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- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 6AndIssue Number: 4AndStart Page: e1000916AndDate: 2010 Revise Search
- 1From: PLoS Genetics. (Vol. 6, Issue 4) Peer-ReviewedFragile X syndrome (FXS), the most common form of inherited mental retardation, is caused by the loss of functional fragile X mental retardation protein (FMRP). FMRP is an RNA-binding protein that can regulate the...
- 2From: PLoS Genetics. (Vol. 6, Issue 4) Peer-ReviewedGene duplication is a major mechanism facilitating adaptation to changing environments. From recent genomic analyses, the acquisition of zinc hypertolerance and hyperaccumulation characters discriminating Arabidopsis...
- 3From: PLoS Genetics. (Vol. 6, Issue 4) Peer-ReviewedIt was recently shown that a large portion of the human transcriptome can originate from within repetitive elements, leading to ectopic expression of protein-coding genes. However the mechanism of transcriptional...
- 4From: PLoS Genetics. (Vol. 6, Issue 4) Peer-ReviewedHair is important for thermoregulation, physical protection, sensory activity, seasonal camouflage, and social interactions. Hair is generated in hair follicles (HFs) and, following morphogenesis, HFs undergo cyclic...
- 5From: PLoS Genetics. (Vol. 6, Issue 4) Peer-ReviewedThe recent success of genome-wide association studies (GWAS) is now followed by the challenge to determine how the reported susceptibility variants mediate complex traits and diseases. Expression quantitative trait loci...
- 6From: PLoS Genetics. (Vol. 6, Issue 4) Peer-ReviewedRetinal vascular caliber provides information about the structure and health of the microvascular system and is associated with cardiovascular and cerebrovascular diseases. Compared to European Americans, African...
- 7From: PLoS Genetics. (Vol. 6, Issue 4) Peer-ReviewedModel organisms have played an important role in the elucidation of multiple genes and cellular processes that regulate aging. In this study we utilized the budding yeast, Saccharomyces cerevisiae, in a large-scale...
- 8From: PLoS Genetics. (Vol. 6, Issue 4) Peer-ReviewedActin-related proteins are ubiquitous components of chromatin remodelers and are conserved from yeast to man. We have examined the role of the budding yeast actin-related protein Arp6 in gene expression, both as a...
- 9From: PLoS Genetics. (Vol. 6, Issue 4) Peer-ReviewedAll skeletal muscle progenitor cells in the body derive from the dermomyotome, the dorsal epithelial domain of developing somites. These multipotent stem cells express Pax3, and this expression is maintained in the...
- 10From: PLoS Genetics. (Vol. 6, Issue 4) Peer-ReviewedDNA synthesis must be performed with extreme precision to maintain genomic integrity. In mammalian cells, different genomic regions are replicated at defined times, perhaps to preserve epigenetic information and cell...
- 11From: PLoS Genetics. (Vol. 6, Issue 4) Peer-ReviewedThe spatial organization of the genome in the nucleus plays a role in the regulation of gene expression. Whether coregulated genes are subject to coordinated repositioning to a shared nuclear space is a matter of...
- 12From: PLoS Genetics. (Vol. 6, Issue 4) Peer-ReviewedAlthough genome-wide association studies (GWAS) of complex traits have yielded more reproducible associations than had been discovered using any other approach, the loci characterized to date do not account for much of...
- 13From: PLoS Genetics. (Vol. 6, Issue 4) Peer-ReviewedTelomeric repeats preserve genome integrity by stabilizing chromosomes, a function that appears to be important for both cancer and aging. In view of this critical role in genomic integrity, the telomere's own integrity...
- 14From: PLoS Genetics. (Vol. 6, Issue 4) Peer-ReviewedOne of the striking findings of comparative developmental genetics was that expression patterns of core transcription factors are extraordinarily conserved in bilaterians. However, it remains unclear whether...
- 15From: PLoS Genetics. (Vol. 6, Issue 4) Peer-ReviewedLipoprotein-associated phospholipase A2 (Lp-[PLA.sub.2]) is an emerging risk factor and therapeutic target for cardiovascular disease. The activity and mass of this enzyme are heritable traits, but major genetic...
- 16From: PLoS Genetics. (Vol. 6, Issue 4) Peer-ReviewedLRRK2 plays an important role in Parkinson's disease (PD), but its biological functions are largely unknown. Here, we cloned the homolog of human LRRK2, characterized its expression, and investigated its biological...
- 17From: PLoS Genetics. (Vol. 6, Issue 4) Peer-ReviewedThe mechanisms governing telomere replication in humans are still poorly understood. To fill this gap, we investigated the timing of replication of single telomeres in human cells. Using in situ hybridization...
- 18From: PLoS Genetics. (Vol. 6, Issue 4) Peer-ReviewedUsing forward genetics, we have identified the genes mutated in two classes of zebrafish fin mutants. The mutants of the first class are characterized by defects in embryonic fin morphogenesis, which are due to...
- 19From: PLoS Genetics. (Vol. 6, Issue 4) Peer-ReviewedPlant resistance (R) proteins provide a robust surveillance system to defend against potential pathogens. Despite their importance in plant innate immunity, relatively few of the ~170 R proteins in Arabidopsis have...
- 20From: PLoS Genetics. (Vol. 6, Issue 4) Peer-ReviewedCDH11 gene copy number and expression are frequently lost in human retinoblastomas and in retinoblastomas arising in TAg-RB mice. To determine the effect of Cdh11 loss in tumorigenesis, we crossed Cdh11 null mice with...