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- Search Terms:ISSN: 15537366AndISSN: 15537374AndVolume Number: 6AndIssue Number: 3AndStart Page: e1000812AndDate: 2010 Revise Search
- 1From: PLoS Pathogens. (Vol. 6, Issue 3) Peer-ReviewedPseudomonas aeruginosa causes severe sight-threatening corneal infections, with the inflammatory response to the pathogen being the major factor resulting in damage to the cornea that leads to loss of visual acuity. We...
- 2From: PLoS Pathogens. (Vol. 6, Issue 3) Peer-ReviewedNatural killer (NK) cells play an essential role in innate immune control of poxviral infections in vivo. However, the mechanism(s) underlying NK cell activation and function in response to poxviruses remains poorly...
- 3From: PLoS Pathogens. (Vol. 6, Issue 3) Peer-ReviewedNucleophosmin (NPM) is a multifunctional nuclear phosphoprotein and a histone chaperone implicated in chromatin organization and transcription control. Oncogenic Kaposi's sarcoma herpesvirus (KSHV) is the etiological...
- 4From: PLoS Pathogens. (Vol. 6, Issue 3) Peer-ReviewedKupffer cells (KCs) represent the major phagocytic population within the liver and provide an intracellular niche for the survival of a number of important human pathogens. Although KCs have been extensively studied in...
- 5From: PLoS Pathogens. (Vol. 6, Issue 3) Peer-ReviewedExosomes are secreted cellular vesicles that can induce specific [CD4.sup.+] T cell responses in vivo when they interact with competent antigen-presenting cells like mature dendritic cells (mDCs). The Trojan exosome...
- 6From: PLoS Pathogens. (Vol. 6, Issue 3) Peer-ReviewedExtracellular RNA is becoming increasingly recognized as a signaling molecule. Virally derived double stranded (ds)RNA released into the extracellular space during virus induced cell lysis acts as a powerful inducer of...
- 7From: PLoS Pathogens. (Vol. 6, Issue 3) Peer-ReviewedModulation of host DNA synthesis is essential for many viruses to establish productive infections and contributes to viral diseases. Human cytomegalovirus (HCMV), a large DNA virus, blocks host DNA synthesis and...
- 8From: PLoS Pathogens. (Vol. 6, Issue 3) Peer-ReviewedPrion diseases are fatal neurodegenerative diseases of humans and animals characterized by gray matter spongiosis and accumulation of aggregated, misfolded, protease-resistant prion protein (PrPres). PrPres can be...
- 9From: PLoS Pathogens. (Vol. 6, Issue 3) Peer-ReviewedLegionella pneumophila is an intracellular pathogen responsible for Legionnaires' disease. This bacterium uses the Dot/Icm type IV secretion system to inject a large number of bacterial proteins into host cells to...
- 10From: PLoS Pathogens. (Vol. 6, Issue 3) Peer-ReviewedCandida albicans in the immunocompetent host is a benign member of the human microbiota. Though, when host physiology is disrupted, this commensal-host interaction can degenerate and lead to an opportunistic infection....
- 11From: PLoS Pathogens. (Vol. 6, Issue 3) Peer-ReviewedSeveral essential biochemical processes are situated in mitochondria. The metabolic transformation of mitochondria in distinct lineages of eukaryotes created proteomes ranging from thousands of proteins to what appear...
- 12From: PLoS Pathogens. (Vol. 6, Issue 3) Peer-ReviewedViruses use cellular machinery to enter and infect cells. In this study we address the cell entry mechanisms of non- enveloped adenoviruses (Ads). We show that protein VI, an internal capsid protein, is rapidly exposed...
- 13From: PLoS Pathogens. (Vol. 6, Issue 3) Peer-ReviewedLassa virus (LASV), the causative agent of Lassa fever (LF), is endemic in West Africa, accounting for substantial morbidity and mortality. In spite of ongoing research efforts, LF pathogenesis and mechanisms of LASV...
- 14From: PLoS Pathogens. (Vol. 6, Issue 3) Peer-ReviewedThe anthrax toxin is a tripartite toxin, where the two enzymatic subunits require the third subunit, the protective antigen (PA), to interact with cells and be escorted to their cytoplasmic targets. PA binds to cells...
- 15From: PLoS Pathogens. (Vol. 6, Issue 3) Peer-ReviewedThe cell envelope of mycobacteria, a group of Gram positive bacteria, is composed of a plasma membrane and a Gram-negative-like outer membrane containing mycolic acids. In addition, the surface of the mycobacteria is...
- 16From: PLoS Pathogens. (Vol. 6, Issue 3) Peer-ReviewedProduction of the pro-inflammatory cytokine IL-12 by innate phagocytes drives the differentiation of IFN-[gamma]- producing effector T cells during Toxoplasma gondii infection. However, the role of IL-12 in the...
- 17From: PLoS Pathogens. (Vol. 6, Issue 3) Peer-ReviewedThe Thailand-Cambodia border is the epicenter for drug-resistant falciparum malaria. Previous studies have shown that chloroquine (CQ) and pyrimethamine resistance originated in this region and eventually spread to...
- 18From: PLoS Pathogens. (Vol. 6, Issue 3) Peer-ReviewedVirus infections can result in a range of cellular injuries and commonly this involves both the plasma and intracellular membranes, resulting in enhanced permeability. Viroporins are a group of proteins that interact...
- 19From: PLoS Pathogens. (Vol. 6, Issue 3) Peer-ReviewedDengue viruses (DENVs) are emerging, mosquito-borne flaviviruses which cause dengue fever and dengue hemorrhagic fever. The DENV complex consists of 4 serotypes designated DENV1-DENV4. Following natural infection with...
- 20From: PLoS Pathogens. (Vol. 6, Issue 3) Peer-ReviewedThe prevailing paradigm of T lymphocyte control of viral replication is that the protective capacity of virus-specific [CD8.sup.+] T cells is directly proportional to the number of functions they can perform, with IL-2...