Showing Results for
- Academic Journals (52)
Search Results
- 52
Academic Journals
- 52
- Search Terms:ISSN: 15537366AndISSN: 15537374AndVolume Number: 6AndIssue Number: 4AndStart Page: e1000758AndDate: 2010 Revise Search
- 1From: PLoS Pathogens. (Vol. 6, Issue 4) Peer-ReviewedPrevious studies have demonstrated the involvement of complement (C) in induction of efficient CTL responses against different viral infections, but the exact role of complement in this process has not been determined....
- 2From: PLoS Pathogens. (Vol. 6, Issue 4) Peer-Reviewed
Topology and organization of the Salmonella typhimurium type III Secretion Needle complex components
The correct organization of single subunits of multi-protein machines in a three dimensional context is critical for their functionality. Type III secretion systems (T3SS) are molecular machines with the capacity to... - 3From: PLoS Pathogens. (Vol. 6, Issue 4) Peer-ReviewedHost cell attachment by Toxoplasma gondii is dependent on polarized secretion of apical adhesins released from the micronemes. Subsequent translocation of these adhesive complexes by an actin-myosin motor powers...
- 4From: PLoS Pathogens. (Vol. 6, Issue 4) Peer-ReviewedCertain environmental microorganisms can cause severe human infections, even in the absence of an obvious requirement for transition through an animal host for replication ("accidental virulence"). To understand this...
- 5From: PLoS Pathogens. (Vol. 6, Issue 4) Peer-ReviewedThe mechanism of membrane fusion by "class II" viral fusion proteins follows a pathway that involves large-scale domain rearrangements of the envelope glycoprotein (E) and a transition from dimers to trimers. The...
- 6From: PLoS Pathogens. (Vol. 6, Issue 4) Peer-ReviewedWe have previously reported that the NS3 helicase (N3H) and NS5B-to-3'X (N5BX) regions are important for the efficient replication of hepatitis C virus (HCV) strain JFH-1 and viral production in HuH-7 cells. In the...
- 7From: PLoS Pathogens. (Vol. 6, Issue 4) Peer-ReviewedThe capacity of infected cells to undergo apoptosis upon insult with a pathogen is an ancient innate immune defense mechanism. Consequently, the ability of persisting, intracellular pathogens such as the human pathogen...
- 8From: PLoS Pathogens. (Vol. 6, Issue 4) Peer-ReviewedThe emergence of fungal infections as major causes of morbidity and mortality in immunosuppressed individuals has prompted studies into how the host recognizes fungal pathogens. Fungi are eukaryotes and as such share...
- 9From: PLoS Pathogens. (Vol. 6, Issue 4) Peer-ReviewedAsymmetrical dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), is a predictor of mortality in critical illness. Severe malaria (SM) is associated with decreased NO bioavailability, but the...
- 10From: PLoS Pathogens. (Vol. 6, Issue 4) Peer-ReviewedCells of the myeloid lineage are significant targets for human immunodeficiency virus (HIV) in humans and simian immunodeficiency virus (SIV) in monkeys. Monocytes play critical roles in innate and adaptive immunity...
- 11From: PLoS Pathogens. (Vol. 6, Issue 4) Peer-ReviewedDue to the lack of fossil evidence, the timescales of bacterial evolution are largely unknown. The speed with which genetic change accumulates in populations of pathogenic bacteria, however, is a key parameter that is...
- 12From: PLoS Pathogens. (Vol. 6, Issue 4) Peer-ReviewedArgentine hemorrhagic fever (AHF) is an endemo-epidemic disease caused by Junin virus (JUNV), a member of the arenaviridae family. Although a recently introduced live attenuated vaccine has proven to be effective, AHF...
- 13From: PLoS Pathogens. (Vol. 6, Issue 4) Peer-ReviewedGenetic strategies that reduce or block pathogen transmission by mosquitoes have been proposed as a means of augmenting current control measures to reduce the growing burden of vector-borne diseases. The endosymbiotic...
- 14From: PLoS Pathogens. (Vol. 6, Issue 4) Peer-ReviewedStreptococcus agalactiae is a major neonatal pathogen whose infectious route involves septicemia. This pathogen does not synthesize heme, but scavenges it from blood to activate a respiration metabolism, which increases...
- 15From: PLoS Pathogens. (Vol. 6, Issue 4) Peer-ReviewedAn elevated growth temperature often inhibits plant defense responses and renders plants more susceptible to pathogens. However, the molecular mechanisms underlying this modulation are unknown. To genetically dissect...
- 16From: PLoS Pathogens. (Vol. 6, Issue 4) Peer-ReviewedThe murine model of T. cruzi infection has provided compelling evidence that development of host resistance against intracellular protozoans critically depends on the activation of members of the Toll-like receptor...
- 17From: PLoS Pathogens. (Vol. 6, Issue 4) Peer-ReviewedThe coagulation system is characterized by the sequential and highly localized activation of a series of serine proteases, culminating in the conversion of fibrinogen into fibrin, and formation of a fibrin clot. Here we...
- 18From: PLoS Pathogens. (Vol. 6, Issue 4) Peer-ReviewedAntibody protection against flaviviruses is associated with the development of neutralizing antibodies against the viral envelope (E) protein. Prior studies with West Nile virus (WNV) identified therapeutic mouse and...
- 19From: PLoS Pathogens. (Vol. 6, Issue 4) Peer-ReviewedDisruption of the blood-brain barrier (BBB) is a hallmark event in the pathophysiology of bacterial meningitis. Several inflammatory mediators, such as tumor necrosis factor alpha (TNF-[alpha]), nitric oxide and matrix...
- 20From: PLoS Pathogens. (Vol. 6, Issue 4) Peer-ReviewedDespite the described central role of jasmonate signaling in plant defense against necrotrophic pathogens, the existence of intraspecific variation in pathogen capacity to activate or evade plant jasmonate-mediated...