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- Search Terms:ISSN: 15537366AndISSN: 15537374AndVolume Number: 6AndIssue Number: 5AndStart Page: e1000898AndDate: 2010 Revise Search
- 1From: PLoS Pathogens. (Vol. 6, Issue 5) Peer-ReviewedMany immune correlates of [CD8.sup.+] T-cell-mediated control of HIV replication, including polyfunctionality, proliferative ability, and inhibitory receptor expression, have been discovered. However, no functional...
- 2From: PLoS Pathogens. (Vol. 6, Issue 5) Peer-ReviewedThe Esx-1 (type VII) secretion system is a major virulence determinant of pathogenic mycobacteria, including Mycobacterium marinum. However, the molecular events and host-pathogen interactions underlying Esx-1-mediated...
- 3From: PLoS Pathogens. (Vol. 6, Issue 5) Peer-ReviewedThe host vasculature is believed to constitute the principal route of dissemination of Neisseria meningitidis (Nm) throughout the body, resulting in septicaemia and meningitis in susceptible humans. In vitro, the Nm...
- 4From: PLoS Pathogens. (Vol. 6, Issue 5) Peer-ReviewedMutant forms of the Plasmodium falciparum transporter PfCRT constitute the key determinant of parasite resistance to chloroquine (CQ), the former first-line antimalarial, and are ubiquitous to infections that fail CQ...
- 5From: PLoS Pathogens. (Vol. 6, Issue 5) Peer-ReviewedChlamydia pneumoniae is a common human and animal pathogen associated with a wide range of diseases. Since the first isolation of C. pneumoniae TWAR in 1965, all human isolates have been essentially clonal, providing...
- 6From: PLoS Pathogens. (Vol. 6, Issue 5) Peer-ReviewedNK and [gamma][delta] T cells can eliminate tumor cells in many experimental models, but their effect on the development of tumors caused by virus infections in vivo is not known. Polyomavirus (PyV) induces tumors in...
- 7From: PLoS Pathogens. (Vol. 6, Issue 5) Peer-ReviewedThe inability of sodium antimony gluconate (SAG)-unresponsive kala-azar patients to clear Leishmania donovani (LD) infection despite SAG therapy is partly due to an ill-defined immune-dysfunction. Since dendritic cells...
- 8From: PLoS Pathogens. (Vol. 6, Issue 5) Peer-ReviewedIn RNA silencing, small RNAs produced by the RNase-III Dicer guide Argonaute-like proteins as part of RNA-induced silencing complexes (RISC) to regulate gene expression transcriptionally or post-transcriptionally. Here,...
- 9From: PLoS Pathogens. (Vol. 6, Issue 5) Peer-Reviewed
Crystal structure of HIV-1 gp41 including both fusion peptide and membrane proximal external regions
The HIV-1 envelope glycoprotein (Env) composed of the receptor binding domain gp120 and the fusion protein subunit gp41 catalyzes virus entry and is a major target for therapeutic intervention and for neutralizing... - 10From: PLoS Pathogens. (Vol. 6, Issue 5) Peer-ReviewedMany bacterial pathogens utilize a type III secretion system to deliver multiple effector proteins into host cells. Here we found that the type III effectors, NleE from enteropathogenic E. coli (EPEC) and OspZ from...
- 11From: PLoS Pathogens. (Vol. 6, Issue 5) Peer-ReviewedMucositis, also referred to as mucosal barrier injury, is one of the most debilitating side effects of radiotherapy and chemotherapy treatment. Clinically, mucositis is associated with pain, bacteremia, and...
- 12From: PLoS Pathogens. (Vol. 6, Issue 5) Peer-ReviewedMost RNA viruses lack the mechanisms to recognize and correct mutations that arise during genome replication, resulting in quasispecies diversity that is required for pathogenesis and adaptation. However, it is not...
- 13From: PLoS Pathogens. (Vol. 6, Issue 5) Peer-ReviewedThe global migration patterns of influenza viruses have profound implications for the evolutionary and epidemiological dynamics of the disease. We developed a novel approach to reconstruct the genetic history of human...
- 14From: PLoS Pathogens. (Vol. 6, Issue 5) Peer-ReviewedElucidating virus-host interactions responsible for HIV-1 transmission is important for advancing HIV-1 prevention strategies. To this end, single genome amplification (SGA) and sequencing of HIV-1 within the context of...
- 15From: PLoS Pathogens. (Vol. 6, Issue 5) Peer-ReviewedAmyloidosis describes a group of protein folding diseases in which amyloid proteins are abnormally deposited in organs and/or tissues as fine fibrils. Mouse senile amyloidosis is a disorder in which apolipoprotein A-II...
- 16From: PLoS Pathogens. (Vol. 6, Issue 5) Peer-ReviewedWhat Is the Evidence Linking Changes in the Microbiota to the Development of Allergic Disease? Two lines of evidence suggest that environmental changes are a major factor in the development of allergies: the increase...
- 17From: PLoS Pathogens. (Vol. 6, Issue 5) Peer-ReviewedWe have characterized a novel pleiotropic role for CymR, the master regulator of cysteine metabolism. We show here that CymR plays an important role both in stress response and virulence of Staphylococcus aureus. Genes...
- 18From: PLoS Pathogens. (Vol. 6, Issue 5) Peer-ReviewedHIV-1 Consistently Evades the Humoral Immune Response More than 25 years have passed since the discovery of HIV type 1, the causative agent of AIDS, and the first vaccine candidate to exhibit evidence for protection...
- 19From: PLoS Pathogens. (Vol. 6, Issue 5) Peer-ReviewedProtection against virulent pathogens that cause acute, fatal disease is often hampered by development of microbial resistance to traditional chemotherapeutics. Further, most successful pathogens possess an array of...
- 20From: PLoS Pathogens. (Vol. 6, Issue 5) Peer-ReviewedListeria monocytogenes (Lm) uses InlA to invade the tips of the intestinal villi, a location at which cell extrusion generates a transient defect in epithelial polarity that exposes the receptor for InlA, E-cadherin, on...