Showing Results for
- Academic Journals (26)
Search Results
- 26
Academic Journals
- 26
- Search Terms:ISSN: 15537390AndISSN: 15537404AndVolume Number: 6AndIssue Number: 3AndStart Page: e1000883AndDate: 2010 Revise Search
- 1From: PLoS Genetics. (Vol. 6, Issue 3) Peer-ReviewedAlternative splicing controls the expression of many genes, including the Drosophila sex determination gene Sex-lethal (Sxl). Sxl expression is controlled via a negative regulatory mechanism where inclusion of the...
- 2From: PLoS Genetics. (Vol. 6, Issue 3) Peer-ReviewedSequence data from the past decade has laid bare the significance of horizontal gene transfer in creating genetic diversity in the bacterial world. Regulatory evolution, in which non-coding DNA is mutated to create new...
- 3From: PLoS Genetics. (Vol. 6, Issue 3) Peer-ReviewedWe report for the first time the genomics of a nuclear compartment of the eukaryotic cell. 454 sequencing and microarray analysis revealed the pattern of nucleolus-associated chromatin domains (NADs) in the linear human...
- 4From: PLoS Genetics. (Vol. 6, Issue 3) Peer-ReviewedBardet-Biedl Syndrome (BBS) is a heterogeneous syndromic form of retinal degeneration. We have identified a novel transcript of a known BBS gene, BBS3 (ARL6), which includes an additional exon. This transcript, BBS3L,...
- 5From: PLoS Genetics. (Vol. 6, Issue 3) Peer-ReviewedPapillorenal syndrome (PRS, also known as renal-coloboma syndrome) is an autosomal dominant disease characterized by potentially-blinding congenital optic nerve excavation and congenital kidney abnormalities. Many...
- 6From: PLoS Genetics. (Vol. 6, Issue 3) Peer-ReviewedThymineless death (TLD) is a classic and enigmatic phenomenon, documented in bacterial, yeast, and human cells, whereby cells lose viability rapidly when deprived of thymine. Despite its being the essential mode of...
- 7From: PLoS Genetics. (Vol. 6, Issue 3) Peer-ReviewedCoordinated cell migration during development is crucial for morphogenesis and largely relies on cells of the neural crest lineage that migrate over long distances to give rise to organs and tissues throughout the body....
- 8From: PLoS Genetics. (Vol. 6, Issue 3) Peer-ReviewedHighly repetitive and transposable element rich regions of the genome must be stabilized by the presence of heterochromatin. A direct role for RNA interference in the establishment of heterochromatin has been...
- 9From: PLoS Genetics. (Vol. 6, Issue 3) Peer-ReviewedThe last decade has witnessed important advances in our understanding of the genetics of pigmentation in European populations, but very little is known about the genes involved in skin pigmentation variation in East...
- 10From: PLoS Genetics. (Vol. 6, Issue 3) Peer-ReviewedIn mammals and in plants, parental genome dosage imbalance deregulates embryo growth and might be involved in reproductive isolation between emerging new species. Increased dosage of maternal genomes represses growth...
- 11From: PLoS Genetics. (Vol. 6, Issue 3) Peer-ReviewedHAP2(GCS1) is a deeply conserved sperm protein that is essential for gamete fusion. Here we use complementation assays to define major functional regions of the Arabidopsis thaliana ortholog using HAP2(GCS1) variants...
- 12From: PLoS Genetics. (Vol. 6, Issue 3) Peer-ReviewedKruppel-associated box domain-zinc finger proteins (KRAB-ZFPs) are tetrapod-specific transcriptional repressors encoded in the hundreds by the human genome. In order to explore their as yet ill-defined impact on gene...
- 13From: PLoS Genetics. (Vol. 6, Issue 3) Peer-ReviewedWe investigated eight families with a novel subtype of congenital generalized lipodystrophy (CGL4) of whom five members had died from sudden cardiac death during their teenage years. ECG studies revealed features of...
- 14From: PLoS Genetics. (Vol. 6, Issue 3) Peer-ReviewedTDP-43 proteinopathies have been observed in a wide range of neurodegenerative diseases. Mutations in the gene encoding TDP-43 (i.e., TDP) have been identified in amyotrophic lateral sclerosis (ALS) and in...
- 15From: PLoS Genetics. (Vol. 6, Issue 3) Peer-ReviewedThere is growing evidence that gene expression profiling of peripheral blood cells is a valuable tool for assessing gene signatures related to exposure, drug-response, or disease. However, the true promise of this...
- 16From: PLoS Genetics. (Vol. 6, Issue 3) Peer-ReviewedAllele frequency differences across populations can provide valuable information both for studying population structure and for identifying loci that have been targets of natural selection. Here, we examine the...
- 17From: PLoS Genetics. (Vol. 6, Issue 3) Peer-ReviewedXeroderma pigmentosum (XP) is caused by defects in the nucleotide excision repair (NER) pathway. NER removes helix-distorting DNA lesions, such as UV-induced photodimers, from the genome. Patients suffering from XP...
- 18From: PLoS Genetics. (Vol. 6, Issue 3) Peer-ReviewedAs Arabidopsis thaliana is increasingly employed in evolutionary and ecological studies, it is essential to understand patterns of natural genetic variation and the forces that shape them. Previous work focusing mostly...
- 19From: PLoS Genetics. (Vol. 6, Issue 3) Peer-ReviewedThe trimeric CAK complex functions in cell cycle control by phosphorylating and activating Cdks while TFIIH-linked CAK functions in transcription. CAK also associates into a tetramer with Xpd, and our analysis of young...
- 20From: PLoS Genetics. (Vol. 6, Issue 3) Peer-ReviewedTransposable elements represent a large proportion of the eukaryotic genomes. Long Terminal Repeat (LTR) retrotransposons are very abundant and constitute the predominant family of transposable elements in plants....