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- 1From: Nature Reviews Genetics. (Vol. 6, Issue 6) Peer-ReviewedAuthor(s): Sascha Sauer (corresponding author) [1]; Bodo M. H. Lange [1]; Johan Gobom [1]; Lajos Nyarsik [1]; Harald Seitz [1]; Hans Lehrach [1] The information encoded in the genome comprises genes, the protein...
- 2From: Nature Reviews Genetics. (Vol. 6, Issue 6) Peer-ReviewedAuthor(s): Jochen Graw (corresponding author) [1]; Hans-Hermann Brackmann [2]; Johannes Oldenburg [3]; Reinhard Schneppenheim [4]; Michael Spannagl [5]; Rainer Schwaab [2] Haemophilia A is the most severe inherited...
- 3From: Nature Reviews Genetics. (Vol. 6, Issue 6) Peer-ReviewedAuthor(s): Maureen A. O'Malley (corresponding author) [1]; Adam Bostanci [1]; Jane Calvert [1] News of genome patenting is often met with surprise, disbelief or dismissal. Nevertheless, several whole-genome patents...
- 4From: Nature Reviews Genetics. (Vol. 6, Issue 6) Peer-ReviewedAuthor(s): Mads Kaern (corresponding author) [1]; Timothy C. Elston [2]; William J. Blake [3]; James J. Collins [3] Stochasticity in gene expression arises from fluctuations in transcription and translation, despite...
- 5From: Nature Reviews Genetics. (Vol. 6, Issue 6) Peer-ReviewedAuthor(s): Mario R. Capecchi [1] Gene targeting -- creating designed genomic modifications -- has three enormous advantages relative to other procedures for introducing mutations into mice. First, the investigator...
- 6From: Nature Reviews Genetics. (Vol. 6, Issue 6) Peer-ReviewedAuthor(s): James Shorter (corresponding author) [1]; Susan Lindquist (corresponding author) [1] How a genotype and its environment interact to yield a phenotype poses a vast epistemological gap. Proteins that exhibit...
- 7From: Nature Reviews Genetics. (Vol. 6, Issue 6) Peer-ReviewedAuthor(s): Tanita Casci In 5 years time we could possess the most detailed genetic map so far of the history of human migrations. This is the ambitious plan of a privately financed US$4OM project, recently launched by...
- 8From: Nature Reviews Genetics. (Vol. 6, Issue 6) Peer-ReviewedAuthor(s): Ekat Kritikou The ultimate goal of genome-annotation programs is to correctly predict the sequence of every gene in a given organism. Caenorhabditis elegans has led the way, and Wei et al . now report an...
- 9From: Nature Reviews Genetics. (Vol. 6, Issue 6) Peer-ReviewedAgeing Analysis of long-lived C. elegans daf-2 mutants using serial analysis of gene expression . Halaschek-Wiener, J. et al . Genome Res. 18 April 2005 (10.1101/gr.3274805) This is the first study to use...
- 10From: Nature Reviews Genetics. (Vol. 6, Issue 6) Peer-ReviewedProper chromosome segregation is crucial for preventing fertility problems, birth defects and cancer. During mitotic cell divisions, sister chromatids separate from each other to opposite poles, resulting in two...
- 11From: Nature Reviews Genetics. (Vol. 6, Issue 6) Peer-ReviewedAuthor(s): Magdalena Skipper New work from Holstege and colleagues reveals that 'resting phase' is something of a misnomer. Their results in Saccharomyces cerevisiae show that many genes are actively transcribed...
- 12From: Nature Reviews Genetics. (Vol. 6, Issue 6) Peer-ReviewedAuthor(s): David Stevens *http://www.ebi.ac.uk/biomodels A step towards the greater use of computational models in biology was taken when the world's first database of annotated biological models went online on 11...
- 13From: Nature Reviews Genetics. (Vol. 6, Issue 6) Peer-ReviewedAuthor(s): Joanna Owens [1] Disparities between microarray data from different groups working on similar samples has made many question the validity of this widely adopted technology. Although the 'minimal...
- 14From: Nature Reviews Genetics. (Vol. 6, Issue 6) Peer-ReviewedCircadian Genetics Association of the length polymorphism in the human Per3 gene with the delayed sleep-phase syndrome: does latitude have an influence on it? . Pereira, D. S. et al . Sleep 28, 29-32 (2005)...
- 15From: Nature Reviews Genetics. (Vol. 6, Issue 6) Peer-ReviewedAuthor(s): Sheilagh Molloy [1] A recent study published in Science has established an exciting new direction in environmental genomics -- comparative metagenomic analysis.[illus. 1] For many years, environmental...
- 16From: Nature Reviews Genetics. (Vol. 6, Issue 6) Peer-ReviewedAlthough we are now well into the 'omics' era, the analysis and use of genomic and proteomic information continues to throw new challenges at us -- both scientific and otherwise. One example of this is highlighted in...
- 17From: Nature Reviews Genetics. (Vol. 6, Issue 6) Peer-ReviewedAuthor(s): Ekat Kritikou Gene expression is regulated at many levels, including the DNA-sequence, chromatin and nuclear levels. Perhaps the area about which least is known is how nuclear organization influences gene...
- 18From: Nature Reviews Genetics. (Vol. 6, Issue 6) Peer-ReviewedAuthor(s): David Stevens The amoeboid protozoan Dictyostelium discoideum is a strange beast, not just for its ability to transform from a unicellular to a multicellular state, but because, for a simple model...
- 19From: Nature Reviews Genetics. (Vol. 6, Issue 6) Peer-ReviewedAuthor(s): Mario Capecchi [illus. 1] Originally you trained in chemistry and physics. Why the transition to biology, especially at a time when many exciting discoveries were made in physics? I enjoyed physics a...
- 20From: Nature Reviews Genetics. (Vol. 6, Issue 6) Peer-ReviewedAuthor(s): Louisa Flintoft RNA silencing has been billed as a second form of immune system, allowing the cell to destroy viruses by recognizing their nucleic acids. But although this role is well-established in...