetics. (Vol. 6, Issue 8) Peer-ReviewedSaccharomyces cerevisiae Rad9 is required for an effective DNA damage response throughout the cell cycle. Assembly of Rad9 on chromatin after DNA damage is promoted by histone modifications that create docking sites for...
- 2From: PLoS Genetics. (Vol. 6, Issue 9) Peer-ReviewedHigh-altitude hypoxia (reduced inspired oxygen tension due to decreased barometric pressure) exerts severe physiological stress on the human body. Two high-altitude regions where humans have lived for millennia are the...
- 3From: PLoS Genetics. (Vol. 6, Issue 5) Peer-ReviewedThe radically distinct morphologies of arthropod and tetrapod legs argue that these appendages do not share a common evolutionary origin. Yet, despite dramatic differences in morphology, it has been known for some time...
- 4From: PLoS Genetics. (Vol. 6, Issue 1) Peer-ReviewedStress-induced transposition is an attractive notion since it is potentially important in creating diversity to facilitate adaptation of the host to severe environmental conditions. One common major stress is...
- 5From: PLoS Genetics. (Vol. 6, Issue 7) Peer-ReviewedWe hypothesized that variants in genes expressed as a consequence of interactions between ovarian cancer cells and the host micro-environment could contribute to cancer susceptibility. We therefore used a two-stage...
- 6From: PLoS Genetics. (Vol. 6, Issue 8) Peer-ReviewedEukaryotic genomes are associated with a number of proteins such as histones that constitute chromatin. Post- translational histone modifications are associated with regulatory aspects executed by chromatin and all...
- 7From: PLoS Genetics. (Vol. 6, Issue 2) Peer-ReviewedMulticellular animals match costly activities, such as growth and reproduction, to the environment through nutrient-sensing pathways. The insulin/IGF signaling (IIS) pathway plays key roles in growth, metabolism, stress...
- 8From: PLoS Genetics. (Vol. 6, Issue 3) Peer-ReviewedAlternative splicing controls the expression of many genes, including the Drosophila sex determination gene Sex-lethal (Sxl). Sxl expression is controlled via a negative regulatory mechanism where inclusion of the...
- 9From: PLoS Genetics. (Vol. 6, Issue 4) Peer-ReviewedFragile X syndrome (FXS), the most common form of inherited mental retardation, is caused by the loss of functional fragile X mental retardation protein (FMRP). FMRP is an RNA-binding protein that can regulate the...
- 10From: PLoS Genetics. (Vol. 6, Issue 4) Peer-ReviewedGene duplication is a major mechanism facilitating adaptation to changing environments. From recent genomic analyses, the acquisition of zinc hypertolerance and hyperaccumulation characters discriminating Arabidopsis...
- 11From: PLoS Genetics. (Vol. 6, Issue 1) Peer-ReviewedThe genetic basis of morphological differences among species is still poorly understood. We investigated the genetic basis of sex-specific differences in wing size between two closely related species of Nasonia by...
- 12From: PLoS Genetics. (Vol. 6, Issue 8) Peer-ReviewedThe Helicobacter pylori cag pathogenicity island (cagPAI) encodes a type IV secretion system. Humans infected with cagPAI--carrying H. pylori are at increased risk for sequelae such as gastric cancer. Housekeeping genes...
- 13From: PLoS Genetics. (Vol. 6, Issue 5) Peer-ReviewedThe plant life cycle alternates between two distinct multi-cellular generations, the reduced gametophytes and the dominant sporophyte. Little is known about how generation-specific cell fate, differentiation, and...
- 14From: PLoS Genetics. (Vol. 6, Issue 7) Peer-ReviewedWe used an approach that we term ancestry-shift refinement mapping to investigate an association, originally discovered in a GWAS of a Chinese population, between rs2046210[T] and breast cancer susceptibility. The locus...
- 15From: PLoS Genetics. (Vol. 6, Issue 2) Peer-ReviewedThe natural transfer of DNA from mitochondria to the nucleus generates nuclear copies of mitochondrial DNA (numts) and is an ongoing evolutionary process, as genome sequences attest. In humans, five different numts...
- 16From: PLoS Genetics. (Vol. 6, Issue 9) Peer-ReviewedReplication Protein A (RPA) is a heterotrimeric, single-stranded DNA (ssDNA)-binding complex required for DNA replication and repair, homologous recombination, DNA damage checkpoint signaling, and telomere maintenance....
- 17From: PLoS Genetics. (Vol. 6, Issue 9) Peer-ReviewedAging is a complex phenotype responsive to a plethora of environmental inputs; yet only a limited number of transcriptional regulators are known to influence life span. How the downstream expression programs mediated by...
- 18From: PLoS Genetics. (Vol. 6, Issue 9) Peer-ReviewedChromosome missegregation in germ cells is an important cause of unexplained infertility, miscarriages, and congenital birth defects in humans. However, the molecular defects that lead to production of aneuploid gametes...
- 19From: PLoS Genetics. (Vol. 6, Issue 9) Peer-ReviewedTo ensure genomic integrity, the genome must be duplicated exactly once per cell cycle. Disruption of replication licensing mechanisms may lead to re-replication and genomic instability. Cdt1, also known as...
- 20From: PLoS Genetics. (Vol. 6, Issue 11) Peer-ReviewedGene expression responds to changes in conditions but also stochastically among individuals. In budding yeast, both expression responsiveness across conditions ("plasticity") and cell-to-cell variation ("noise") have...