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- Search Terms:ISSN: 1553734XAndISSN: 15537358AndVolume Number: 6AndIssue Number: 4AndStart Page: e1000729AndDate: 2010 Revise Search
- 1From: PLoS Computational Biology. (Vol. 6, Issue 4) Peer-ReviewedThe human brain efficiently solves certain operations such as object recognition and categorization through a massively parallel network of dedicated processors. However, human cognition also relies on the ability to...
- 2From: PLoS Computational Biology. (Vol. 6, Issue 4) Peer-ReviewedAlthough models based on independent component analysis (ICA) have been successful in explaining various properties of sensory coding in the cortex, it remains unclear how networks of spiking neurons using realistic...
- 3From: PLoS Computational Biology. (Vol. 6, Issue 4) Peer-ReviewedHuman Immunodeficiency Virus 1 uses for entry into host cells a receptor (CD4) and one of two co-receptors (CCR5 or CXCR4). Recently, a new class of antiretroviral drugs has entered clinical practice that specifically...
- 4From: PLoS Computational Biology. (Vol. 6, Issue 4) Peer-ReviewedTime-delays are common in many physical and biological systems and they give rise to complex dynamic phenomena. The elementary processes involved in template biopolymerization, such as mRNA and protein synthesis,...
- 5From: PLoS Computational Biology. (Vol. 6, Issue 4) Peer-ReviewedA primary goal for artificial nose (eNose) technology is to report perceptual qualities of novel odors. Currently, however, eNoses primarily detect and discriminate between odorants they previously "learned". We tuned...
- 6From: PLoS Computational Biology. (Vol. 6, Issue 4) Peer-ReviewedThe threshold firing frequency of a neuron is a characterizing feature of its dynamical behaviour, in turn determining its role in the oscillatory activity of the brain. Two main types of dynamics have been identified...
- 7From: PLoS Computational Biology. (Vol. 6, Issue 4) Peer-ReviewedABC transporters are a large family of membrane proteins involved in a variety of cellular processes, including multidrug and tumor resistance and ion channel regulation. Advances in the structural and functional...
- 8From: PLoS Computational Biology. (Vol. 6, Issue 4) Peer-ReviewedCerebellar Purkinje cells display complex intrinsic dynamics. They fire spontaneously, exhibit bistability, and via mutual network interactions are involved in the generation of high frequency oscillations and...
- 9From: PLoS Computational Biology. (Vol. 6, Issue 4) Peer-ReviewedProtein knots, mostly regarded as intriguing oddities, are gradually being recognized as significant structural motifs. Seven distinctly knotted folds have already been identified. It is by and large unclear how these...
- 10From: PLoS Computational Biology. (Vol. 6, Issue 4) Peer-ReviewedIn the mammalian hippocampus, the dentate gyrus (DG) is characterized by sparse and powerful unidirectional projections to CA3 pyramidal cells, the so-called mossy fibers. Mossy fiber synapses appear to duplicate, in...
- 11From: PLoS Computational Biology. (Vol. 6, Issue 4) Peer-ReviewedVariants resistant to compounds specifically targeting HCV are observed in clinical trials. A multi-variant viral dynamic model was developed to quantify the evolution and in vivo fitness of variants in subjects dosed...
- 12From: PLoS Computational Biology. (Vol. 6, Issue 4) Peer-ReviewedThe liver plays a key role in removing harmful chemicals from the body and is therefore often the first tissue to suffer potentially adverse consequences. To protect public health it is necessary to quantitatively...
- 13From: PLoS Computational Biology. (Vol. 6, Issue 4) Peer-ReviewedMany genome-wide datasets are routinely generated to study different aspects of biological systems, but integrating them to obtain a coherent view of the underlying biology remains a challenge. We propose simultaneous...
- 14From: PLoS Computational Biology. (Vol. 6, Issue 4) Peer-ReviewedFeedback modules, which appear ubiquitously in biological regulations, are often subject to disturbances from the input, leading to fluctuations in the output. Thus, the question becomes how a feedback system can...
- 15From: PLoS Computational Biology. (Vol. 6, Issue 4) Peer-ReviewedThe majority of expression quantitative trait locus (eQTL) studies have been carried out in single tissues or cell types, using methods that ignore information shared across tissues. Although global analysis of RNA...
- 16From: PLoS Computational Biology. (Vol. 6, Issue 4) Peer-ReviewedFolds are the basic building blocks of protein structures. Understanding the emergence of novel protein folds is an important step towards understanding the rules governing the evolution of protein structure and...
- 17From: PLoS Computational Biology. (Vol. 6, Issue 4) Peer-ReviewedNervous systems are information processing networks that evolved by natural selection, whereas very large scale integrated (VLSI) computer circuits have evolved by commercially driven technology development. Here we...
- 18From: PLoS Computational Biology. (Vol. 6, Issue 4) Peer-ReviewedEscherichia coli chemotactic motion in spatiotemporally varying environments is studied by using a computational model based on a coarse-grained description of the intracellular signaling pathway dynamics. We find that...
- 19From: PLoS Computational Biology. (Vol. 6, Issue 4) Peer-ReviewedType 2 diabetes mellitus (T2DM) is a disorder characterized by both insulin resistance and impaired insulin secretion. Recent transcriptomics studies related to T2DM have revealed changes in expression of a large number...
- 20From: PLoS Computational Biology. (Vol. 6, Issue 4) Peer-ReviewedCopy number variants (CNVs) have recently been recognized as a common form of genomic variation in humans. Hundreds of CNVs can be detected in any individual genome using genomic microarrays or whole genome sequencing...