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- 1From: Nature Reviews Molecular Cell Biology. (Vol. 6, Issue 6) Peer-ReviewedAuthor(s): Arianne Heinrichs Replicated chromosomes bind to the mitotic spindle through specialized structures -- kinetochores -- that assemble on centromeres. Kinetochores must be captured by spindle microtubules and...
- 2From: Nature Reviews Molecular Cell Biology. (Vol. 6, Issue 6) Peer-ReviewedAuthor(s): Shannon Amoils Atherosclerosis causes significant mortality and morbidity in the Western World, and the prevention of this disorder is therefore an urgent healthcare priority. Now, a new report in...
- 3From: Nature Reviews Molecular Cell Biology. (Vol. 6, Issue 6) Peer-ReviewedAuthor(s): Volker Gerke (corresponding author) [1]; Carl E. Creutz [2]; Stephen E. Moss [3] Ca2+ signalling has a pivotal role in the regulation of many cellular processes in all eukaryotic organisms. Proteins that are...
- 4From: Nature Reviews Molecular Cell Biology. (Vol. 6, Issue 6) Peer-ReviewedAutophagy is an evolutionarily conserved mechanism for the degradation of cellular components in the cytoplasm, and serves as a cell survival mechanism in starving cells. Recent studies indicate that autophagy also...
- 5From: Nature Reviews Molecular Cell Biology. (Vol. 6, Issue 6) Peer-ReviewedCells require a constant supply of macromolecular precursors and oxidizable substrates to maintain viability. Unicellular eukaryotes lack the ability to regulate nutrient concentrations in their extracellular...
- 6From: Nature Reviews Molecular Cell Biology. (Vol. 6, Issue 6) Peer-ReviewedAuthor(s): Katrin Bussell Mammals have skin; insects have cuticle -- both function as barriers. It goes without saying that simple wounds in these integuments must be fixed, and William McGinnis' group have defined...
- 7From: Nature Reviews Molecular Cell Biology. (Vol. 6, Issue 6) Peer-ReviewedAuthor(s): David Stevens *http://www.ebi.ac.uk/biomodels A step towards the greater use of computational models in biology was taken when the world's first database of annotated biological models went online on 11...
- 8From: Nature Reviews Molecular Cell Biology. (Vol. 6, Issue 6) Peer-ReviewedThe dynamic properties of microtubules are regulated by plus-end tracking proteins (+TIPs), which associate with the distal ends of microtubules. Among the +TIPs are cytoplasmic linker proteins (CLIPs), which promote...
- 9From: Nature Reviews Molecular Cell Biology. (Vol. 6, Issue 6) Peer-ReviewedAuthor(s): Katrin Bussell Think of methyltransferases, and histone modification and epigenetic regulation probably spring to mind. Indeed, the Polycomb group protein Ezh2 does regulate histone H3 methylation on...
- 10From: Nature Reviews Molecular Cell Biology. (Vol. 6, Issue 6) Peer-ReviewedAuthor(s): Rachel Smallridge Microtubule-dependent molecular motors are responsible for the long-distance intracellular transport of organelles. Kinesins move organelles towards the plus end of microtubules -- that...
- 11From: Nature Reviews Molecular Cell Biology. (Vol. 6, Issue 6) Peer-ReviewedTwo become three Two domains are known to mediate protein-protein interactions by binding to phosphotyrosine (pTyr) residues in target proteins: Src-homology-2 (SH2) and pTyr-binding (PTB) domains. However, in Cell ,...
- 12From: Nature Reviews Molecular Cell Biology. (Vol. 6, Issue 6) Peer-ReviewedTo ensure its duplication, chromosomal DNA must be precisely duplicated in each cell cycle, with no sections left unreplicated, and no sections replicated more than once. Eukaryotic cells achieve this by dividing...
- 13From: Nature Reviews Molecular Cell Biology. (Vol. 6, Issue 6) Peer-ReviewedAuthor(s): Rachel Smallridge Since the first observations that kinases control endocytosis, a thorough understanding of their specific roles at distinct steps in endocytic pathways has been lacking. However,...
- 14From: Nature Reviews Molecular Cell Biology. (Vol. 6, Issue 6) Peer-ReviewedOn demand, rapid Ca[sup.2+]-triggered homotypic and exocytic membrane-fusion events are required to repair a torn plasma membrane, and we propose that this emergency-based fusion differs fundamentally from other rapid,...
- 15From: Nature Reviews Molecular Cell Biology. (Vol. 6, Issue 6) Peer-ReviewedEph receptor tyrosine kinases mould the behaviour of many cell types by binding membrane-anchored ligands, ephrins, at sites of cell-cell contact. Eph signals affect both of the contacting cells and can produce diverse...
- 16From: Nature Reviews Molecular Cell Biology. (Vol. 6, Issue 6) Peer-ReviewedCell cycle PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints . Lu, X., Nannenga, B. & Donehower, L. A. Genes Dev. 3 May 2005 (10.1101/gad.1291305) The ataxia-telangiectasia mutated (ATM)...
- 17From: Nature Reviews Molecular Cell Biology. (Vol. 6, Issue 6) Peer-ReviewedTo most of us, it would seem intuitively unlikely that the strategies adopted by cells to ensure survival are mechanistically linked to the processes involved in cell death. However, the study of autophagy has revealed...
- 18From: Nature Reviews Molecular Cell Biology. (Vol. 6, Issue 6) Peer-ReviewedAuthor(s): Amanda Tromans [1] It's not unusual for a protein to have different functions in different cellular contexts. But the discovery that an mRNA-export protein also helps to assemble the spindle during cell...